Prognostic value of hyaluronan expression in non‐small‐cell lung cancer: Increased stromal expression indicates unfavorable outcome in patients with adenocarcinoma

The prognostic value of hyaluronan (HA) was analyzed in a large number of patients (n = 261) with non‐small‐cell lung cancer (NSCLC) by staining archived tumor samples with a biotinylated HA‐specific probe. The level of HA in the tumor cells and surrounding stroma was scored and compared with parall...

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Veröffentlicht in:	International journal of cancer 2001-01, Vol.95 (1), p.12-17
Hauptverfasser:	Pirinen, Risto, Tammi, Raija, Tammi, Markku, Hirvikoski, Pasi, Parkkinen, Jyrki J., Johansson, Risto, Böhm, Jan, Hollmén, Sinikka, Kosma, Veli‐Matti
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - therapy Adult Aged Biological and medical sciences Carcinoma - metabolism Carcinoma - mortality Carcinoma - therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - therapy CD44 Cohort Studies Disease-Free Survival extracellular matrix Female Follow-Up Studies Humans hyaluronan Hyaluronan Receptors - metabolism Hyaluronic Acid - biosynthesis Immunohistochemistry lung cancer Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - therapy Male Medical sciences Middle Aged Multivariate Analysis Pneumology Prognosis Recurrence Stromal Cells - metabolism survival Treatment Outcome Tumors of the respiratory system and mediastinum
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