Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo

Considerable research effort is currently being directed towards understanding the mechanisms mediating the antiproliferative effects of non-steroidal anti-inflammatory drugs (NSAIDs) and, more recently, of cyclooxygenase (COX)-2 inhibitors as well. A key question is whether NSAIDs (excluding sulind...

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Veröffentlicht in:	Biochemical pharmacology 2001-03, Vol.61 (5), p.565-571
Hauptverfasser:	Eli, Yaniv, Przedecki, Fiorenza, Levin, Galit, Kariv, Na’am, Raz, Amiram
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cachexia - prevention & control Cell cycle Cell Cycle - drug effects Cell Division - drug effects Cell proliferation Cell Survival - drug effects Cyclooxygenase 1 Cyclooxygenases Disease Models, Animal General aspects Indomethacin Indomethacin - pharmacology Indomethacin - therapeutic use Isoenzymes - drug effects Isoenzymes - metabolism Lung Neoplasms - prevention & control Lung Neoplasms - secondary Male Medical sciences Membrane Proteins Mice Mice, Inbred C57BL Neoplasm Transplantation NSAIDs Pharmacology. Drug treatments Prostaglandin-Endoperoxide Synthases - drug effects Prostaglandin-Endoperoxide Synthases - metabolism Tumor cells Tumor Cells, Cultured
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