Cellular Mechanisms for Insulin Resistance in Normal Pregnancy and Gestational Diabetes
Infusion of TNF-α results in increased insulin resistance in rat and human skeletal muscle cells incubated in culture (21), although TNF-α neutralization over a period of 4 weeks had no effect on insulin sensitivity in obese type 2 diabetic subjects (22). The role of excess lipid turnover and cytoki...
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| Veröffentlicht in: | Diabetes care 2007-07, Vol.30 (Supplement_2), p.S112-S119 |
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| container_end_page | S119 |
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| container_issue | Supplement_2 |
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| container_title | Diabetes care |
| container_volume | 30 |
| creator | Barbour, Linda A McCurdy, Carrie E Hernandez, Teri L Kirwan, John P Catalano, Patrick M Friedman, Jacob E |
| description | Infusion of TNF-α results in increased insulin resistance in rat and human skeletal muscle cells incubated in culture (21), although TNF-α neutralization over a period of 4 weeks had no effect on insulin sensitivity in obese type 2 diabetic subjects (22). The role of excess lipid turnover and cytokine production from adipose tissue, especially in obese patients, could potentially be very important in the overall insulin resistance and excess substrate supply that drives maternal-fetal energy transfer and increased neonatal adiposity. |
| doi_str_mv | 10.2337/dc07-s202 |
| format | Article |
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The role of excess lipid turnover and cytokine production from adipose tissue, especially in obese patients, could potentially be very important in the overall insulin resistance and excess substrate supply that drives maternal-fetal energy transfer and increased neonatal adiposity.</description><subject>Biological and medical sciences</subject><subject>Diabetes</subject><subject>Diabetes, Gestational - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. 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| ispartof | Diabetes care, 2007-07, Vol.30 (Supplement_2), p.S112-S119 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences Diabetes Diabetes, Gestational - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Glucose - metabolism Hormones - secretion Humans Hyperglycemia Insulin Insulin Resistance Medical sciences Metabolic diseases Miscellaneous Muscle, Skeletal - metabolism Placenta - physiology Pregnancy Pregnancy - physiology Proteins Public health. Hygiene Public health. Hygiene-occupational medicine Reference Values Rodents Womens health |
| title | Cellular Mechanisms for Insulin Resistance in Normal Pregnancy and Gestational Diabetes |
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