Human cytomegalovirus-encoded US2 and US11 target unassembled MHC class I heavy chains for degradation

Surface MHC class I molecules serve important immune functions as ligands for both T and NK cell receptors for the elimination of infected and malignant cells. In order to reach the cell surface, MHC class I molecules have to fold properly and form trimers consisting of a heavy chain (HC), a β 2-mic...

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