In Vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae)
In this study the methanol/dichloromethane (1:1) extract and plumbagin isolated from extract of stem barks of Diospyros crassiflora were tested for their antifungal activity against 12 strains of yeast pathogens and filamentous fungi: Candida albicans, Candida glabrata, Candida krusei, Candida tropi...
Gespeichert in:
| Veröffentlicht in: | Phytotherapy research 2007-07, Vol.21 (7), p.671-674 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 674 |
|---|---|
| container_issue | 7 |
| container_start_page | 671 |
| container_title | Phytotherapy research |
| container_volume | 21 |
| creator | Dzoyem, J. P. Tangmouo, J. G. Lontsi, D. Etoa, F. X. Lohoue, P. J. |
| description | In this study the methanol/dichloromethane (1:1) extract and plumbagin isolated from extract of stem barks of Diospyros crassiflora were tested for their antifungal activity against 12 strains of yeast pathogens and filamentous fungi: Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis, Cryptococcus neoformans, Aspergillus niger, Aspergillus flavus, Alternaria sp., Cladosporium sp., Geotrichum candidum, Fusarium sp. and Penicillium sp. The growth of all fungi strains tested was inhibited by the extract and plumbagin. The diameter of inhibition zones varied from 12 to 18 mm and from 21 to 35 mm for the extract and plumbagin, respectively. The MIC values ranged from 12.5 to 25 mg/mL for the extract and 0.78–3.12 µg/mL for plumbagin. It is therefore suggested that extracts from the stem bark of Diospyros crassiflora could be used traditionally in the treatment of fungal infections. Compared with ketoconazole used as a standard antifungal, plumbagin could be considered as a promising antifungal agent. Copyright © 2007 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.2140 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70676085</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70676085</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4530-fa0f973cbb8944dec1f3ca173447bfc6b5ecbd11b29b7df2b7f0bc716c056a933</originalsourceid><addsrcrecordid>eNp10E1rFTEUgOEgir22gr9AslHqYmoyyUxmlmXsF5Rayq0WN-Ekk9TofJlkau-_N5c7tCtXIeThnPAi9I6SI0pI_nmK_iinnLxAK0rqOqOFYC_RitQFzTit7vbQmxB-EULqnPDXaI8KznkhihUKFwP-5qIfMQzR2Xm4hw6Dju7BxQ0eLTaP0ad7em7x1M29gns3YOvHHsefBodoeqzA_97aL24M08aPAWsPITjbjR7wuTN-wIcnygygDZhPB-iVhS6Yt8u5j25PT9bNeXb59eyiOb7MNC8YySwQWwumlapqzlujqWUaqGCcC2V1qQqjVUupymslWpsrYYnSgpaaFCXUjO2jj7u5kx__zCZE2bugTdfBYMY5SEFKUZKqSPBwB3X6e_DGysm7HvxGUiK3gWUKLLeBE32_zJxVb9pnuBRN4MMCIGjorIdBu_DsqkqInPPksp376zqz-e9Ceb2-WRYv3qXkj08-lZelYKKQ36_O5M36R3N33TSSsX8ltqKk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70676085</pqid></control><display><type>article</type><title>In Vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae)</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Dzoyem, J. P. ; Tangmouo, J. G. ; Lontsi, D. ; Etoa, F. X. ; Lohoue, P. J.</creator><creatorcontrib>Dzoyem, J. P. ; Tangmouo, J. G. ; Lontsi, D. ; Etoa, F. X. ; Lohoue, P. J.</creatorcontrib><description>In this study the methanol/dichloromethane (1:1) extract and plumbagin isolated from extract of stem barks of Diospyros crassiflora were tested for their antifungal activity against 12 strains of yeast pathogens and filamentous fungi: Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis, Cryptococcus neoformans, Aspergillus niger, Aspergillus flavus, Alternaria sp., Cladosporium sp., Geotrichum candidum, Fusarium sp. and Penicillium sp. The growth of all fungi strains tested was inhibited by the extract and plumbagin. The diameter of inhibition zones varied from 12 to 18 mm and from 21 to 35 mm for the extract and plumbagin, respectively. The MIC values ranged from 12.5 to 25 mg/mL for the extract and 0.78–3.12 µg/mL for plumbagin. It is therefore suggested that extracts from the stem bark of Diospyros crassiflora could be used traditionally in the treatment of fungal infections. Compared with ketoconazole used as a standard antifungal, plumbagin could be considered as a promising antifungal agent. Copyright © 2007 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.2140</identifier><identifier>PMID: 17444575</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>antifungal activity ; Antifungal Agents - administration & dosage ; Antifungal Agents - pharmacology ; Antifungal Agents - therapeutic use ; Biological and medical sciences ; Diospyros ; Diospyros crassiflora ; Ebenaceae ; General pharmacology ; Humans ; Medical sciences ; Microbial Sensitivity Tests ; Mitosporic Fungi - drug effects ; Naphthoquinones - administration & dosage ; Naphthoquinones - pharmacology ; Naphthoquinones - therapeutic use ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Stems ; plumbagin</subject><ispartof>Phytotherapy research, 2007-07, Vol.21 (7), p.671-674</ispartof><rights>Copyright © 2007 John Wiley & Sons, Ltd.</rights><rights>2007 INIST-CNRS</rights><rights>Copyright 2007 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4530-fa0f973cbb8944dec1f3ca173447bfc6b5ecbd11b29b7df2b7f0bc716c056a933</citedby><cites>FETCH-LOGICAL-c4530-fa0f973cbb8944dec1f3ca173447bfc6b5ecbd11b29b7df2b7f0bc716c056a933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.2140$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.2140$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18877244$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17444575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dzoyem, J. P.</creatorcontrib><creatorcontrib>Tangmouo, J. G.</creatorcontrib><creatorcontrib>Lontsi, D.</creatorcontrib><creatorcontrib>Etoa, F. X.</creatorcontrib><creatorcontrib>Lohoue, P. J.</creatorcontrib><title>In Vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae)</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>In this study the methanol/dichloromethane (1:1) extract and plumbagin isolated from extract of stem barks of Diospyros crassiflora were tested for their antifungal activity against 12 strains of yeast pathogens and filamentous fungi: Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis, Cryptococcus neoformans, Aspergillus niger, Aspergillus flavus, Alternaria sp., Cladosporium sp., Geotrichum candidum, Fusarium sp. and Penicillium sp. The growth of all fungi strains tested was inhibited by the extract and plumbagin. The diameter of inhibition zones varied from 12 to 18 mm and from 21 to 35 mm for the extract and plumbagin, respectively. The MIC values ranged from 12.5 to 25 mg/mL for the extract and 0.78–3.12 µg/mL for plumbagin. It is therefore suggested that extracts from the stem bark of Diospyros crassiflora could be used traditionally in the treatment of fungal infections. Compared with ketoconazole used as a standard antifungal, plumbagin could be considered as a promising antifungal agent. Copyright © 2007 John Wiley & Sons, Ltd.</description><subject>antifungal activity</subject><subject>Antifungal Agents - administration & dosage</subject><subject>Antifungal Agents - pharmacology</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Diospyros</subject><subject>Diospyros crassiflora</subject><subject>Ebenaceae</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Mitosporic Fungi - drug effects</subject><subject>Naphthoquinones - administration & dosage</subject><subject>Naphthoquinones - pharmacology</subject><subject>Naphthoquinones - therapeutic use</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Stems</subject><subject>plumbagin</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1rFTEUgOEgir22gr9AslHqYmoyyUxmlmXsF5Rayq0WN-Ekk9TofJlkau-_N5c7tCtXIeThnPAi9I6SI0pI_nmK_iinnLxAK0rqOqOFYC_RitQFzTit7vbQmxB-EULqnPDXaI8KznkhihUKFwP-5qIfMQzR2Xm4hw6Dju7BxQ0eLTaP0ad7em7x1M29gns3YOvHHsefBodoeqzA_97aL24M08aPAWsPITjbjR7wuTN-wIcnygygDZhPB-iVhS6Yt8u5j25PT9bNeXb59eyiOb7MNC8YySwQWwumlapqzlujqWUaqGCcC2V1qQqjVUupymslWpsrYYnSgpaaFCXUjO2jj7u5kx__zCZE2bugTdfBYMY5SEFKUZKqSPBwB3X6e_DGysm7HvxGUiK3gWUKLLeBE32_zJxVb9pnuBRN4MMCIGjorIdBu_DsqkqInPPksp376zqz-e9Ceb2-WRYv3qXkj08-lZelYKKQ36_O5M36R3N33TSSsX8ltqKk</recordid><startdate>200707</startdate><enddate>200707</enddate><creator>Dzoyem, J. P.</creator><creator>Tangmouo, J. G.</creator><creator>Lontsi, D.</creator><creator>Etoa, F. X.</creator><creator>Lohoue, P. J.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200707</creationdate><title>In Vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae)</title><author>Dzoyem, J. P. ; Tangmouo, J. G. ; Lontsi, D. ; Etoa, F. X. ; Lohoue, P. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4530-fa0f973cbb8944dec1f3ca173447bfc6b5ecbd11b29b7df2b7f0bc716c056a933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>antifungal activity</topic><topic>Antifungal Agents - administration & dosage</topic><topic>Antifungal Agents - pharmacology</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Diospyros</topic><topic>Diospyros crassiflora</topic><topic>Ebenaceae</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Mitosporic Fungi - drug effects</topic><topic>Naphthoquinones - administration & dosage</topic><topic>Naphthoquinones - pharmacology</topic><topic>Naphthoquinones - therapeutic use</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Stems</topic><topic>plumbagin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dzoyem, J. P.</creatorcontrib><creatorcontrib>Tangmouo, J. G.</creatorcontrib><creatorcontrib>Lontsi, D.</creatorcontrib><creatorcontrib>Etoa, F. X.</creatorcontrib><creatorcontrib>Lohoue, P. J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dzoyem, J. P.</au><au>Tangmouo, J. G.</au><au>Lontsi, D.</au><au>Etoa, F. X.</au><au>Lohoue, P. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae)</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2007-07</date><risdate>2007</risdate><volume>21</volume><issue>7</issue><spage>671</spage><epage>674</epage><pages>671-674</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>In this study the methanol/dichloromethane (1:1) extract and plumbagin isolated from extract of stem barks of Diospyros crassiflora were tested for their antifungal activity against 12 strains of yeast pathogens and filamentous fungi: Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis, Cryptococcus neoformans, Aspergillus niger, Aspergillus flavus, Alternaria sp., Cladosporium sp., Geotrichum candidum, Fusarium sp. and Penicillium sp. The growth of all fungi strains tested was inhibited by the extract and plumbagin. The diameter of inhibition zones varied from 12 to 18 mm and from 21 to 35 mm for the extract and plumbagin, respectively. The MIC values ranged from 12.5 to 25 mg/mL for the extract and 0.78–3.12 µg/mL for plumbagin. It is therefore suggested that extracts from the stem bark of Diospyros crassiflora could be used traditionally in the treatment of fungal infections. Compared with ketoconazole used as a standard antifungal, plumbagin could be considered as a promising antifungal agent. Copyright © 2007 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>17444575</pmid><doi>10.1002/ptr.2140</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0951-418X |
| ispartof | Phytotherapy research, 2007-07, Vol.21 (7), p.671-674 |
| issn | 0951-418X 1099-1573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70676085 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | antifungal activity Antifungal Agents - administration & dosage Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Biological and medical sciences Diospyros Diospyros crassiflora Ebenaceae General pharmacology Humans Medical sciences Microbial Sensitivity Tests Mitosporic Fungi - drug effects Naphthoquinones - administration & dosage Naphthoquinones - pharmacology Naphthoquinones - therapeutic use Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Stems plumbagin |
| title | In Vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T08%3A35%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20Vitro%20antifungal%20activity%20of%20extract%20and%20plumbagin%20from%20the%20stem%20bark%20of%20Diospyros%20crassiflora%20Hiern%20(Ebenaceae)&rft.jtitle=Phytotherapy%20research&rft.au=Dzoyem,%20J.%20P.&rft.date=2007-07&rft.volume=21&rft.issue=7&rft.spage=671&rft.epage=674&rft.pages=671-674&rft.issn=0951-418X&rft.eissn=1099-1573&rft_id=info:doi/10.1002/ptr.2140&rft_dat=%3Cproquest_cross%3E70676085%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70676085&rft_id=info:pmid/17444575&rfr_iscdi=true |