Determination of in vivo adducts of disulfiram with mitochondrial aldehyde dehydrogenase

Extensive use for disulfiram (DSF) has been found in the aversion therapy treatment of recovering alcoholics. Although it is known to irreversibly inhibit hepatic aldehyde dehydrogenase (ALDH), the specific mechanism of in vivo inhibition of the enzyme by the drug has not been determined yet. We hav...

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Veröffentlicht in:	Biochemical pharmacology 2001-03, Vol.61 (5), p.537-545
Hauptverfasser:	Shen, Maryann L, Johnson, Kenneth L, Mays, Dennis C, Lipsky, James J, Naylor, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Deterrents - analysis Alcohol Deterrents - chemistry Aldehyde dehydrogenase Aldehyde Dehydrogenase - analysis Aldehyde Dehydrogenase - chemistry Aldehyde Dehydrogenase - metabolism Amino Acid Sequence Analysis Animals Biological and medical sciences Chromatography, High Pressure Liquid Disulfiram Disulfiram - analysis Disulfiram - chemistry General pharmacology In vivo enzyme inhibition Mass Spectrometry Medical sciences Mitochondria, Liver - enzymology Pepsin A - metabolism Peptides - analysis Peptides - chemistry Pharmacology. Drug treatments Protein Processing, Post-Translational Protein–drug interactions Rats
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