Nanoparticles of hydrophobically modified dextrans as potential drug carrier systems
Nanoparticles combining a hydrophobically modified dextran core and a polysaccharide surface coverage were elaborated. Their suitability for applications like drug delivery was evaluated. The selected polysaccharide, dextran, was chemically modified by the covalent attachment of hydrocarbon groups (...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2007-09, Vol.59 (1), p.74-80 |
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| container_title | Colloids and surfaces, B, Biointerfaces |
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| creator | Aumelas, A. Serrero, A. Durand, A. Dellacherie, E. Leonard, M. |
| description | Nanoparticles combining a hydrophobically modified dextran core and a polysaccharide surface coverage were elaborated. Their suitability for applications like drug delivery was evaluated. The selected polysaccharide, dextran, was chemically modified by the covalent attachment of hydrocarbon groups (aliphatic or aromatic) via the formation of ether links. According to the extent of modification, either water-soluble or water-insoluble dextran derivatives were obtained. The latter exhibited solubility in organic solvents like tetrahydrofuran or dichloromethane saturated with water. Water-soluble dextran derivatives were used as polymeric surfactants for the control of nanoparticles surface characteristics. Nanoparticles were prepared either by o/w emulsion or solvent-diffusion methods. The size and surface properties of dextran nanoparticles were correlated to processing conditions. The stability of colloidal suspensions was examined as a function of ionic strength and related to the particle surface characteristics. The redispersability of freeze-dried suspensions without the addition of cryoprotectant was demonstrated. Finally, the degradability of modified dextrans was compared to that of starting dextran, after enzymatic hydrolysis in the presence of dextranase. |
| doi_str_mv | 10.1016/j.colsurfb.2007.04.021 |
| format | Article |
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Their suitability for applications like drug delivery was evaluated. The selected polysaccharide, dextran, was chemically modified by the covalent attachment of hydrocarbon groups (aliphatic or aromatic) via the formation of ether links. According to the extent of modification, either water-soluble or water-insoluble dextran derivatives were obtained. The latter exhibited solubility in organic solvents like tetrahydrofuran or dichloromethane saturated with water. Water-soluble dextran derivatives were used as polymeric surfactants for the control of nanoparticles surface characteristics. Nanoparticles were prepared either by o/w emulsion or solvent-diffusion methods. The size and surface properties of dextran nanoparticles were correlated to processing conditions. The stability of colloidal suspensions was examined as a function of ionic strength and related to the particle surface characteristics. The redispersability of freeze-dried suspensions without the addition of cryoprotectant was demonstrated. Finally, the degradability of modified dextrans was compared to that of starting dextran, after enzymatic hydrolysis in the presence of dextranase.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2007.04.021</identifier><identifier>PMID: 17560095</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Colloids ; Dextranase - metabolism ; Dextrans - chemical synthesis ; Dextrans - chemistry ; Dextrans - metabolism ; Drug Carriers - chemical synthesis ; Drug Carriers - chemistry ; Drug Carriers - metabolism ; Drug Stability ; Emulsion ; Emulsions ; Freeze Drying ; Hydrophobic and Hydrophilic Interactions ; Hydrophobically modified dextran ; In Vitro Techniques ; Materials Testing ; Models, Molecular ; Molecular Structure ; Nanoparticles ; Nanoparticles - chemistry ; Nanoprecipitation ; Particle Size ; Solvents ; Surface Properties</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2007-09, Vol.59 (1), p.74-80</ispartof><rights>2007 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-5bc3857e4dfb9b039de2e053e9e25d58a77856d118494605690a4aa3eb1aec8e3</citedby><cites>FETCH-LOGICAL-c397t-5bc3857e4dfb9b039de2e053e9e25d58a77856d118494605690a4aa3eb1aec8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.colsurfb.2007.04.021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17560095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aumelas, A.</creatorcontrib><creatorcontrib>Serrero, A.</creatorcontrib><creatorcontrib>Durand, A.</creatorcontrib><creatorcontrib>Dellacherie, E.</creatorcontrib><creatorcontrib>Leonard, M.</creatorcontrib><title>Nanoparticles of hydrophobically modified dextrans as potential drug carrier systems</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>Nanoparticles combining a hydrophobically modified dextran core and a polysaccharide surface coverage were elaborated. Their suitability for applications like drug delivery was evaluated. The selected polysaccharide, dextran, was chemically modified by the covalent attachment of hydrocarbon groups (aliphatic or aromatic) via the formation of ether links. According to the extent of modification, either water-soluble or water-insoluble dextran derivatives were obtained. The latter exhibited solubility in organic solvents like tetrahydrofuran or dichloromethane saturated with water. Water-soluble dextran derivatives were used as polymeric surfactants for the control of nanoparticles surface characteristics. Nanoparticles were prepared either by o/w emulsion or solvent-diffusion methods. The size and surface properties of dextran nanoparticles were correlated to processing conditions. The stability of colloidal suspensions was examined as a function of ionic strength and related to the particle surface characteristics. The redispersability of freeze-dried suspensions without the addition of cryoprotectant was demonstrated. Finally, the degradability of modified dextrans was compared to that of starting dextran, after enzymatic hydrolysis in the presence of dextranase.</description><subject>Colloids</subject><subject>Dextranase - metabolism</subject><subject>Dextrans - chemical synthesis</subject><subject>Dextrans - chemistry</subject><subject>Dextrans - metabolism</subject><subject>Drug Carriers - chemical synthesis</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - metabolism</subject><subject>Drug Stability</subject><subject>Emulsion</subject><subject>Emulsions</subject><subject>Freeze Drying</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Hydrophobically modified dextran</subject><subject>In Vitro Techniques</subject><subject>Materials Testing</subject><subject>Models, Molecular</subject><subject>Molecular Structure</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoprecipitation</subject><subject>Particle Size</subject><subject>Solvents</subject><subject>Surface Properties</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1v1DAQgGELgehS-AuVT9wSxnbsSW6gii-pgks5W449oV4lcbATxP57Uu0ijj3N5Z0Z6WHsRkAtQJh3x9qnsWx56GsJgDU0NUjxjB1Ei6pqlMHn7ACdxArR6Cv2qpQjAMhG4Et2JVAbgE4f2P03N6fF5TX6kQpPA384hZyWh9RH78bxxKcU4hAp8EB_1uzmwl3hS1ppXqMbecjbT-5dzpEyL6ey0lResxeDGwu9ucxr9uPTx_vbL9Xd989fbz_cVV51uFa696rVSE0Y-q4H1QWSBFpRR1IH3TrEVpsgRNt0jQFtOnCNc4p64ci3pK7Z2_PdJadfG5XVTrF4Gkc3U9qKRTCoJIgnQwkoQSPuoTmHPqdSMg12yXFy-WQF2Ed4e7T_4O0jvIXG7vD74s3lw9ZPFP6vXaT34P05oB3k945li480ewoxk19tSPGpH38B97WZbQ</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Aumelas, A.</creator><creator>Serrero, A.</creator><creator>Durand, A.</creator><creator>Dellacherie, E.</creator><creator>Leonard, M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Nanoparticles of hydrophobically modified dextrans as potential drug carrier systems</title><author>Aumelas, A. ; Serrero, A. ; Durand, A. ; Dellacherie, E. ; Leonard, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-5bc3857e4dfb9b039de2e053e9e25d58a77856d118494605690a4aa3eb1aec8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Colloids</topic><topic>Dextranase - metabolism</topic><topic>Dextrans - chemical synthesis</topic><topic>Dextrans - chemistry</topic><topic>Dextrans - metabolism</topic><topic>Drug Carriers - chemical synthesis</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - metabolism</topic><topic>Drug Stability</topic><topic>Emulsion</topic><topic>Emulsions</topic><topic>Freeze Drying</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Hydrophobically modified dextran</topic><topic>In Vitro Techniques</topic><topic>Materials Testing</topic><topic>Models, Molecular</topic><topic>Molecular Structure</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoprecipitation</topic><topic>Particle Size</topic><topic>Solvents</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aumelas, A.</creatorcontrib><creatorcontrib>Serrero, A.</creatorcontrib><creatorcontrib>Durand, A.</creatorcontrib><creatorcontrib>Dellacherie, E.</creatorcontrib><creatorcontrib>Leonard, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aumelas, A.</au><au>Serrero, A.</au><au>Durand, A.</au><au>Dellacherie, E.</au><au>Leonard, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nanoparticles of hydrophobically modified dextrans as potential drug carrier systems</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>59</volume><issue>1</issue><spage>74</spage><epage>80</epage><pages>74-80</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>Nanoparticles combining a hydrophobically modified dextran core and a polysaccharide surface coverage were elaborated. Their suitability for applications like drug delivery was evaluated. The selected polysaccharide, dextran, was chemically modified by the covalent attachment of hydrocarbon groups (aliphatic or aromatic) via the formation of ether links. According to the extent of modification, either water-soluble or water-insoluble dextran derivatives were obtained. The latter exhibited solubility in organic solvents like tetrahydrofuran or dichloromethane saturated with water. Water-soluble dextran derivatives were used as polymeric surfactants for the control of nanoparticles surface characteristics. Nanoparticles were prepared either by o/w emulsion or solvent-diffusion methods. The size and surface properties of dextran nanoparticles were correlated to processing conditions. The stability of colloidal suspensions was examined as a function of ionic strength and related to the particle surface characteristics. 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| ispartof | Colloids and surfaces, B, Biointerfaces, 2007-09, Vol.59 (1), p.74-80 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Colloids Dextranase - metabolism Dextrans - chemical synthesis Dextrans - chemistry Dextrans - metabolism Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Carriers - metabolism Drug Stability Emulsion Emulsions Freeze Drying Hydrophobic and Hydrophilic Interactions Hydrophobically modified dextran In Vitro Techniques Materials Testing Models, Molecular Molecular Structure Nanoparticles Nanoparticles - chemistry Nanoprecipitation Particle Size Solvents Surface Properties |
| title | Nanoparticles of hydrophobically modified dextrans as potential drug carrier systems |
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