Ocular Gene Transfer with Self-Complementary AAV Vectors

Self-complementary AAV (scAAV) vectors have been developed to circumvent rate-limiting second-strand synthesis in single-stranded AAV vector genomes and to facilitate robust transgene expression at a minimal dose. In this study, the authors investigated the effects of intraocular injections of type...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2007-07, Vol.48 (7), p.3324-3328
Hauptverfasser:	Yokoi, Katsutoshi, Kachi, Shu, Zhang, H. Steve, Gregory, Philip D, Spratt, S. Kaye, Samulski, R. Jude, Campochiaro, Peter A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dependovirus - genetics Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Gene Transfer Techniques Genetic Therapy Genetic Vectors Green Fluorescent Proteins - genetics Mice Mice, Inbred BALB C Microscopy, Fluorescence Pigment Epithelium of Eye - metabolism Plasmids Transgenes Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
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