Influence of CYP3A5 gene polymorphisms of donor rather than recipient to tacrolimus individual dose requirement in liver transplantation

Tacrolimus is a widely used immunosuppressant in organ transplantation, but it is characterized by a narrow therapeutic index and high interindividual variations of its pharmacokinetics. Tacrolimus is a substrate for CYP3A. It has been conjectured that CYP3A5 polymorphism is associated with tacrolim...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Transplantation 2006-01, Vol.81 (1), p.46-51
Hauptverfasser:	Yu, Songfeng, Wu, Lihua, Jin, Jing, Yan, Sheng, Jiang, Guoping, Xie, Haiyang, Zheng, Shusen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - genetics Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Fundamental immunology Genotype Humans Liver Transplantation - immunology Medical sciences Middle Aged Pharmacology. Drug treatments Polymorphism, Genetic - genetics Retrospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tacrolimus - administration & dosage Tacrolimus - pharmacokinetics Tissue Donors Tissue, organ and graft immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!