Histone Deacetylase Inhibitors Affect Dendritic Cell Differentiation and Immunogenicity

Purpose: Histone deacetylases (HDAC) modulate gene transcription and chromatin assembly by modifying histones at the posttranscriptional level. HDAC inhibitors have promising antitumor activity and are presently explored in clinical studies. Cumulating evidence in animal models of immune disorders a...

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Veröffentlicht in:	Clinical cancer research 2007-07, Vol.13 (13), p.3933-3941
Hauptverfasser:	Nencioni, Alessio, Beck, Julia, Werth, Daniela, Grünebach, Frank, Patrone, Franco, Ballestrero, Alberto, Brossart, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Antineoplastic agents Benzamides - pharmacology Biological and medical sciences Cell Differentiation Cell Nucleus - metabolism cellular immunotherapy Dendritic Cells - cytology Dendritic Cells - enzymology Dendritic Cells - immunology Enzyme Inhibitors - pharmacology Histone Deacetylase Inhibitors Humans Immune System immunomodulation Immunosuppressive Agents - pharmacology Interferon Regulatory Factor-3 - metabolism Interferon Regulatory Factors - metabolism lymphokines, cytokines, chemokines, and growth factors Medical sciences Monocytes - cytology Monocytes - immunology Monocytes - metabolism Pharmacology. Drug treatments Pyridines - pharmacology Transcription Factor RelB - metabolism Valproic Acid - pharmacology
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