Low normal TSH levels are associated with low bone mineral density in healthy postmenopausal women
Summary Objective Hyperthyroidism is accompanied by low bone mass. Because the reference range of TSH levels is defined statistically, some individuals with low normal TSH levels may have mild hyperthyroidism and reduced bone mass. We therefore determined whether serum TSH levels correlate with bon...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2006-01, Vol.64 (1), p.86-90 |
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| creator | Kim, Duk Jae Khang, Young Ho Koh, Jung-Min Shong, Young Kee Kim, Ghi Su |
| description | Summary
Objective Hyperthyroidism is accompanied by low bone mass. Because the reference range of TSH levels is defined statistically, some individuals with low normal TSH levels may have mild hyperthyroidism and reduced bone mass. We therefore determined whether serum TSH levels correlate with bone mineral density (BMD).
Design A cross‐sectional hospital‐based survey.
Participants Nine hundred and fifty‐nine healthy postmenopausal women.
Measurements We measured BMD at the lumbar spine and femoral neck using dual energy X‐ray absorptiometry, and serum TSH concentrations using immunoluminometry.
Results BMD at the lumbar spine and femoral neck increased with TSH level (P for trend < 0·001 at both sites). Even after adjustment for age, years since menopause and body mass index, subjects with low normal TSH levels (0·5–1·1 mU/l) had significantly lower BMDs at the lumbar spine (0·863 ± 0·009 g/cm2vs 0·900 ± 0·009 g/cm2, P = 0·004) and femoral neck (0·660 ± 0·006 g/cm2vs 0·683 ± 0·006 g/cm2, P = 0·006) than those with high normal TSH levels (2·8–5·0 mU/l), as well as a 2·2‐fold increased risk of osteoporosis (95% confidence interval: 1·2–4·0).
Conclusion These results suggest that low normal TSH levels may not be physiological for postmenopausal women and, during treatment of hypothyroidism, may not be adequate for avoiding osteoporosis. |
| doi_str_mv | 10.1111/j.1365-2265.2005.02422.x |
| format | Article |
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Objective Hyperthyroidism is accompanied by low bone mass. Because the reference range of TSH levels is defined statistically, some individuals with low normal TSH levels may have mild hyperthyroidism and reduced bone mass. We therefore determined whether serum TSH levels correlate with bone mineral density (BMD).
Design A cross‐sectional hospital‐based survey.
Participants Nine hundred and fifty‐nine healthy postmenopausal women.
Measurements We measured BMD at the lumbar spine and femoral neck using dual energy X‐ray absorptiometry, and serum TSH concentrations using immunoluminometry.
Results BMD at the lumbar spine and femoral neck increased with TSH level (P for trend < 0·001 at both sites). Even after adjustment for age, years since menopause and body mass index, subjects with low normal TSH levels (0·5–1·1 mU/l) had significantly lower BMDs at the lumbar spine (0·863 ± 0·009 g/cm2vs 0·900 ± 0·009 g/cm2, P = 0·004) and femoral neck (0·660 ± 0·006 g/cm2vs 0·683 ± 0·006 g/cm2, P = 0·006) than those with high normal TSH levels (2·8–5·0 mU/l), as well as a 2·2‐fold increased risk of osteoporosis (95% confidence interval: 1·2–4·0).
Conclusion These results suggest that low normal TSH levels may not be physiological for postmenopausal women and, during treatment of hypothyroidism, may not be adequate for avoiding osteoporosis.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2005.02422.x</identifier><identifier>PMID: 16402934</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Aged ; Biological and medical sciences ; Body Mass Index ; Bone Density ; Cross-Sectional Studies ; Endocrinopathies ; Female ; Femur Neck - physiopathology ; Fundamental and applied biological sciences. Psychology ; Humans ; Lumbar Vertebrae - physiopathology ; Medical sciences ; Middle Aged ; Postmenopause - blood ; Reference Values ; Regression Analysis ; Testosterone - blood ; Thyrotropin - blood ; Time Factors ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2006-01, Vol.64 (1), p.86-90</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Jan 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4622-beb1d2078417082fdd69b8618bb7442c586a3eced39384b4d85c2681f9c41ab13</citedby><cites>FETCH-LOGICAL-c4622-beb1d2078417082fdd69b8618bb7442c586a3eced39384b4d85c2681f9c41ab13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2005.02422.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2005.02422.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17474693$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16402934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Duk Jae</creatorcontrib><creatorcontrib>Khang, Young Ho</creatorcontrib><creatorcontrib>Koh, Jung-Min</creatorcontrib><creatorcontrib>Shong, Young Kee</creatorcontrib><creatorcontrib>Kim, Ghi Su</creatorcontrib><title>Low normal TSH levels are associated with low bone mineral density in healthy postmenopausal women</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Objective Hyperthyroidism is accompanied by low bone mass. Because the reference range of TSH levels is defined statistically, some individuals with low normal TSH levels may have mild hyperthyroidism and reduced bone mass. We therefore determined whether serum TSH levels correlate with bone mineral density (BMD).
Design A cross‐sectional hospital‐based survey.
Participants Nine hundred and fifty‐nine healthy postmenopausal women.
Measurements We measured BMD at the lumbar spine and femoral neck using dual energy X‐ray absorptiometry, and serum TSH concentrations using immunoluminometry.
Results BMD at the lumbar spine and femoral neck increased with TSH level (P for trend < 0·001 at both sites). Even after adjustment for age, years since menopause and body mass index, subjects with low normal TSH levels (0·5–1·1 mU/l) had significantly lower BMDs at the lumbar spine (0·863 ± 0·009 g/cm2vs 0·900 ± 0·009 g/cm2, P = 0·004) and femoral neck (0·660 ± 0·006 g/cm2vs 0·683 ± 0·006 g/cm2, P = 0·006) than those with high normal TSH levels (2·8–5·0 mU/l), as well as a 2·2‐fold increased risk of osteoporosis (95% confidence interval: 1·2–4·0).
Conclusion These results suggest that low normal TSH levels may not be physiological for postmenopausal women and, during treatment of hypothyroidism, may not be adequate for avoiding osteoporosis.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Bone Density</subject><subject>Cross-Sectional Studies</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Femur Neck - physiopathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Lumbar Vertebrae - physiopathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postmenopause - blood</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Testosterone - blood</subject><subject>Thyrotropin - blood</subject><subject>Time Factors</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV2LEzEYhYMobl39CxIEvZsxX5PJXHghZd0KpQq74mVIMhmampnUZGbb_nsztuyCV-YmeclzDi_nAAAxKnE-H3clprwqCOFVSRCqSkQYIeXxGVg8fjwHC0QRKhDn7Aq8SmmHMilQ_RJcYc4QaShbAL0OBziE2CsP7-9W0NsH6xNU0UKVUjBOjbaFBzduoc-kDoOFvRtszHxrh-TGE3QD3Frlx-0J7kMaezuEvZpSJg4hD6_Bi075ZN9c7mvw48vN_XJVrL_dfl1-XheGcUIKbTVuCaoFwzUSpGtb3mjBsdC6ZoyYSnBFrbEtbahgmrWiMoQL3DWGYaUxvQYfzr77GH5PNo2yd8lY79Vgw5RknZOgFa4y-O4fcBemOOTdJG6EoJzy2U2cIRNDStF2ch9dr-JJYiTnEuROzlnLOWs5lyD_liCPWfr24j_p3rZPwkvqGXh_AVQyyndRDcalJ65mNeMNzdynM3dw3p7-ewG5vNnMr6wvznqXRnt81Kv4S_Ka1pX8ubmVVcPuOP6-khv6Bzy-sNQ</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Kim, Duk Jae</creator><creator>Khang, Young Ho</creator><creator>Koh, Jung-Min</creator><creator>Shong, Young Kee</creator><creator>Kim, Ghi Su</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>Low normal TSH levels are associated with low bone mineral density in healthy postmenopausal women</title><author>Kim, Duk Jae ; Khang, Young Ho ; Koh, Jung-Min ; Shong, Young Kee ; Kim, Ghi Su</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4622-beb1d2078417082fdd69b8618bb7442c586a3eced39384b4d85c2681f9c41ab13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Bone Density</topic><topic>Cross-Sectional Studies</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Femur Neck - physiopathology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Lumbar Vertebrae - physiopathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Postmenopause - blood</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>Testosterone - blood</topic><topic>Thyrotropin - blood</topic><topic>Time Factors</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Duk Jae</creatorcontrib><creatorcontrib>Khang, Young Ho</creatorcontrib><creatorcontrib>Koh, Jung-Min</creatorcontrib><creatorcontrib>Shong, Young Kee</creatorcontrib><creatorcontrib>Kim, Ghi Su</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Duk Jae</au><au>Khang, Young Ho</au><au>Koh, Jung-Min</au><au>Shong, Young Kee</au><au>Kim, Ghi Su</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low normal TSH levels are associated with low bone mineral density in healthy postmenopausal women</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2006-01</date><risdate>2006</risdate><volume>64</volume><issue>1</issue><spage>86</spage><epage>90</epage><pages>86-90</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective Hyperthyroidism is accompanied by low bone mass. Because the reference range of TSH levels is defined statistically, some individuals with low normal TSH levels may have mild hyperthyroidism and reduced bone mass. We therefore determined whether serum TSH levels correlate with bone mineral density (BMD).
Design A cross‐sectional hospital‐based survey.
Participants Nine hundred and fifty‐nine healthy postmenopausal women.
Measurements We measured BMD at the lumbar spine and femoral neck using dual energy X‐ray absorptiometry, and serum TSH concentrations using immunoluminometry.
Results BMD at the lumbar spine and femoral neck increased with TSH level (P for trend < 0·001 at both sites). Even after adjustment for age, years since menopause and body mass index, subjects with low normal TSH levels (0·5–1·1 mU/l) had significantly lower BMDs at the lumbar spine (0·863 ± 0·009 g/cm2vs 0·900 ± 0·009 g/cm2, P = 0·004) and femoral neck (0·660 ± 0·006 g/cm2vs 0·683 ± 0·006 g/cm2, P = 0·006) than those with high normal TSH levels (2·8–5·0 mU/l), as well as a 2·2‐fold increased risk of osteoporosis (95% confidence interval: 1·2–4·0).
Conclusion These results suggest that low normal TSH levels may not be physiological for postmenopausal women and, during treatment of hypothyroidism, may not be adequate for avoiding osteoporosis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16402934</pmid><doi>10.1111/j.1365-2265.2005.02422.x</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Biological and medical sciences Body Mass Index Bone Density Cross-Sectional Studies Endocrinopathies Female Femur Neck - physiopathology Fundamental and applied biological sciences. Psychology Humans Lumbar Vertebrae - physiopathology Medical sciences Middle Aged Postmenopause - blood Reference Values Regression Analysis Testosterone - blood Thyrotropin - blood Time Factors Vertebrates: endocrinology |
| title | Low normal TSH levels are associated with low bone mineral density in healthy postmenopausal women |
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