The oncogene and developmental regulator EVI1: Expression, biochemical properties, and biological functions

The EVI1 gene codes for a zinc finger transcription factor with important roles both in normal development and in leukemogenesis. Transcriptional activation of this gene through chromosome rearrangements or other, yet to be identified mechanisms leads to particularly aggressive forms of human myeloi...

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Veröffentlicht in:	Gene 2007-07, Vol.396 (2), p.346-357
1. Verfasser:	Wieser, Rotraud
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Chromosomes - ultrastructure DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Gene Expression Regulation, Neoplastic Humans Leukemia, Myeloid - genetics Leukemia, Myeloid - metabolism MDS1 and EVI1 Complex Locus Protein Mice Mouse model Myelodysplastic syndrome Myelodysplastic Syndromes - genetics Myeloid leukemia Oncogenes Protein Structure, Tertiary Proto-Oncogenes - genetics Proto-Oncogenes - physiology Transcription factor Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Transcription, Genetic Transforming Growth Factor beta - metabolism Zinc finger protein Zinc Fingers
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