IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain—containing protein tyrosine phosphatase 1

Background Specific T-cell activation requires T-cell receptor stimulation and the generation of costimulatory signals. Major costimulatory signals are delivered to T cells by the interaction of CD28 and inducible costimulator (ICOS). Objective To investigate the molecular pathways involved in direc...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2007-07, Vol.120 (1), p.76-83
Hauptverfasser:	Taylor, Alison, PhD, Akdis, Mübeccel, MD, PhD, Joss, Andrea, PhD, Akkoç, Tunç, PhD, Wenig, Renate, PhD, Colonna, Marco, MD, Daigle, Isabelle, PhD, Flory, Egbert, PhD, Blaser, Kurt, PhD, Akdis, Cezmi A., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology anergy Animals Antigens, Differentiation, T-Lymphocyte - metabolism Biological and medical sciences Biotechnology CD28 Antigens - metabolism Cells, Cultured Cloning costimulation Fundamental and applied biological sciences. Psychology Fundamental immunology Humans IL-10 Immune system Inducible T-Cell Co-Stimulator Protein inhibition Interleukin-10 - pharmacology Kinases Ligands Lymphocyte Activation Lymphocytes Medical sciences Mice Mutation Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein Phosphatase 1 Protein Tyrosine Phosphatase, Non-Receptor Type 6 - antagonists & inhibitors Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism Proteins RNA Interference Rodents Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis SHP-1 suppression T cell T cell receptors T-Lymphocytes - enzymology T-Lymphocytes - immunology Tetanus tolerance
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