Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites
Several polyketide secondary metabolites are shown by feeding experiments to incorporate glycerol-derived 3-carbon starter units, 2-carbon extender units, or 3-carbon branches into their hydrocarbon chains. In recent years, genetic studies have begun to elucidate the mechanisms by which this occurs....
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| Veröffentlicht in: | Journal of industrial microbiology & biotechnology 2006-02, Vol.33 (2), p.105-120 |
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| container_title | Journal of industrial microbiology & biotechnology |
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| creator | WALTON, Laura J CORRE, Christophe CHALLIS, Gregory L |
| description | Several polyketide secondary metabolites are shown by feeding experiments to incorporate glycerol-derived 3-carbon starter units, 2-carbon extender units, or 3-carbon branches into their hydrocarbon chains. In recent years, genetic studies have begun to elucidate the mechanisms by which this occurs. In this article we review the incorporation of glycerol-derived precursors into polyketides and propose new mechanisms for the incorporation processes. |
| doi_str_mv | 10.1007/s10295-005-0026-7 |
| format | Article |
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| ispartof | Journal of industrial microbiology & biotechnology, 2006-02, Vol.33 (2), p.105-120 |
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| source | MEDLINE; SpringerLink; Oxford Academic Journals (Open Access) |
| subjects | Bacteria Biological and medical sciences Biotechnology Carbon Fundamental and applied biological sciences. Psychology Glycerol Glycerol - metabolism Incorporation Macrolides - chemistry Macrolides - metabolism Metabolites Polyketide Synthases Secondary metabolites Streptomyces - enzymology Streptomyces - metabolism |
| title | Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites |
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