molecular Swiss army knife: OmpA structure, function and expression
The OmpA outer membrane protein of Escherichia coli and other enterobacteria is a multifaceted protein. This protein is expressed to very high levels and ompA is tightly regulated at the posttranscriptional level. It can function as an adhesin and invasin, participate in biofilm formation, act as bo...
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| Veröffentlicht in: | FEMS microbiology letters 2007-08, Vol.273 (1), p.1-11 |
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| creator | Smith, Stephen G.J Mahon, Vivienne Lambert, Matthew A Fagan, Robert P |
| description | The OmpA outer membrane protein of Escherichia coli and other enterobacteria is a multifaceted protein. This protein is expressed to very high levels and ompA is tightly regulated at the posttranscriptional level. It can function as an adhesin and invasin, participate in biofilm formation, act as both an immune target and evasin, and serves as a receptor for several bacteriophages. Many of these properties are due to four short protein loops that emanate from the protein to the outside of the cell. Herein it is described how the structure of this protein relates to its many functions. |
| doi_str_mv | 10.1111/j.1574-6968.2007.00778.x |
| format | Article |
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This protein is expressed to very high levels and ompA is tightly regulated at the posttranscriptional level. It can function as an adhesin and invasin, participate in biofilm formation, act as both an immune target and evasin, and serves as a receptor for several bacteriophages. Many of these properties are due to four short protein loops that emanate from the protein to the outside of the cell. Herein it is described how the structure of this protein relates to its many functions.</description><identifier>ISSN: 0378-1097</identifier><identifier>EISSN: 1574-6968</identifier><identifier>DOI: 10.1111/j.1574-6968.2007.00778.x</identifier><identifier>PMID: 17559395</identifier><identifier>CODEN: FMLED7</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>adhesion ; Amino Acid Sequence ; Bacterial Outer Membrane Proteins - chemistry ; Bacterial Outer Membrane Proteins - genetics ; Bacterial Outer Membrane Proteins - immunology ; Bacterial Outer Membrane Proteins - physiology ; Bacteriology ; Biofilms ; Biological and medical sciences ; E coli ; Escherichia coli ; Escherichia coli - chemistry ; Escherichia coli - physiology ; Escherichia coli Proteins - chemistry ; Escherichia coli Proteins - genetics ; Escherichia coli Proteins - immunology ; Escherichia coli Proteins - physiology ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression Regulation, Bacterial ; Genetics ; immune evasion ; invasion ; Membrane proteins ; Microbiology ; Models, Molecular ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Molecular structure ; OmpA ; outer membrane protein ; Phages ; pore-forming protein ; Post-transcription ; Protein structure ; Proteins ; Structure-function relationships ; β-barrel</subject><ispartof>FEMS microbiology letters, 2007-08, Vol.273 (1), p.1-11</ispartof><rights>2007 Federation of European Microbiological Societies 2007</rights><rights>2007 INIST-CNRS</rights><rights>2007 Federation of European Microbiological Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6398-8b3b19d80430db42e72118b630ebfd19f79d774f3333c60608468557d9567e813</citedby><cites>FETCH-LOGICAL-c6398-8b3b19d80430db42e72118b630ebfd19f79d774f3333c60608468557d9567e813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1574-6968.2007.00778.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1574-6968.2007.00778.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18879635$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17559395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Stephen G.J</creatorcontrib><creatorcontrib>Mahon, Vivienne</creatorcontrib><creatorcontrib>Lambert, Matthew A</creatorcontrib><creatorcontrib>Fagan, Robert P</creatorcontrib><title>molecular Swiss army knife: OmpA structure, function and expression</title><title>FEMS microbiology letters</title><addtitle>FEMS Microbiol Lett</addtitle><description>The OmpA outer membrane protein of Escherichia coli and other enterobacteria is a multifaceted protein. This protein is expressed to very high levels and ompA is tightly regulated at the posttranscriptional level. It can function as an adhesin and invasin, participate in biofilm formation, act as both an immune target and evasin, and serves as a receptor for several bacteriophages. Many of these properties are due to four short protein loops that emanate from the protein to the outside of the cell. Herein it is described how the structure of this protein relates to its many functions.</description><subject>adhesion</subject><subject>Amino Acid Sequence</subject><subject>Bacterial Outer Membrane Proteins - chemistry</subject><subject>Bacterial Outer Membrane Proteins - genetics</subject><subject>Bacterial Outer Membrane Proteins - immunology</subject><subject>Bacterial Outer Membrane Proteins - physiology</subject><subject>Bacteriology</subject><subject>Biofilms</subject><subject>Biological and medical sciences</subject><subject>E coli</subject><subject>Escherichia coli</subject><subject>Escherichia coli - chemistry</subject><subject>Escherichia coli - physiology</subject><subject>Escherichia coli Proteins - chemistry</subject><subject>Escherichia coli Proteins - genetics</subject><subject>Escherichia coli Proteins - immunology</subject><subject>Escherichia coli Proteins - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Genetics</subject><subject>immune evasion</subject><subject>invasion</subject><subject>Membrane proteins</subject><subject>Microbiology</subject><subject>Models, Molecular</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Molecular structure</subject><subject>OmpA</subject><subject>outer membrane protein</subject><subject>Phages</subject><subject>pore-forming protein</subject><subject>Post-transcription</subject><subject>Protein structure</subject><subject>Proteins</subject><subject>Structure-function relationships</subject><subject>β-barrel</subject><issn>0378-1097</issn><issn>1574-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkV1rFDEUhoNY7Fr9CxoQvXLGk8nkq3hTFtsKK72ovQ6ZTCKzzpfJDt3992acxUJR9MAhCXnek5PzIoQJ5CTFh21OmCgzrrjMCwCRpxQy3z9Bq98XT9EKqJAZASVO0fMYtwBQFsCfoVMiGFNUsRVad0Pr7NSagG_vmxixCd0Bf-8b787xTTde4LgLk91Nwb3Hfurtrhl6bPoau_0YXIzp-AKdeNNG9_K4nqG7y09f19fZ5ubq8_pik1lOlcxkRSuiagklhboqCycKQmTFKbjK10R5oWohSk9TWA4cZMklY6JWjAsnCT1D75a6Yxh-TC7udNdE69rW9G6YohbAhWSS_xMkSgLlwBL45hG4HabQp0_oggJntGCkSJRcKBuGGIPzegxNZ8JBE9CzH3qr57Hreex69kP_8kPvk_TV8YGp6lz9IDwakIC3R8BEa1ofTG-b-MBJKRSnM_dx4e6b1h3-uwF9-WWTNklOF_kwjX8RZ3_q_vWi8mbQ5ltIjd3dFkBoAiRPSX8CrCy7Xw</recordid><startdate>200708</startdate><enddate>200708</enddate><creator>Smith, Stephen G.J</creator><creator>Mahon, Vivienne</creator><creator>Lambert, Matthew A</creator><creator>Fagan, Robert P</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>200708</creationdate><title>molecular Swiss army knife: OmpA structure, function and expression</title><author>Smith, Stephen G.J ; Mahon, Vivienne ; Lambert, Matthew A ; Fagan, Robert P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6398-8b3b19d80430db42e72118b630ebfd19f79d774f3333c60608468557d9567e813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>adhesion</topic><topic>Amino Acid Sequence</topic><topic>Bacterial Outer Membrane Proteins - chemistry</topic><topic>Bacterial Outer Membrane Proteins - genetics</topic><topic>Bacterial Outer Membrane Proteins - immunology</topic><topic>Bacterial Outer Membrane Proteins - physiology</topic><topic>Bacteriology</topic><topic>Biofilms</topic><topic>Biological and medical sciences</topic><topic>E coli</topic><topic>Escherichia coli</topic><topic>Escherichia coli - chemistry</topic><topic>Escherichia coli - physiology</topic><topic>Escherichia coli Proteins - chemistry</topic><topic>Escherichia coli Proteins - genetics</topic><topic>Escherichia coli Proteins - immunology</topic><topic>Escherichia coli Proteins - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Bacterial</topic><topic>Genetics</topic><topic>immune evasion</topic><topic>invasion</topic><topic>Membrane proteins</topic><topic>Microbiology</topic><topic>Models, Molecular</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Molecular structure</topic><topic>OmpA</topic><topic>outer membrane protein</topic><topic>Phages</topic><topic>pore-forming protein</topic><topic>Post-transcription</topic><topic>Protein structure</topic><topic>Proteins</topic><topic>Structure-function relationships</topic><topic>β-barrel</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Stephen G.J</creatorcontrib><creatorcontrib>Mahon, Vivienne</creatorcontrib><creatorcontrib>Lambert, Matthew A</creatorcontrib><creatorcontrib>Fagan, Robert P</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEMS microbiology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Stephen G.J</au><au>Mahon, Vivienne</au><au>Lambert, Matthew A</au><au>Fagan, Robert P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>molecular Swiss army knife: OmpA structure, function and expression</atitle><jtitle>FEMS microbiology letters</jtitle><addtitle>FEMS Microbiol Lett</addtitle><date>2007-08</date><risdate>2007</risdate><volume>273</volume><issue>1</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>0378-1097</issn><eissn>1574-6968</eissn><coden>FMLED7</coden><abstract>The OmpA outer membrane protein of Escherichia coli and other enterobacteria is a multifaceted protein. This protein is expressed to very high levels and ompA is tightly regulated at the posttranscriptional level. It can function as an adhesin and invasin, participate in biofilm formation, act as both an immune target and evasin, and serves as a receptor for several bacteriophages. Many of these properties are due to four short protein loops that emanate from the protein to the outside of the cell. Herein it is described how the structure of this protein relates to its many functions.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>17559395</pmid><doi>10.1111/j.1574-6968.2007.00778.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEMS microbiology letters, 2007-08, Vol.273 (1), p.1-11 |
| issn | 0378-1097 1574-6968 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | adhesion Amino Acid Sequence Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Bacterial Outer Membrane Proteins - physiology Bacteriology Biofilms Biological and medical sciences E coli Escherichia coli Escherichia coli - chemistry Escherichia coli - physiology Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - immunology Escherichia coli Proteins - physiology Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Bacterial Genetics immune evasion invasion Membrane proteins Microbiology Models, Molecular Molecular and cellular biology Molecular genetics Molecular Sequence Data Molecular structure OmpA outer membrane protein Phages pore-forming protein Post-transcription Protein structure Proteins Structure-function relationships β-barrel |
| title | molecular Swiss army knife: OmpA structure, function and expression |
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