The oncogene and developmental regulator EVI1: Expression, biochemical properties, and biological functions
The EVI1 gene codes for a zinc finger transcription factor with important roles both in normal development and in leukemogenesis. Transcriptional activation of this gene through chromosome rearrangements or other, yet to be identified mechanisms leads to particularly aggressive forms of human myeloi...
Gespeichert in:
| Veröffentlicht in: | Gene 2007-07, Vol.396 (2), p.346-357 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 357 |
|---|---|
| container_issue | 2 |
| container_start_page | 346 |
| container_title | Gene |
| container_volume | 396 |
| creator | Wieser, Rotraud |
| description | The
EVI1 gene codes for a zinc finger transcription factor with important roles both in normal development and in leukemogenesis. Transcriptional activation of this gene through chromosome rearrangements or other, yet to be identified mechanisms leads to particularly aggressive forms of human myeloid leukemia. In vitro as well as in animal model systems, EVI1 affected cellular proliferation, differentiation, and apoptosis in cell type specific ways. Retroviral integrations into the EVI1 locus provided cells with increased abilities to engraft, survive, and proliferate in bone marrow transplantation experiments. Experimental overexpression of EVI1 by itself was insufficient to cause leukemia in animal model systems, but it cooperated with other genes in this process.
This review summarizes the currently available experimental evidence for the proposed biochemical and biological functions of this important oncogene. |
| doi_str_mv | 10.1016/j.gene.2007.04.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70660558</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378111907001849</els_id><sourcerecordid>19958379</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-6d6c56dcc23d4840d0d977dfcbfadc9c2a2e8b4ca77b0c26697ba053eb1a1a193</originalsourceid><addsrcrecordid>eNqFkU1P3DAQhi0Egi3tH-CAcuJEwjhfThAXhLYtEhIX2qvljCeLlyQOdoLov6_DrtRbsQ8-zDOPrPdl7IxDwoGXV9tkQwMlKYBIIE-ApwdsxStRxwBZdchWkIkq5pzXJ-yL91sIpyjSY3bCRQGCV9mKvTw9U2QHtIsqUoOONL1RZ8eehkl1kaPN3KnJumj9-55fR-v30ZH3xg6XUWMsPlNvMHCjsyO5yZC__LCEWWc3H6N2HnAKC_4rO2pV5-nb_j1lv76vn-5-xg-PP-7vbh9izKpiiktdYlFqxDTTeZWDBl0LoVtsWqWxxlSlVDU5KiEawLQsa9EoKDJquAq3zk7Zxc4bPvU6k59kbzxS16mB7OylgLIMQVSfgryuAyUWY7oD0VnvHbVydKZX7o_kIJcu5FYuAcqlCwm5DF2EpfO9fW560v9W9uEH4GYHUAjjzZCTHg0NSNo4wklqa_7n_wuk5pyo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19958379</pqid></control><display><type>article</type><title>The oncogene and developmental regulator EVI1: Expression, biochemical properties, and biological functions</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Wieser, Rotraud</creator><creatorcontrib>Wieser, Rotraud</creatorcontrib><description>The
EVI1 gene codes for a zinc finger transcription factor with important roles both in normal development and in leukemogenesis. Transcriptional activation of this gene through chromosome rearrangements or other, yet to be identified mechanisms leads to particularly aggressive forms of human myeloid leukemia. In vitro as well as in animal model systems, EVI1 affected cellular proliferation, differentiation, and apoptosis in cell type specific ways. Retroviral integrations into the EVI1 locus provided cells with increased abilities to engraft, survive, and proliferate in bone marrow transplantation experiments. Experimental overexpression of EVI1 by itself was insufficient to cause leukemia in animal model systems, but it cooperated with other genes in this process.
This review summarizes the currently available experimental evidence for the proposed biochemical and biological functions of this important oncogene.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/j.gene.2007.04.012</identifier><identifier>PMID: 17507183</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Cell Proliferation ; Chromosomes - ultrastructure ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - physiology ; Gene Expression Regulation, Neoplastic ; Humans ; Leukemia, Myeloid - genetics ; Leukemia, Myeloid - metabolism ; MDS1 and EVI1 Complex Locus Protein ; Mice ; Mouse model ; Myelodysplastic syndrome ; Myelodysplastic Syndromes - genetics ; Myeloid leukemia ; Oncogenes ; Protein Structure, Tertiary ; Proto-Oncogenes - genetics ; Proto-Oncogenes - physiology ; Transcription factor ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transcription Factors - physiology ; Transcription, Genetic ; Transforming Growth Factor beta - metabolism ; Zinc finger protein ; Zinc Fingers</subject><ispartof>Gene, 2007-07, Vol.396 (2), p.346-357</ispartof><rights>2007 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-6d6c56dcc23d4840d0d977dfcbfadc9c2a2e8b4ca77b0c26697ba053eb1a1a193</citedby><cites>FETCH-LOGICAL-c385t-6d6c56dcc23d4840d0d977dfcbfadc9c2a2e8b4ca77b0c26697ba053eb1a1a193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.gene.2007.04.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17507183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wieser, Rotraud</creatorcontrib><title>The oncogene and developmental regulator EVI1: Expression, biochemical properties, and biological functions</title><title>Gene</title><addtitle>Gene</addtitle><description>The
EVI1 gene codes for a zinc finger transcription factor with important roles both in normal development and in leukemogenesis. Transcriptional activation of this gene through chromosome rearrangements or other, yet to be identified mechanisms leads to particularly aggressive forms of human myeloid leukemia. In vitro as well as in animal model systems, EVI1 affected cellular proliferation, differentiation, and apoptosis in cell type specific ways. Retroviral integrations into the EVI1 locus provided cells with increased abilities to engraft, survive, and proliferate in bone marrow transplantation experiments. Experimental overexpression of EVI1 by itself was insufficient to cause leukemia in animal model systems, but it cooperated with other genes in this process.
This review summarizes the currently available experimental evidence for the proposed biochemical and biological functions of this important oncogene.</description><subject>Animals</subject><subject>Cell Proliferation</subject><subject>Chromosomes - ultrastructure</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Leukemia, Myeloid - genetics</subject><subject>Leukemia, Myeloid - metabolism</subject><subject>MDS1 and EVI1 Complex Locus Protein</subject><subject>Mice</subject><subject>Mouse model</subject><subject>Myelodysplastic syndrome</subject><subject>Myelodysplastic Syndromes - genetics</subject><subject>Myeloid leukemia</subject><subject>Oncogenes</subject><subject>Protein Structure, Tertiary</subject><subject>Proto-Oncogenes - genetics</subject><subject>Proto-Oncogenes - physiology</subject><subject>Transcription factor</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription Factors - physiology</subject><subject>Transcription, Genetic</subject><subject>Transforming Growth Factor beta - metabolism</subject><subject>Zinc finger protein</subject><subject>Zinc Fingers</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhi0Egi3tH-CAcuJEwjhfThAXhLYtEhIX2qvljCeLlyQOdoLov6_DrtRbsQ8-zDOPrPdl7IxDwoGXV9tkQwMlKYBIIE-ApwdsxStRxwBZdchWkIkq5pzXJ-yL91sIpyjSY3bCRQGCV9mKvTw9U2QHtIsqUoOONL1RZ8eehkl1kaPN3KnJumj9-55fR-v30ZH3xg6XUWMsPlNvMHCjsyO5yZC__LCEWWc3H6N2HnAKC_4rO2pV5-nb_j1lv76vn-5-xg-PP-7vbh9izKpiiktdYlFqxDTTeZWDBl0LoVtsWqWxxlSlVDU5KiEawLQsa9EoKDJquAq3zk7Zxc4bPvU6k59kbzxS16mB7OylgLIMQVSfgryuAyUWY7oD0VnvHbVydKZX7o_kIJcu5FYuAcqlCwm5DF2EpfO9fW560v9W9uEH4GYHUAjjzZCTHg0NSNo4wklqa_7n_wuk5pyo</recordid><startdate>20070715</startdate><enddate>20070715</enddate><creator>Wieser, Rotraud</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070715</creationdate><title>The oncogene and developmental regulator EVI1: Expression, biochemical properties, and biological functions</title><author>Wieser, Rotraud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-6d6c56dcc23d4840d0d977dfcbfadc9c2a2e8b4ca77b0c26697ba053eb1a1a193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Cell Proliferation</topic><topic>Chromosomes - ultrastructure</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Leukemia, Myeloid - genetics</topic><topic>Leukemia, Myeloid - metabolism</topic><topic>MDS1 and EVI1 Complex Locus Protein</topic><topic>Mice</topic><topic>Mouse model</topic><topic>Myelodysplastic syndrome</topic><topic>Myelodysplastic Syndromes - genetics</topic><topic>Myeloid leukemia</topic><topic>Oncogenes</topic><topic>Protein Structure, Tertiary</topic><topic>Proto-Oncogenes - genetics</topic><topic>Proto-Oncogenes - physiology</topic><topic>Transcription factor</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription Factors - physiology</topic><topic>Transcription, Genetic</topic><topic>Transforming Growth Factor beta - metabolism</topic><topic>Zinc finger protein</topic><topic>Zinc Fingers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wieser, Rotraud</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wieser, Rotraud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The oncogene and developmental regulator EVI1: Expression, biochemical properties, and biological functions</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>2007-07-15</date><risdate>2007</risdate><volume>396</volume><issue>2</issue><spage>346</spage><epage>357</epage><pages>346-357</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>The
EVI1 gene codes for a zinc finger transcription factor with important roles both in normal development and in leukemogenesis. Transcriptional activation of this gene through chromosome rearrangements or other, yet to be identified mechanisms leads to particularly aggressive forms of human myeloid leukemia. In vitro as well as in animal model systems, EVI1 affected cellular proliferation, differentiation, and apoptosis in cell type specific ways. Retroviral integrations into the EVI1 locus provided cells with increased abilities to engraft, survive, and proliferate in bone marrow transplantation experiments. Experimental overexpression of EVI1 by itself was insufficient to cause leukemia in animal model systems, but it cooperated with other genes in this process.
This review summarizes the currently available experimental evidence for the proposed biochemical and biological functions of this important oncogene.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>17507183</pmid><doi>10.1016/j.gene.2007.04.012</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-1119 |
| ispartof | Gene, 2007-07, Vol.396 (2), p.346-357 |
| issn | 0378-1119 1879-0038 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70660558 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Cell Proliferation Chromosomes - ultrastructure DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Gene Expression Regulation, Neoplastic Humans Leukemia, Myeloid - genetics Leukemia, Myeloid - metabolism MDS1 and EVI1 Complex Locus Protein Mice Mouse model Myelodysplastic syndrome Myelodysplastic Syndromes - genetics Myeloid leukemia Oncogenes Protein Structure, Tertiary Proto-Oncogenes - genetics Proto-Oncogenes - physiology Transcription factor Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Transcription, Genetic Transforming Growth Factor beta - metabolism Zinc finger protein Zinc Fingers |
| title | The oncogene and developmental regulator EVI1: Expression, biochemical properties, and biological functions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T10%3A22%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20oncogene%20and%20developmental%20regulator%20EVI1:%20Expression,%20biochemical%20properties,%20and%20biological%20functions&rft.jtitle=Gene&rft.au=Wieser,%20Rotraud&rft.date=2007-07-15&rft.volume=396&rft.issue=2&rft.spage=346&rft.epage=357&rft.pages=346-357&rft.issn=0378-1119&rft.eissn=1879-0038&rft_id=info:doi/10.1016/j.gene.2007.04.012&rft_dat=%3Cproquest_cross%3E19958379%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19958379&rft_id=info:pmid/17507183&rft_els_id=S0378111907001849&rfr_iscdi=true |