Bullous pemphigoid antigen II (BP180) and its soluble extracellular domains are major autoantigens in mucous membrane pemphigoid: the pathogenic relevance to HLA class II alleles and disease severity

Summary Background Mucous membrane pemphigoid (MMP), a chronic autoimmune subepithelial blistering disease, is associated with circulating IgG and/or IgA autoantibodies against several basement membrane zone antigens. The heterogeneity of clinical presentation and diversity of target autoantigens h...

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Veröffentlicht in:	British journal of dermatology (1951) 2006-01, Vol.154 (1), p.90-98
Hauptverfasser:	Oyama, N., Setterfield, J.F., Powell, A.M., Sakuma-Oyama, Y., Albert, S., Bhogal, B.S., Vaughan, R.W., Kaneko, F., Challacombe, S.J., Black, M.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles Autoantibodies - blood Autoantigens - analysis Autoantigens - immunology Basement Membrane - immunology basement membrane zone antigens Biological and medical sciences Bullous diseases of the skin bullous pemphigoid Carrier Proteins cicatricial pemphigoid Collagen Type XVII Cytoskeletal Proteins Dermatology Dystonin Female Genes, MHC Class II Humans Immunoblotting Immunoglobulin A - blood Immunoglobulin G - blood immunoglobulin isotype Laminin - immunology linear IgA bullous dermatosis Male Medical sciences Microscopy, Fluorescence Middle Aged Nerve Tissue Proteins Non-Fibrillar Collagens Pemphigoid, Benign Mucous Membrane - genetics Pemphigoid, Benign Mucous Membrane - immunology Phenotype Severity of Illness Index Skin - immunology
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