Cellular Mechanisms for Insulin Resistance in Normal Pregnancy and Gestational Diabetes

Infusion of TNF-α results in increased insulin resistance in rat and human skeletal muscle cells incubated in culture (21), although TNF-α neutralization over a period of 4 weeks had no effect on insulin sensitivity in obese type 2 diabetic subjects (22). The role of excess lipid turnover and cytoki...

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Veröffentlicht in:	Diabetes care 2007-07, Vol.30 (Supplement_2), p.S112-S119
Hauptverfasser:	Barbour, Linda A, McCurdy, Carrie E, Hernandez, Teri L, Kirwan, John P, Catalano, Patrick M, Friedman, Jacob E
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Diabetes Diabetes, Gestational - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Glucose - metabolism Hormones - secretion Humans Hyperglycemia Insulin Insulin Resistance Medical sciences Metabolic diseases Miscellaneous Muscle, Skeletal - metabolism Placenta - physiology Pregnancy Pregnancy - physiology Proteins Public health. Hygiene Public health. Hygiene-occupational medicine Reference Values Rodents Womens health
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