Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABA(A) receptor-mediated mechanism

Transient changes in the activity of midbrain dopamine neurons encode an error signal that contributes to associative learning. Although considerable attention has been devoted to the mechanisms contributing to phasic increases in dopamine activity, less is known about the origin of the transient ce...

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Veröffentlicht in:	The Journal of neuroscience 2007-06, Vol.27 (26), p.6923-6930
Hauptverfasser:	Ji, Huifang, Shepard, Paul D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dopamine - metabolism Electric Stimulation GABA Antagonists - pharmacology gamma-Aminobutyric Acid - metabolism Habenula - anatomy & histology Habenula - metabolism Male Mesencephalon - anatomy & histology Mesencephalon - metabolism Neural Inhibition - physiology Neural Pathways - anatomy & histology Neural Pathways - metabolism Neurons - physiology Potassium Channel Blockers - pharmacology Rats Rats, Sprague-Dawley Receptors, GABA-A - metabolism Reward Substantia Nigra - anatomy & histology Substantia Nigra - metabolism Synaptic Transmission - physiology Ventral Tegmental Area - anatomy & histology Ventral Tegmental Area - metabolism
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