Risk factors of the progression of abdominal aortic calcification in patients on chronic haemodialysis
Background. Vascular calcification is an independent determinant of cardiovascular events in maintenance haemodialysis (HD) patients. It is not known whether acute changes of the serum calcium concentration before and after HD (▵Ca) are associated with the development of aortic calcification. Method...
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| creator | Yamada, Kazuhiro Fujimoto, Shouichi Nishiura, Ryosuke Komatsu, Hiroyuki Tatsumoto, Mariko Sato, Yuji Hara, Seiichiro Hisanaga, Shuichi Ochiai, Hideyuki Nakao, Hiroyuki Eto, Tanenao |
| description | Background. Vascular calcification is an independent determinant of cardiovascular events in maintenance haemodialysis (HD) patients. It is not known whether acute changes of the serum calcium concentration before and after HD (▵Ca) are associated with the development of aortic calcification. Methods. We enrolled 71 patients dialysed with a dialysate with 3.0 mEq/l calcium and determined their aortic calcification index (ACI) by abdominal computed tomography twice at an interval of 3 years. To identify the factors contributing to the rate of progression of aortic calcification, we analysed the average values for clinical and laboratory data obtained between the first and second evaluations of ACI. Results. The second ACI (mean ± SD: 80.2 ± 63.9) was significantly greater than the first ACI (61.0 ± 61.0) after an interval of 35.8 ± 4.2 months. The annualized change of ACI (ΔACI/year) was significantly and directly associated with the ΔCa and C-reactive protein (CRP) (both P < 0.001, P for trend). Stepwise multivariate regression analysis revealed that ΔACI/year was positively and independently associated with CRP, presence of diabetes mellitus and ΔCa, but negatively associated with a premenopausal status in women. Similarly, ΔCa was positively and independently associated with ΔACI/year and the ultrafiltration rate, but was negatively associated with pre-HD Ca. Conclusion. The increase of serum calcium after HD was related to the rate of progression of aortic calcification. Excess calcium is transferred into patients on HD when using a dialysate of 3.0 mEq/l calcium. This may be a risk factor for the development of vascular calcification. |
| doi_str_mv | 10.1093/ndt/gfm031 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70664184</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ndt/gfm031</oup_id><sourcerecordid>1318034991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c551t-61e2d4c084f78d0a71d59b70bef72106339c3ed2a6ec01e50536b08540fd2e7d3</originalsourceid><addsrcrecordid>eNqF0U2LEzEYB_AgiltXL34AGQQ9COM-mUxe5iiLtkJBFAXxEjJ52WZ3JqlJBtxvb0qLBQ96Skh-PCH_P0LPMbzFMJCrYMrVjZuB4AdohXsGbUcEfYhW9RK3QGG4QE9yvgWAoeP8MbrAnAyUMbJC7ovPd41TusSUm-iasrPNPsWbZHP2MRyO1Gji7IOaGhVT8brRatLeea3KQfjQ7OvOhlIHhEbvUgwV7ZSdo_Fqus8-P0WPnJqyfXZaL9G3D--_Xm_a7af1x-t321ZTikvLsO1Mr0H0jgsDimNDh5HDaB3vMDBCBk2s6RSzGrClQAkbQdAenOksN-QSvT7OrV_4udhc5OyzttOkgo1LlhwY67Ho_ws7INAJwSt8-Re8jUuqYVSDRQ2SYlHRmyPSKeacrJP75GeV7iUGeehI1o7ksaOKX5wmLuNszZmeSqng1QmoXKN2SQXt89mJAQPt2dnFZf_vB9uj87nYX3-kSneSccKp3Hz_IbcDWbM12cjP5Deo1rY6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218173518</pqid></control><display><type>article</type><title>Risk factors of the progression of abdominal aortic calcification in patients on chronic haemodialysis</title><source>MEDLINE</source><source>Oxford University Press Journals Current</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Yamada, Kazuhiro ; Fujimoto, Shouichi ; Nishiura, Ryosuke ; Komatsu, Hiroyuki ; Tatsumoto, Mariko ; Sato, Yuji ; Hara, Seiichiro ; Hisanaga, Shuichi ; Ochiai, Hideyuki ; Nakao, Hiroyuki ; Eto, Tanenao</creator><creatorcontrib>Yamada, Kazuhiro ; Fujimoto, Shouichi ; Nishiura, Ryosuke ; Komatsu, Hiroyuki ; Tatsumoto, Mariko ; Sato, Yuji ; Hara, Seiichiro ; Hisanaga, Shuichi ; Ochiai, Hideyuki ; Nakao, Hiroyuki ; Eto, Tanenao</creatorcontrib><description>Background. Vascular calcification is an independent determinant of cardiovascular events in maintenance haemodialysis (HD) patients. It is not known whether acute changes of the serum calcium concentration before and after HD (▵Ca) are associated with the development of aortic calcification. Methods. We enrolled 71 patients dialysed with a dialysate with 3.0 mEq/l calcium and determined their aortic calcification index (ACI) by abdominal computed tomography twice at an interval of 3 years. To identify the factors contributing to the rate of progression of aortic calcification, we analysed the average values for clinical and laboratory data obtained between the first and second evaluations of ACI. Results. The second ACI (mean ± SD: 80.2 ± 63.9) was significantly greater than the first ACI (61.0 ± 61.0) after an interval of 35.8 ± 4.2 months. The annualized change of ACI (ΔACI/year) was significantly and directly associated with the ΔCa and C-reactive protein (CRP) (both P < 0.001, P for trend). Stepwise multivariate regression analysis revealed that ΔACI/year was positively and independently associated with CRP, presence of diabetes mellitus and ΔCa, but negatively associated with a premenopausal status in women. Similarly, ΔCa was positively and independently associated with ΔACI/year and the ultrafiltration rate, but was negatively associated with pre-HD Ca. Conclusion. The increase of serum calcium after HD was related to the rate of progression of aortic calcification. Excess calcium is transferred into patients on HD when using a dialysate of 3.0 mEq/l calcium. This may be a risk factor for the development of vascular calcification.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfm031</identifier><identifier>PMID: 17395663</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Aorta, Abdominal - diagnostic imaging ; aortic calcification ; Aortic Diseases - diagnostic imaging ; Biological and medical sciences ; C-reactive protein ; C-Reactive Protein - metabolism ; Calcinosis - diagnostic imaging ; calcium ; Calcium - administration & dosage ; Calcium - blood ; Diabetes Complications ; dialysate ; Dialysis Solutions - chemistry ; Disease Progression ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Glomerulonephritis ; haemodialysis ; Humans ; Intensive care medicine ; Kidney Diseases - blood ; Kidney Diseases - complications ; Kidney Diseases - therapy ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Osmolar Concentration ; premenopausal women ; Premenopause ; Renal Dialysis - adverse effects ; Renal failure ; Risk Factors ; Tomography, X-Ray Computed</subject><ispartof>Nephrology, dialysis, transplantation, 2007-07, Vol.22 (7), p.2032-2037</ispartof><rights>The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2007</rights><rights>2007 INIST-CNRS</rights><rights>The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-61e2d4c084f78d0a71d59b70bef72106339c3ed2a6ec01e50536b08540fd2e7d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18910546$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17395663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, Kazuhiro</creatorcontrib><creatorcontrib>Fujimoto, Shouichi</creatorcontrib><creatorcontrib>Nishiura, Ryosuke</creatorcontrib><creatorcontrib>Komatsu, Hiroyuki</creatorcontrib><creatorcontrib>Tatsumoto, Mariko</creatorcontrib><creatorcontrib>Sato, Yuji</creatorcontrib><creatorcontrib>Hara, Seiichiro</creatorcontrib><creatorcontrib>Hisanaga, Shuichi</creatorcontrib><creatorcontrib>Ochiai, Hideyuki</creatorcontrib><creatorcontrib>Nakao, Hiroyuki</creatorcontrib><creatorcontrib>Eto, Tanenao</creatorcontrib><title>Risk factors of the progression of abdominal aortic calcification in patients on chronic haemodialysis</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>Background. Vascular calcification is an independent determinant of cardiovascular events in maintenance haemodialysis (HD) patients. It is not known whether acute changes of the serum calcium concentration before and after HD (▵Ca) are associated with the development of aortic calcification. Methods. We enrolled 71 patients dialysed with a dialysate with 3.0 mEq/l calcium and determined their aortic calcification index (ACI) by abdominal computed tomography twice at an interval of 3 years. To identify the factors contributing to the rate of progression of aortic calcification, we analysed the average values for clinical and laboratory data obtained between the first and second evaluations of ACI. Results. The second ACI (mean ± SD: 80.2 ± 63.9) was significantly greater than the first ACI (61.0 ± 61.0) after an interval of 35.8 ± 4.2 months. The annualized change of ACI (ΔACI/year) was significantly and directly associated with the ΔCa and C-reactive protein (CRP) (both P < 0.001, P for trend). Stepwise multivariate regression analysis revealed that ΔACI/year was positively and independently associated with CRP, presence of diabetes mellitus and ΔCa, but negatively associated with a premenopausal status in women. Similarly, ΔCa was positively and independently associated with ΔACI/year and the ultrafiltration rate, but was negatively associated with pre-HD Ca. Conclusion. The increase of serum calcium after HD was related to the rate of progression of aortic calcification. Excess calcium is transferred into patients on HD when using a dialysate of 3.0 mEq/l calcium. This may be a risk factor for the development of vascular calcification.</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Aorta, Abdominal - diagnostic imaging</subject><subject>aortic calcification</subject><subject>Aortic Diseases - diagnostic imaging</subject><subject>Biological and medical sciences</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Calcinosis - diagnostic imaging</subject><subject>calcium</subject><subject>Calcium - administration & dosage</subject><subject>Calcium - blood</subject><subject>Diabetes Complications</subject><subject>dialysate</subject><subject>Dialysis Solutions - chemistry</subject><subject>Disease Progression</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Glomerulonephritis</subject><subject>haemodialysis</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney Diseases - blood</subject><subject>Kidney Diseases - complications</subject><subject>Kidney Diseases - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Osmolar Concentration</subject><subject>premenopausal women</subject><subject>Premenopause</subject><subject>Renal Dialysis - adverse effects</subject><subject>Renal failure</subject><subject>Risk Factors</subject><subject>Tomography, X-Ray Computed</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U2LEzEYB_AgiltXL34AGQQ9COM-mUxe5iiLtkJBFAXxEjJ52WZ3JqlJBtxvb0qLBQ96Skh-PCH_P0LPMbzFMJCrYMrVjZuB4AdohXsGbUcEfYhW9RK3QGG4QE9yvgWAoeP8MbrAnAyUMbJC7ovPd41TusSUm-iasrPNPsWbZHP2MRyO1Gji7IOaGhVT8brRatLeea3KQfjQ7OvOhlIHhEbvUgwV7ZSdo_Fqus8-P0WPnJqyfXZaL9G3D--_Xm_a7af1x-t321ZTikvLsO1Mr0H0jgsDimNDh5HDaB3vMDBCBk2s6RSzGrClQAkbQdAenOksN-QSvT7OrV_4udhc5OyzttOkgo1LlhwY67Ho_ws7INAJwSt8-Re8jUuqYVSDRQ2SYlHRmyPSKeacrJP75GeV7iUGeehI1o7ksaOKX5wmLuNszZmeSqng1QmoXKN2SQXt89mJAQPt2dnFZf_vB9uj87nYX3-kSneSccKp3Hz_IbcDWbM12cjP5Deo1rY6</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Yamada, Kazuhiro</creator><creator>Fujimoto, Shouichi</creator><creator>Nishiura, Ryosuke</creator><creator>Komatsu, Hiroyuki</creator><creator>Tatsumoto, Mariko</creator><creator>Sato, Yuji</creator><creator>Hara, Seiichiro</creator><creator>Hisanaga, Shuichi</creator><creator>Ochiai, Hideyuki</creator><creator>Nakao, Hiroyuki</creator><creator>Eto, Tanenao</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20070701</creationdate><title>Risk factors of the progression of abdominal aortic calcification in patients on chronic haemodialysis</title><author>Yamada, Kazuhiro ; Fujimoto, Shouichi ; Nishiura, Ryosuke ; Komatsu, Hiroyuki ; Tatsumoto, Mariko ; Sato, Yuji ; Hara, Seiichiro ; Hisanaga, Shuichi ; Ochiai, Hideyuki ; Nakao, Hiroyuki ; Eto, Tanenao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-61e2d4c084f78d0a71d59b70bef72106339c3ed2a6ec01e50536b08540fd2e7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Aorta, Abdominal - diagnostic imaging</topic><topic>aortic calcification</topic><topic>Aortic Diseases - diagnostic imaging</topic><topic>Biological and medical sciences</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Calcinosis - diagnostic imaging</topic><topic>calcium</topic><topic>Calcium - administration & dosage</topic><topic>Calcium - blood</topic><topic>Diabetes Complications</topic><topic>dialysate</topic><topic>Dialysis Solutions - chemistry</topic><topic>Disease Progression</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Glomerulonephritis</topic><topic>haemodialysis</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney Diseases - blood</topic><topic>Kidney Diseases - complications</topic><topic>Kidney Diseases - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Osmolar Concentration</topic><topic>premenopausal women</topic><topic>Premenopause</topic><topic>Renal Dialysis - adverse effects</topic><topic>Renal failure</topic><topic>Risk Factors</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, Kazuhiro</creatorcontrib><creatorcontrib>Fujimoto, Shouichi</creatorcontrib><creatorcontrib>Nishiura, Ryosuke</creatorcontrib><creatorcontrib>Komatsu, Hiroyuki</creatorcontrib><creatorcontrib>Tatsumoto, Mariko</creatorcontrib><creatorcontrib>Sato, Yuji</creatorcontrib><creatorcontrib>Hara, Seiichiro</creatorcontrib><creatorcontrib>Hisanaga, Shuichi</creatorcontrib><creatorcontrib>Ochiai, Hideyuki</creatorcontrib><creatorcontrib>Nakao, Hiroyuki</creatorcontrib><creatorcontrib>Eto, Tanenao</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, Kazuhiro</au><au>Fujimoto, Shouichi</au><au>Nishiura, Ryosuke</au><au>Komatsu, Hiroyuki</au><au>Tatsumoto, Mariko</au><au>Sato, Yuji</au><au>Hara, Seiichiro</au><au>Hisanaga, Shuichi</au><au>Ochiai, Hideyuki</au><au>Nakao, Hiroyuki</au><au>Eto, Tanenao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors of the progression of abdominal aortic calcification in patients on chronic haemodialysis</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>22</volume><issue>7</issue><spage>2032</spage><epage>2037</epage><pages>2032-2037</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Background. Vascular calcification is an independent determinant of cardiovascular events in maintenance haemodialysis (HD) patients. It is not known whether acute changes of the serum calcium concentration before and after HD (▵Ca) are associated with the development of aortic calcification. Methods. We enrolled 71 patients dialysed with a dialysate with 3.0 mEq/l calcium and determined their aortic calcification index (ACI) by abdominal computed tomography twice at an interval of 3 years. To identify the factors contributing to the rate of progression of aortic calcification, we analysed the average values for clinical and laboratory data obtained between the first and second evaluations of ACI. Results. The second ACI (mean ± SD: 80.2 ± 63.9) was significantly greater than the first ACI (61.0 ± 61.0) after an interval of 35.8 ± 4.2 months. The annualized change of ACI (ΔACI/year) was significantly and directly associated with the ΔCa and C-reactive protein (CRP) (both P < 0.001, P for trend). Stepwise multivariate regression analysis revealed that ΔACI/year was positively and independently associated with CRP, presence of diabetes mellitus and ΔCa, but negatively associated with a premenopausal status in women. Similarly, ΔCa was positively and independently associated with ΔACI/year and the ultrafiltration rate, but was negatively associated with pre-HD Ca. Conclusion. The increase of serum calcium after HD was related to the rate of progression of aortic calcification. Excess calcium is transferred into patients on HD when using a dialysate of 3.0 mEq/l calcium. This may be a risk factor for the development of vascular calcification.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>17395663</pmid><doi>10.1093/ndt/gfm031</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals Current; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Aorta, Abdominal - diagnostic imaging aortic calcification Aortic Diseases - diagnostic imaging Biological and medical sciences C-reactive protein C-Reactive Protein - metabolism Calcinosis - diagnostic imaging calcium Calcium - administration & dosage Calcium - blood Diabetes Complications dialysate Dialysis Solutions - chemistry Disease Progression Emergency and intensive care: renal failure. Dialysis management Female Glomerulonephritis haemodialysis Humans Intensive care medicine Kidney Diseases - blood Kidney Diseases - complications Kidney Diseases - therapy Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Osmolar Concentration premenopausal women Premenopause Renal Dialysis - adverse effects Renal failure Risk Factors Tomography, X-Ray Computed |
| title | Risk factors of the progression of abdominal aortic calcification in patients on chronic haemodialysis |
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