Oxidative stress and vascular damage in hypertension
Oxidative stress, a state of excessive reactive oxidative species activity, is associated with vascular disease states such as hypertension. In this review, we discuss the recent advances in the field of reactive oxidative species-mediated vascular damage in hypertension. These include the identific...
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| Veröffentlicht in: | Current opinion in nephrology and hypertension 2001-03, Vol.10 (2), p.247-255 |
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| container_title | Current opinion in nephrology and hypertension |
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| creator | Berry, Colin Brosnan, M Julia Fennell, Jerome Hamilton, Carlene A Dominiczak, Anna F |
| description | Oxidative stress, a state of excessive reactive oxidative species activity, is associated with vascular disease states such as hypertension. In this review, we discuss the recent advances in the field of reactive oxidative species-mediated vascular damage in hypertension. These include the identification of redox-sensitive tyrosine kinases, the characterization of enzymatic sources of superoxide production in human blood vessels, and their relationship with vascular damage in atherosclerosis and hypertension. Finally, recent developments in the search for strategies to attenuate vascular oxidative stress are reviewed. |
| doi_str_mv | 10.1097/00041552-200103000-00014 |
| format | Article |
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| issn | 1062-4821 1473-6543 |
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| subjects | Adrenergic beta-Antagonists - pharmacology Angiotensin II - pharmacology Animals Blood Vessels - drug effects Blood Vessels - metabolism Blood Vessels - pathology Cardiovascular Diseases - etiology Cardiovascular Diseases - metabolism Disease Models, Animal Estrogens - pharmacology Gene Transfer Techniques Humans Hydrogen Peroxide - metabolism Hypertension - drug therapy Hypertension - metabolism Hypertension - pathology Mitochondria - metabolism NADH, NADPH Oxidoreductases - metabolism NADPH Oxidases Nitrates - metabolism Nitric Oxide Synthase - metabolism Oxidative Stress - drug effects Rats Reactive Oxygen Species - metabolism Renin-Angiotensin System - drug effects Risk Factors Signal Transduction Superoxide Dismutase - pharmacology Vitamins - pharmacology Xanthine Oxidase - metabolism |
| title | Oxidative stress and vascular damage in hypertension |
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