Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease
Controversy exists as to whether the deletion/deletion (DD) genotype of angiotensin l-converting enzyme (ACE) gene polymorphism is associated with coronary heart disease (CHD). There are only a few studies dealing with this issue in the elderly, also with controversial results. The aim of this study...
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| Veröffentlicht in: | Collegium antropologicum 2007-03, Vol.31 (1), p.179-183 |
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| container_title | Collegium antropologicum |
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| creator | Marković, Biserka Bergman Bergovec, Mijo Reiner, Zeljko Sertić, Jadranka Vincelj, Josip Marković, Maja |
| description | Controversy exists as to whether the deletion/deletion (DD) genotype of angiotensin l-converting enzyme (ACE) gene polymorphism is associated with coronary heart disease (CHD). There are only a few studies dealing with this issue in the elderly, also with controversial results. The aim of this study was the assessment of correlation between genetic markers and the risk of CHD in the elderly. The results indicated DD genotype importance for CHD in the elderly as proven by discriminant analysis (chi2 = 25.77; df = 16; p = 0.0620). However, the use of univariate method demonstrated no correlation between DD genotype of ACE gene polymorphism and coronary artery disease. D allele of ACE gene was associated with higher activities of ACE plasma. A weak, but increased risk of MI is associated with high frequency of DD genotype in the elderly. Strong correlation between ACE polymorphism and ACE plasma activities was demonstrated. |
| format | Article |
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There are only a few studies dealing with this issue in the elderly, also with controversial results. The aim of this study was the assessment of correlation between genetic markers and the risk of CHD in the elderly. The results indicated DD genotype importance for CHD in the elderly as proven by discriminant analysis (chi2 = 25.77; df = 16; p = 0.0620). However, the use of univariate method demonstrated no correlation between DD genotype of ACE gene polymorphism and coronary artery disease. D allele of ACE gene was associated with higher activities of ACE plasma. A weak, but increased risk of MI is associated with high frequency of DD genotype in the elderly. Strong correlation between ACE polymorphism and ACE plasma activities was demonstrated.</description><identifier>ISSN: 0350-6134</identifier><identifier>PMID: 17598398</identifier><language>eng</language><publisher>Croatia</publisher><subject>Aged ; Coronary Disease - genetics ; Female ; Gene Deletion ; Genes ; Genetics ; Genotype ; Heart disease ; Humans ; Male ; Mortality ; Old age ; Patients ; Peptidyl-Dipeptidase A - genetics ; Polymorphism, Genetic</subject><ispartof>Collegium antropologicum, 2007-03, Vol.31 (1), p.179-183</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17598398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marković, Biserka Bergman</creatorcontrib><creatorcontrib>Bergovec, Mijo</creatorcontrib><creatorcontrib>Reiner, Zeljko</creatorcontrib><creatorcontrib>Sertić, Jadranka</creatorcontrib><creatorcontrib>Vincelj, Josip</creatorcontrib><creatorcontrib>Marković, Maja</creatorcontrib><title>Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease</title><title>Collegium antropologicum</title><addtitle>Coll Antropol</addtitle><description>Controversy exists as to whether the deletion/deletion (DD) genotype of angiotensin l-converting enzyme (ACE) gene polymorphism is associated with coronary heart disease (CHD). There are only a few studies dealing with this issue in the elderly, also with controversial results. The aim of this study was the assessment of correlation between genetic markers and the risk of CHD in the elderly. The results indicated DD genotype importance for CHD in the elderly as proven by discriminant analysis (chi2 = 25.77; df = 16; p = 0.0620). However, the use of univariate method demonstrated no correlation between DD genotype of ACE gene polymorphism and coronary artery disease. D allele of ACE gene was associated with higher activities of ACE plasma. A weak, but increased risk of MI is associated with high frequency of DD genotype in the elderly. Strong correlation between ACE polymorphism and ACE plasma activities was demonstrated.</description><subject>Aged</subject><subject>Coronary Disease - genetics</subject><subject>Female</subject><subject>Gene Deletion</subject><subject>Genes</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Heart disease</subject><subject>Humans</subject><subject>Male</subject><subject>Mortality</subject><subject>Old age</subject><subject>Patients</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Polymorphism, Genetic</subject><issn>0350-6134</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD9PwzAUxD2AaCl8BfQmtkh2nDjOiMq_SpVYYI7c5LkxcuzUdkHh0xOpZWY43XA_nd67C7KkvKSZYLxYkOsYPyktK0HFFVmwqqwlr-WSHB7RYjLewejtNPgw9iYO4DWkHkG5vfEJXTQONlnr3ReGZNwe0P1MA8IeHcKcoe0w2AlGlQy6FOHbpB5aH7xTYYIeVUjQmYgq4g251MpGvD37inw8P72vX7Pt28tm_bDNxrygKUOtNJO8lXkuKpZzzXZ0V1Q6R41cS8a07FgnBNJO17yQchYtVaHqVitVa74i96feMfjDEWNqBhNbtFY59MfYVFSIsmbiX5CLSuTzKTN4dwaPuwG7ZgxmmN9r_tbkv32qcps</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Marković, Biserka Bergman</creator><creator>Bergovec, Mijo</creator><creator>Reiner, Zeljko</creator><creator>Sertić, Jadranka</creator><creator>Vincelj, Josip</creator><creator>Marković, Maja</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8BJ</scope><scope>FQK</scope><scope>JBE</scope><scope>7X8</scope></search><sort><creationdate>200703</creationdate><title>Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease</title><author>Marković, Biserka Bergman ; Bergovec, Mijo ; Reiner, Zeljko ; Sertić, Jadranka ; Vincelj, Josip ; Marković, Maja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p240t-efaf183c82267123f1b0b47f2efe3f811f8d1d66e0df9348834805a4a9cfaa9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Coronary Disease - genetics</topic><topic>Female</topic><topic>Gene Deletion</topic><topic>Genes</topic><topic>Genetics</topic><topic>Genotype</topic><topic>Heart disease</topic><topic>Humans</topic><topic>Male</topic><topic>Mortality</topic><topic>Old age</topic><topic>Patients</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Polymorphism, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marković, Biserka Bergman</creatorcontrib><creatorcontrib>Bergovec, Mijo</creatorcontrib><creatorcontrib>Reiner, Zeljko</creatorcontrib><creatorcontrib>Sertić, Jadranka</creatorcontrib><creatorcontrib>Vincelj, Josip</creatorcontrib><creatorcontrib>Marković, Maja</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>International Bibliography of the Social Sciences (IBSS)</collection><collection>International Bibliography of the Social Sciences</collection><collection>International Bibliography of the Social Sciences</collection><collection>MEDLINE - Academic</collection><jtitle>Collegium antropologicum</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marković, Biserka Bergman</au><au>Bergovec, Mijo</au><au>Reiner, Zeljko</au><au>Sertić, Jadranka</au><au>Vincelj, Josip</au><au>Marković, Maja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease</atitle><jtitle>Collegium antropologicum</jtitle><addtitle>Coll Antropol</addtitle><date>2007-03</date><risdate>2007</risdate><volume>31</volume><issue>1</issue><spage>179</spage><epage>183</epage><pages>179-183</pages><issn>0350-6134</issn><abstract>Controversy exists as to whether the deletion/deletion (DD) genotype of angiotensin l-converting enzyme (ACE) gene polymorphism is associated with coronary heart disease (CHD). 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| ispartof | Collegium antropologicum, 2007-03, Vol.31 (1), p.179-183 |
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| subjects | Aged Coronary Disease - genetics Female Gene Deletion Genes Genetics Genotype Heart disease Humans Male Mortality Old age Patients Peptidyl-Dipeptidase A - genetics Polymorphism, Genetic |
| title | Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease |
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