Impaired angiogenesis in the aging kidney: Vascular endothelial growth factor and Thrombospondin-1 in renal disease

We investigated the relationship of changes in the microvasculature to age-related structural and functional changes in the kidney to determine whether there was evidence of impaired angiogenesis and whether the loss of microvasculature could be accounted for by changes in the local production of an...

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Veröffentlicht in:	American journal of kidney diseases 2001-03, Vol.37 (3), p.601-611
Hauptverfasser:	Kang, Duk-Hee, Anderson, Sharon, Kim, Yoon-Goo, Mazzalli, Marilda, Suga, Shin-ichi, Jefferson, J.Ashley, Gordon, Katherine L., Oyama, Terry T., Hughes, Jeremy, Hugo, Christian, Kerjaschki, Dontsho, Schreiner, George F., Johnson, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - pathology Aging - physiology angiogenesis Animals Biological and medical sciences capillary rarefaction Cell Count Cell Division Endothelial Growth Factors - biosynthesis Endothelium, Vascular - cytology Endothelium, Vascular - physiology Glomerulonephritis Immunoenzyme Techniques Kidney - blood supply Kidney - metabolism Kidney - pathology Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Diseases - physiopathology Kidney Glomerulus - blood supply Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Kidney Tubules - blood supply Kidney Tubules - metabolism Kidney Tubules - pathology Lymphokines - biosynthesis Medical sciences Neovascularization, Physiologic Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Rats Rats, Sprague-Dawley Thrombospondin 1 - biosynthesis thrombospondin-1 (TSP-1) vascular endothelial growth factor (VEGF) Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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