Synthesis and In Vitro Antiproliferative Activity of New 1,3-(Oxytetraethylenoxy)-cyclotriphosphazene Derivatives
A new series of 1,3-(oxytetraethylenoxy)-cyclotriphosphazene derivatives containing aziridine or salicylaldehyde (2-hydroxybenzaldehyde) or its Schiff base units after condensation with 2-chloroethylamine and anthraquinone groups as co-substituents has been synthesized. Their cytostatic activity in...
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| Veröffentlicht in: | Anticancer research 2007-05, Vol.27 (3B), p.1553-1558 |
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| container_issue | 3B |
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| container_title | Anticancer research |
| container_volume | 27 |
| creator | SIWY, Mariola SEK, Danuta KACZMARCZYK, Bozena WIETRZYK, Joanna NASULEWICZ, Anna OPOLSKI, Adam |
| description | A new series of 1,3-(oxytetraethylenoxy)-cyclotriphosphazene derivatives containing aziridine or salicylaldehyde (2-hydroxybenzaldehyde)
or its Schiff base units after condensation with 2-chloroethylamine and anthraquinone groups as co-substituents has been synthesized.
Their cytostatic activity in vitro against the HL-60, A549 and HCV29T cancer cell lines has been studied. Some of the compounds
exhibited antiproliferative activity in the range of the international criteria for synthetic agents (4 μg/ml) against the
cell lines being tested. |
| format | Article |
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or its Schiff base units after condensation with 2-chloroethylamine and anthraquinone groups as co-substituents has been synthesized.
Their cytostatic activity in vitro against the HL-60, A549 and HCV29T cancer cell lines has been studied. Some of the compounds
exhibited antiproliferative activity in the range of the international criteria for synthetic agents (4 μg/ml) against the
cell lines being tested.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 17595775</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Aziridines - chemistry ; Benzaldehydes - chemical synthesis ; Benzaldehydes - chemistry ; Benzaldehydes - pharmacology ; Biological and medical sciences ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Humans ; Medical sciences ; Organophosphorus Compounds - chemical synthesis ; Organophosphorus Compounds - chemistry ; Organophosphorus Compounds - pharmacology ; Tumors</subject><ispartof>Anticancer research, 2007-05, Vol.27 (3B), p.1553-1558</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18853788$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17595775$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SIWY, Mariola</creatorcontrib><creatorcontrib>SEK, Danuta</creatorcontrib><creatorcontrib>KACZMARCZYK, Bozena</creatorcontrib><creatorcontrib>WIETRZYK, Joanna</creatorcontrib><creatorcontrib>NASULEWICZ, Anna</creatorcontrib><creatorcontrib>OPOLSKI, Adam</creatorcontrib><title>Synthesis and In Vitro Antiproliferative Activity of New 1,3-(Oxytetraethylenoxy)-cyclotriphosphazene Derivatives</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>A new series of 1,3-(oxytetraethylenoxy)-cyclotriphosphazene derivatives containing aziridine or salicylaldehyde (2-hydroxybenzaldehyde)
or its Schiff base units after condensation with 2-chloroethylamine and anthraquinone groups as co-substituents has been synthesized.
Their cytostatic activity in vitro against the HL-60, A549 and HCV29T cancer cell lines has been studied. Some of the compounds
exhibited antiproliferative activity in the range of the international criteria for synthetic agents (4 μg/ml) against the
cell lines being tested.</description><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Aziridines - chemistry</subject><subject>Benzaldehydes - chemical synthesis</subject><subject>Benzaldehydes - chemistry</subject><subject>Benzaldehydes - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Organophosphorus Compounds - chemical synthesis</subject><subject>Organophosphorus Compounds - chemistry</subject><subject>Organophosphorus Compounds - pharmacology</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkElPwzAYRCMEomX5C8gXEEhEsmO85FjKVgnBgeUaufZnYuQmxXaX8OuJoKinuTy90cxONiSiJLlgFO9mQ1wwnAuM2SA7iPETY85LSfezARGsZEKwYfb10jWphugiUo1Bkwa9uxRaNGqSm4fWOwtBJbcENNJ9uNSh1qInWCFySfPz53WXIAUFqe48NO26u8h1p32bgpvXbZzX6hsaQDcQ3PLXE4-yPat8hONNHmZvd7ev44f88fl-Mh495nUhcMo5K_gUtKHGaGst2Cm5MoJyWpZAtOBgrhTnEktDlcHAFZWimEpmiVWcGKCH2dmft5_xtYCYqpmLGrxXDbSLWIn-DVKIogdPNuBiOgNTzYObqdBV_yf1wOkGUFErb4NqtItbTkpGhZTbxtp91CsXoIoz5X2vpZUKhajodUUYo_QHPhaBKw</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>SIWY, Mariola</creator><creator>SEK, Danuta</creator><creator>KACZMARCZYK, Bozena</creator><creator>WIETRZYK, Joanna</creator><creator>NASULEWICZ, Anna</creator><creator>OPOLSKI, Adam</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Synthesis and In Vitro Antiproliferative Activity of New 1,3-(Oxytetraethylenoxy)-cyclotriphosphazene Derivatives</title><author>SIWY, Mariola ; SEK, Danuta ; KACZMARCZYK, Bozena ; WIETRZYK, Joanna ; NASULEWICZ, Anna ; OPOLSKI, Adam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h270t-6526becd3ddcfffefb14d736399e1c76ed4a66808d3ad0e6a3872b85f1fa61de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Aziridines - chemistry</topic><topic>Benzaldehydes - chemical synthesis</topic><topic>Benzaldehydes - chemistry</topic><topic>Benzaldehydes - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Organophosphorus Compounds - chemical synthesis</topic><topic>Organophosphorus Compounds - chemistry</topic><topic>Organophosphorus Compounds - pharmacology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SIWY, Mariola</creatorcontrib><creatorcontrib>SEK, Danuta</creatorcontrib><creatorcontrib>KACZMARCZYK, Bozena</creatorcontrib><creatorcontrib>WIETRZYK, Joanna</creatorcontrib><creatorcontrib>NASULEWICZ, Anna</creatorcontrib><creatorcontrib>OPOLSKI, Adam</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SIWY, Mariola</au><au>SEK, Danuta</au><au>KACZMARCZYK, Bozena</au><au>WIETRZYK, Joanna</au><au>NASULEWICZ, Anna</au><au>OPOLSKI, Adam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and In Vitro Antiproliferative Activity of New 1,3-(Oxytetraethylenoxy)-cyclotriphosphazene Derivatives</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>27</volume><issue>3B</issue><spage>1553</spage><epage>1558</epage><pages>1553-1558</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>A new series of 1,3-(oxytetraethylenoxy)-cyclotriphosphazene derivatives containing aziridine or salicylaldehyde (2-hydroxybenzaldehyde)
or its Schiff base units after condensation with 2-chloroethylamine and anthraquinone groups as co-substituents has been synthesized.
Their cytostatic activity in vitro against the HL-60, A549 and HCV29T cancer cell lines has been studied. Some of the compounds
exhibited antiproliferative activity in the range of the international criteria for synthetic agents (4 μg/ml) against the
cell lines being tested.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>17595775</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Anticancer research, 2007-05, Vol.27 (3B), p.1553-1558 |
| issn | 0250-7005 1791-7530 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Aziridines - chemistry Benzaldehydes - chemical synthesis Benzaldehydes - chemistry Benzaldehydes - pharmacology Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects Humans Medical sciences Organophosphorus Compounds - chemical synthesis Organophosphorus Compounds - chemistry Organophosphorus Compounds - pharmacology Tumors |
| title | Synthesis and In Vitro Antiproliferative Activity of New 1,3-(Oxytetraethylenoxy)-cyclotriphosphazene Derivatives |
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