Lactate contents from cerebrospinal fluid in experimental subarachnoid hemorrhage, well correlate with vasospasm: ongoing and neurologic status
The role of lactate composition of cerebrospinal fluid (CSF) with vasospasm severity and rabbit neurologic status in subarachnoid hemorrhage was determined. The neurologic status of 20 New Zealand rabbits were graded initially and then, anesthetized and basal angiograms were performed. Then 1.0 mL o...
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| Veröffentlicht in: | Journal of neurosurgical anesthesiology 2007-07, Vol.19 (3), p.166-170 |
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| creator | Cengiz, Sahika Liva Ak, Ahmet Ustün, Mehmet Erkan Karaköse, Serdar |
| description | The role of lactate composition of cerebrospinal fluid (CSF) with vasospasm severity and rabbit neurologic status in subarachnoid hemorrhage was determined. The neurologic status of 20 New Zealand rabbits were graded initially and then, anesthetized and basal angiograms were performed. Then 1.0 mL of CSF was withdrawn through cisterna magna and then 1 mL autologous arterial blood was injected in all rabbits over 1 minute. After 5 days, neurologic severity score (NSS) and vertebrobasilar angiograms of all rabbits were repeated. Rabbits without radiologic vasospasm or spasm under 50% (n=7) were termed as group 1. Rabbits whose cerebral vasospasm were 50% or over 50% (n=7) and NSS is lesser than 3 were termed as groups 2, and rabbits whose cerebral vasospasm were 50% or above 50% (n=7) and NSS is greater than 3 were termed groups 3. On day 7, the CSF lactate values of each group were significantly different (P |
| doi_str_mv | 10.1097/ANA.0b013e3180461278 |
| format | Article |
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The neurologic status of 20 New Zealand rabbits were graded initially and then, anesthetized and basal angiograms were performed. Then 1.0 mL of CSF was withdrawn through cisterna magna and then 1 mL autologous arterial blood was injected in all rabbits over 1 minute. After 5 days, neurologic severity score (NSS) and vertebrobasilar angiograms of all rabbits were repeated. Rabbits without radiologic vasospasm or spasm under 50% (n=7) were termed as group 1. Rabbits whose cerebral vasospasm were 50% or over 50% (n=7) and NSS is lesser than 3 were termed as groups 2, and rabbits whose cerebral vasospasm were 50% or above 50% (n=7) and NSS is greater than 3 were termed groups 3. On day 7, the CSF lactate values of each group were significantly different (P<0.05) with each other. But when compared with only CSF baseline lactate values groups 2 and 3 were significantly different (P<0.05). However, the NSSs were similar in groups 1 and 2, but group 3 significantly differed from groups 1 and 2 (P<0.05). All groups significantly differed from baseline NSSs (P<0.05). The data showed clearly that the degree of vasospasm correlates not only with neurologic status but also with CSF lactate levels. We suggest that CSF lactate level may be useful as a surrogate marker of cerebral vasospasm degree after subarachnoid hemorrhage in clinics where invasive cerebral angiography could not be assessed for whatever reasons.</description><identifier>ISSN: 0898-4921</identifier><identifier>DOI: 10.1097/ANA.0b013e3180461278</identifier><identifier>PMID: 17592347</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Basilar Artery - diagnostic imaging ; Biomarkers - cerebrospinal fluid ; Cisterna Magna ; Disease Models, Animal ; Lactic Acid - cerebrospinal fluid ; Male ; Nervous System Diseases - cerebrospinal fluid ; Rabbits ; Radiography ; Severity of Illness Index ; Subarachnoid Hemorrhage - cerebrospinal fluid ; Subarachnoid Hemorrhage - complications ; Vasospasm, Intracranial - complications ; Vasospasm, Intracranial - diagnosis ; Vertebral Artery - diagnostic imaging</subject><ispartof>Journal of neurosurgical anesthesiology, 2007-07, Vol.19 (3), p.166-170</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c254t-9e6a5e146f6b6c45bdb8463eeacc64e28a0f3dd68e6dfe4c0ab6dcef3e50752f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17592347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cengiz, Sahika Liva</creatorcontrib><creatorcontrib>Ak, Ahmet</creatorcontrib><creatorcontrib>Ustün, Mehmet Erkan</creatorcontrib><creatorcontrib>Karaköse, Serdar</creatorcontrib><title>Lactate contents from cerebrospinal fluid in experimental subarachnoid hemorrhage, well correlate with vasospasm: ongoing and neurologic status</title><title>Journal of neurosurgical anesthesiology</title><addtitle>J Neurosurg Anesthesiol</addtitle><description>The role of lactate composition of cerebrospinal fluid (CSF) with vasospasm severity and rabbit neurologic status in subarachnoid hemorrhage was determined. The neurologic status of 20 New Zealand rabbits were graded initially and then, anesthetized and basal angiograms were performed. Then 1.0 mL of CSF was withdrawn through cisterna magna and then 1 mL autologous arterial blood was injected in all rabbits over 1 minute. After 5 days, neurologic severity score (NSS) and vertebrobasilar angiograms of all rabbits were repeated. Rabbits without radiologic vasospasm or spasm under 50% (n=7) were termed as group 1. Rabbits whose cerebral vasospasm were 50% or over 50% (n=7) and NSS is lesser than 3 were termed as groups 2, and rabbits whose cerebral vasospasm were 50% or above 50% (n=7) and NSS is greater than 3 were termed groups 3. On day 7, the CSF lactate values of each group were significantly different (P<0.05) with each other. But when compared with only CSF baseline lactate values groups 2 and 3 were significantly different (P<0.05). However, the NSSs were similar in groups 1 and 2, but group 3 significantly differed from groups 1 and 2 (P<0.05). All groups significantly differed from baseline NSSs (P<0.05). The data showed clearly that the degree of vasospasm correlates not only with neurologic status but also with CSF lactate levels. We suggest that CSF lactate level may be useful as a surrogate marker of cerebral vasospasm degree after subarachnoid hemorrhage in clinics where invasive cerebral angiography could not be assessed for whatever reasons.</description><subject>Animals</subject><subject>Basilar Artery - diagnostic imaging</subject><subject>Biomarkers - cerebrospinal fluid</subject><subject>Cisterna Magna</subject><subject>Disease Models, Animal</subject><subject>Lactic Acid - cerebrospinal fluid</subject><subject>Male</subject><subject>Nervous System Diseases - cerebrospinal fluid</subject><subject>Rabbits</subject><subject>Radiography</subject><subject>Severity of Illness Index</subject><subject>Subarachnoid Hemorrhage - cerebrospinal fluid</subject><subject>Subarachnoid Hemorrhage - complications</subject><subject>Vasospasm, Intracranial - complications</subject><subject>Vasospasm, Intracranial - diagnosis</subject><subject>Vertebral Artery - diagnostic imaging</subject><issn>0898-4921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMtOwzAQRb0A0VL4A4S8YkWKHTtOwq6qeEkVbGAdOc44CUrsYCcUvoJfxlUrIbEaaebeo9FB6IKSJSV5erN6Xi1JSSgDRjPCBY3T7AjNSZZnEc9jOkOn3r8TQvI4SU_QjKZJHjOeztHPRqpRjoCVNSOY0WPtbI8VOCid9UNrZId1N7UVbg2GrwFc24dc2PqplE6qxthwbKC3zjWyhmu8ha4LPOeg25G37djgT-kDTfr-FltT29bUWJoKG5ic7WzdKuzDG5M_Q8dadh7OD3OB3u7vXteP0ebl4Wm92kQqTvgY5SBkApQLLUqheFJWZcYFA5BKCQ5xJolmVSUyEJUGrogsRaVAM0hImsSaLdDVnjs4-zGBH4u-9So8Lg3YyRcpEYJxloQg3wdV0OEd6GIIBqT7LigpdvKLIL_4Lz_ULg_8qeyh-isdzLNfLteIRg</recordid><startdate>200707</startdate><enddate>200707</enddate><creator>Cengiz, Sahika Liva</creator><creator>Ak, Ahmet</creator><creator>Ustün, Mehmet Erkan</creator><creator>Karaköse, Serdar</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200707</creationdate><title>Lactate contents from cerebrospinal fluid in experimental subarachnoid hemorrhage, well correlate with vasospasm: ongoing and neurologic status</title><author>Cengiz, Sahika Liva ; Ak, Ahmet ; Ustün, Mehmet Erkan ; Karaköse, Serdar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c254t-9e6a5e146f6b6c45bdb8463eeacc64e28a0f3dd68e6dfe4c0ab6dcef3e50752f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Basilar Artery - diagnostic imaging</topic><topic>Biomarkers - cerebrospinal fluid</topic><topic>Cisterna Magna</topic><topic>Disease Models, Animal</topic><topic>Lactic Acid - cerebrospinal fluid</topic><topic>Male</topic><topic>Nervous System Diseases - cerebrospinal fluid</topic><topic>Rabbits</topic><topic>Radiography</topic><topic>Severity of Illness Index</topic><topic>Subarachnoid Hemorrhage - cerebrospinal fluid</topic><topic>Subarachnoid Hemorrhage - complications</topic><topic>Vasospasm, Intracranial - complications</topic><topic>Vasospasm, Intracranial - diagnosis</topic><topic>Vertebral Artery - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cengiz, Sahika Liva</creatorcontrib><creatorcontrib>Ak, Ahmet</creatorcontrib><creatorcontrib>Ustün, Mehmet Erkan</creatorcontrib><creatorcontrib>Karaköse, Serdar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurosurgical anesthesiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cengiz, Sahika Liva</au><au>Ak, Ahmet</au><au>Ustün, Mehmet Erkan</au><au>Karaköse, Serdar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactate contents from cerebrospinal fluid in experimental subarachnoid hemorrhage, well correlate with vasospasm: ongoing and neurologic status</atitle><jtitle>Journal of neurosurgical anesthesiology</jtitle><addtitle>J Neurosurg Anesthesiol</addtitle><date>2007-07</date><risdate>2007</risdate><volume>19</volume><issue>3</issue><spage>166</spage><epage>170</epage><pages>166-170</pages><issn>0898-4921</issn><abstract>The role of lactate composition of cerebrospinal fluid (CSF) with vasospasm severity and rabbit neurologic status in subarachnoid hemorrhage was determined. The neurologic status of 20 New Zealand rabbits were graded initially and then, anesthetized and basal angiograms were performed. Then 1.0 mL of CSF was withdrawn through cisterna magna and then 1 mL autologous arterial blood was injected in all rabbits over 1 minute. After 5 days, neurologic severity score (NSS) and vertebrobasilar angiograms of all rabbits were repeated. Rabbits without radiologic vasospasm or spasm under 50% (n=7) were termed as group 1. Rabbits whose cerebral vasospasm were 50% or over 50% (n=7) and NSS is lesser than 3 were termed as groups 2, and rabbits whose cerebral vasospasm were 50% or above 50% (n=7) and NSS is greater than 3 were termed groups 3. On day 7, the CSF lactate values of each group were significantly different (P<0.05) with each other. But when compared with only CSF baseline lactate values groups 2 and 3 were significantly different (P<0.05). However, the NSSs were similar in groups 1 and 2, but group 3 significantly differed from groups 1 and 2 (P<0.05). All groups significantly differed from baseline NSSs (P<0.05). The data showed clearly that the degree of vasospasm correlates not only with neurologic status but also with CSF lactate levels. We suggest that CSF lactate level may be useful as a surrogate marker of cerebral vasospasm degree after subarachnoid hemorrhage in clinics where invasive cerebral angiography could not be assessed for whatever reasons.</abstract><cop>United States</cop><pmid>17592347</pmid><doi>10.1097/ANA.0b013e3180461278</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Basilar Artery - diagnostic imaging Biomarkers - cerebrospinal fluid Cisterna Magna Disease Models, Animal Lactic Acid - cerebrospinal fluid Male Nervous System Diseases - cerebrospinal fluid Rabbits Radiography Severity of Illness Index Subarachnoid Hemorrhage - cerebrospinal fluid Subarachnoid Hemorrhage - complications Vasospasm, Intracranial - complications Vasospasm, Intracranial - diagnosis Vertebral Artery - diagnostic imaging |
| title | Lactate contents from cerebrospinal fluid in experimental subarachnoid hemorrhage, well correlate with vasospasm: ongoing and neurologic status |
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