Bevacizumab-Induced Transient Remodeling of the Vasculature in Neuroblastoma Xenografts Results in Improved Delivery and Efficacy of Systemically Administered Chemotherapy

Purpose: Dysfunctional tumor vessels can be a significant barrier to effective cancer therapy. However, increasing evidence suggests that vascular endothelial growth factor (VEGF) inhibition can effect transient “normalization” of the tumor vasculature, thereby improving tumor perfusion and, consequ...

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Veröffentlicht in:	Clinical cancer research 2007-07, Vol.13 (13), p.3942-3950
Hauptverfasser:	Dickson, Paxton V, Hamner, John B, Sims, Thomas L, Fraga, Charles H, Ng, Catherine Y C, Rajasekeran, Surender, Hagedorn, Nikolaus L, McCarville, M Beth, Stewart, Clinton F, Davidoff, Andrew M
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - pharmacology Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Bevacizumab Cell Line, Tumor Humans Male Mice Microcirculation Neoplasm Transplantation Neovascularization, Pathologic neuroblastoma Neuroblastoma - drug therapy Neuroblastoma - metabolism Neuroblastoma - pathology normalization Phenotype Pressure Vascular Endothelial Growth Factor A - chemistry Vascular Endothelial Growth Factor A - metabolism vasculature
Online-Zugang:	Volltext
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