The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeleton

The lack of neurofibromatosis 2 tumor suppressor protein merlin leads to the formation of nervous system tumors, specifically schwannomas and meningiomas. Merlin is considered to act as a tumor suppressor at the cell membrane, where it links transmembrane receptors to the actin cytoskeleton. Several...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human molecular genetics 2007-07, Vol.16 (14), p.1742-1751
Hauptverfasser:	Muranen, Taru, Grönholm, Mikaela, Lampin, Aurelie, Lallemand, Dominique, Zhao, Fang, Giovannini, Marco, Carpén, Olli
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cattle Cell Line, Tumor Cell physiology Cell structures and functions Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cytoskeleton - metabolism Cytoskeleton, cytoplasm. Intracellular movements Escherichia coli - metabolism Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Glioma - metabolism Humans Insecta Mice Microtubules - metabolism Models, Biological Molecular and cellular biology Neurofibromin 2 - genetics Neurofibromin 2 - metabolism Neurofibromin 2 - physiology Protein Isoforms Schwann Cells - metabolism Tubulin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!