Fibronectin as target for tumor therapy

During cancer progression, the extracellular matrix (ECM) of the tissue in which the tumor grows is extensively remodeled, both by degradation of preexisting ECM molecules and by the neosynthesis of ECM components, which in many cases are not present in the ECM of normal tissues. Fibronectin (FN), a...

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Veröffentlicht in:	International journal of cancer 2006-03, Vol.118 (6), p.1331-1339
Hauptverfasser:	Kaspar, Manuela, Zardi, Luciano, Neri, Dario
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Antibodies - therapeutic use Biological and medical sciences Clinical Trials as Topic Drug Screening Assays, Antitumor ECM EDB fibronectin Fibronectins - antagonists & inhibitors Fibronectins - immunology Fibronectins - metabolism Humans Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - drug therapy Neoplasms - metabolism Tumors vascular tumor targeting
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