Superiority of gas chromatography/tandem mass spectrometry assay (GC/MS/MS) for estradiol for monitoring of aromatase inhibitor therapy

Currently available radioimmunoassay methods for estradiol in serum lack sufficient sensitivity and precision to monitor estradiol levels in patients placed on third generation aromatase inhibitors. We recently validated a gas chromatography/tandem mass spectrometry assay (GC/MS/MS) for estradiol an...

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Veröffentlicht in:	Steroids 2007-07, Vol.72 (8), p.666-671
Hauptverfasser:	Santen, Richard J., Demers, Lawrence, Ohorodnik, Susan, Settlage, J., Langecker, Peter, Blanchett, D., Goss, Paul E., Wang, Shuping
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstenedione - analogs & derivatives Androstenedione - therapeutic use Aromatase inhibitor Aromatase Inhibitors - therapeutic use Biological and medical sciences Biological Assay Breast cancer Breast Neoplasms - blood Breast Neoplasms - drug therapy Estradiol Estradiol - blood Female Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry GC/tandem mass spectrometry Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Nitriles - therapeutic use Placebos Postmenopause Radioimmunoassay Sensitivity and Specificity Tandem Mass Spectrometry Triazoles - therapeutic use Tumors Vertebrates: endocrinology
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