Identification and Clinical Significance of Mobilized Endothelial Progenitor Cells in Tumor Vasculogenesis of Hepatocellular Carcinoma
Purpose: To investigate the distribution, frequency, and clinical significance of mobilized endothelial progenitor cells (EPC) in hepatocellular carcinoma (HCC). Experimental Design: In healthy controls and patients with HCC, the frequency of circulating EPCs was determined by colony-forming assays,...
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| Veröffentlicht in: | Clinical cancer research 2007-07, Vol.13 (13), p.3814-3824 |
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| creator | Yu, Decai Sun, Xitai Qiu, Yudong Zhou, Jianxing Wu, Yafu Zhuang, Lingyuan Chen, Jun Ding, Yitao |
| description | Purpose: To investigate the distribution, frequency, and clinical significance of mobilized endothelial progenitor cells (EPC) in
hepatocellular carcinoma (HCC).
Experimental Design: In healthy controls and patients with HCC, the frequency of circulating EPCs was determined by colony-forming assays, fluorescence-activated
cell sorting, and real-time PCR. One hundred sixty-five–amino acid form of vascular endothelial growth factor and platelet-derived
growth factor-BB in plasma and tissue were quantified by ELISA. The distribution and frequency of EPCs were evaluated by immunofluorescence,
immunohistochemistry, and real-time PCR in normal liver ( n = 8), and tumor tissue (TT), adjacent nonmalignant liver tissue (AT), and tumor-free tissue 5 cm from the tumor edge (TF)
from 64 patients with HCC. Clinicopathologic data for these patients were evaluated.
Results: Compared with values for healthy controls, colony-forming unit scores were higher in the peripheral blood of patients with
HCC. Plasma 165-amino acid form of vascular endothelial growth factor and platelet-derived growth factor-BB correlated with
the expression level of the AC133 gene, which was also higher in the peripheral blood of patients with HCC. Immunohistochemical analysis showed that EPCs were
incorporated into the microvessels in cirrhotic and tumor tissue. Compared with normal liver (9.00), increased AC133 + microvessel density (microvessels/0.74 mm 2 ) was found in TT (53.56), AT (84.76), and TF (48.33). The levels of AC133 gene expression and AC133-microvessel density in AT, which were the highest among four groups, correlated with clinicopathologic
variables (the absence of tumor capsule, venous invasion, proliferating cell nuclear antigen intensity, and early recurrence).
Conclusions: Mobilized EPCs participate in tumor vasculogenesis of HCC. AC133 gene or antigen in peripheral blood and liver tissue could be used as a biomarker for predicting the progression of HCC. |
| doi_str_mv | 10.1158/1078-0432.CCR-06-2594 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70660407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70660407</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-5f432a66f4f5050b3c11b452bc44c5be9924a4e150ba64d613f6d6595a551e703</originalsourceid><addsrcrecordid>eNpFkV2L1DAUhoMo7of-BCU3LuxF15w2SaeXUlZ3YUXR1duQpiczkTQZkxbRH-DvNt0ZWQgkh_Ocj7wvIa-AXQGIzVtg7aZivKmv-v5LxWRVi44_IacgRFs1tRRPy_s_c0LOcv7BGHBg_Dk5gVYy2UJ9Sv7ejhhmZ53Rs4uB6jDS3rtQYk-_um14SAWDNFr6MQ7Ouz840uswxnmH3hXqc4pbDG6OifbofaYu0PtlKuF3nc3i1yxml9cON7jXczQFW7wuvE7GhTjpF-SZ1T7jy-N9Tr69v77vb6q7Tx9u-3d3lWlamCthy2e0lJZbwQQbGgMwcFEPhnMjBuy6mmuOUFJa8lFCY-UoRSe0EIAta87JxaHvPsWfC-ZZTS6v6-iAccmqZVIyztoCigNoUsw5oVX75CadfitgajVAreKqVVxVDFBMqtWAUvf6OGAZJhwfq46KF-DNESjiaG9TEdflR27T1WUDWbjLA7dz290vl1A92JASZiyq7RQ062k2wJt_0PqeRg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70660407</pqid></control><display><type>article</type><title>Identification and Clinical Significance of Mobilized Endothelial Progenitor Cells in Tumor Vasculogenesis of Hepatocellular Carcinoma</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Yu, Decai ; Sun, Xitai ; Qiu, Yudong ; Zhou, Jianxing ; Wu, Yafu ; Zhuang, Lingyuan ; Chen, Jun ; Ding, Yitao</creator><creatorcontrib>Yu, Decai ; Sun, Xitai ; Qiu, Yudong ; Zhou, Jianxing ; Wu, Yafu ; Zhuang, Lingyuan ; Chen, Jun ; Ding, Yitao</creatorcontrib><description>Purpose: To investigate the distribution, frequency, and clinical significance of mobilized endothelial progenitor cells (EPC) in
hepatocellular carcinoma (HCC).
Experimental Design: In healthy controls and patients with HCC, the frequency of circulating EPCs was determined by colony-forming assays, fluorescence-activated
cell sorting, and real-time PCR. One hundred sixty-five–amino acid form of vascular endothelial growth factor and platelet-derived
growth factor-BB in plasma and tissue were quantified by ELISA. The distribution and frequency of EPCs were evaluated by immunofluorescence,
immunohistochemistry, and real-time PCR in normal liver ( n = 8), and tumor tissue (TT), adjacent nonmalignant liver tissue (AT), and tumor-free tissue 5 cm from the tumor edge (TF)
from 64 patients with HCC. Clinicopathologic data for these patients were evaluated.
Results: Compared with values for healthy controls, colony-forming unit scores were higher in the peripheral blood of patients with
HCC. Plasma 165-amino acid form of vascular endothelial growth factor and platelet-derived growth factor-BB correlated with
the expression level of the AC133 gene, which was also higher in the peripheral blood of patients with HCC. Immunohistochemical analysis showed that EPCs were
incorporated into the microvessels in cirrhotic and tumor tissue. Compared with normal liver (9.00), increased AC133 + microvessel density (microvessels/0.74 mm 2 ) was found in TT (53.56), AT (84.76), and TF (48.33). The levels of AC133 gene expression and AC133-microvessel density in AT, which were the highest among four groups, correlated with clinicopathologic
variables (the absence of tumor capsule, venous invasion, proliferating cell nuclear antigen intensity, and early recurrence).
Conclusions: Mobilized EPCs participate in tumor vasculogenesis of HCC. AC133 gene or antigen in peripheral blood and liver tissue could be used as a biomarker for predicting the progression of HCC.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-06-2594</identifier><identifier>PMID: 17606712</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>AC133 ; AC133 Antigen ; Adult ; Antigens, CD - biosynthesis ; Antigens, CD34 - biosynthesis ; Antineoplastic agents ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Endothelial Cells - cytology ; Endothelial progenitor cells ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Glycoproteins - biosynthesis ; Hepatocellular carcinoma ; Humans ; Liver Neoplasms - diagnosis ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Neovascularization ; Neovascularization, Pathologic ; Peptides ; Pharmacology. Drug treatments ; Platelet-Derived Growth Factor - biosynthesis ; Postal vasculogenesis ; Proto-Oncogene Proteins c-sis ; Stem Cells - cytology ; Tumors ; Vascular Endothelial Growth Factor A - blood</subject><ispartof>Clinical cancer research, 2007-07, Vol.13 (13), p.3814-3824</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-5f432a66f4f5050b3c11b452bc44c5be9924a4e150ba64d613f6d6595a551e703</citedby><cites>FETCH-LOGICAL-c371t-5f432a66f4f5050b3c11b452bc44c5be9924a4e150ba64d613f6d6595a551e703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3354,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18926046$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17606712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Decai</creatorcontrib><creatorcontrib>Sun, Xitai</creatorcontrib><creatorcontrib>Qiu, Yudong</creatorcontrib><creatorcontrib>Zhou, Jianxing</creatorcontrib><creatorcontrib>Wu, Yafu</creatorcontrib><creatorcontrib>Zhuang, Lingyuan</creatorcontrib><creatorcontrib>Chen, Jun</creatorcontrib><creatorcontrib>Ding, Yitao</creatorcontrib><title>Identification and Clinical Significance of Mobilized Endothelial Progenitor Cells in Tumor Vasculogenesis of Hepatocellular Carcinoma</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Purpose: To investigate the distribution, frequency, and clinical significance of mobilized endothelial progenitor cells (EPC) in
hepatocellular carcinoma (HCC).
Experimental Design: In healthy controls and patients with HCC, the frequency of circulating EPCs was determined by colony-forming assays, fluorescence-activated
cell sorting, and real-time PCR. One hundred sixty-five–amino acid form of vascular endothelial growth factor and platelet-derived
growth factor-BB in plasma and tissue were quantified by ELISA. The distribution and frequency of EPCs were evaluated by immunofluorescence,
immunohistochemistry, and real-time PCR in normal liver ( n = 8), and tumor tissue (TT), adjacent nonmalignant liver tissue (AT), and tumor-free tissue 5 cm from the tumor edge (TF)
from 64 patients with HCC. Clinicopathologic data for these patients were evaluated.
Results: Compared with values for healthy controls, colony-forming unit scores were higher in the peripheral blood of patients with
HCC. Plasma 165-amino acid form of vascular endothelial growth factor and platelet-derived growth factor-BB correlated with
the expression level of the AC133 gene, which was also higher in the peripheral blood of patients with HCC. Immunohistochemical analysis showed that EPCs were
incorporated into the microvessels in cirrhotic and tumor tissue. Compared with normal liver (9.00), increased AC133 + microvessel density (microvessels/0.74 mm 2 ) was found in TT (53.56), AT (84.76), and TF (48.33). The levels of AC133 gene expression and AC133-microvessel density in AT, which were the highest among four groups, correlated with clinicopathologic
variables (the absence of tumor capsule, venous invasion, proliferating cell nuclear antigen intensity, and early recurrence).
Conclusions: Mobilized EPCs participate in tumor vasculogenesis of HCC. AC133 gene or antigen in peripheral blood and liver tissue could be used as a biomarker for predicting the progression of HCC.</description><subject>AC133</subject><subject>AC133 Antigen</subject><subject>Adult</subject><subject>Antigens, CD - biosynthesis</subject><subject>Antigens, CD34 - biosynthesis</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Endothelial Cells - cytology</subject><subject>Endothelial progenitor cells</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Glycoproteins - biosynthesis</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neovascularization</subject><subject>Neovascularization, Pathologic</subject><subject>Peptides</subject><subject>Pharmacology. Drug treatments</subject><subject>Platelet-Derived Growth Factor - biosynthesis</subject><subject>Postal vasculogenesis</subject><subject>Proto-Oncogene Proteins c-sis</subject><subject>Stem Cells - cytology</subject><subject>Tumors</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkV2L1DAUhoMo7of-BCU3LuxF15w2SaeXUlZ3YUXR1duQpiczkTQZkxbRH-DvNt0ZWQgkh_Ocj7wvIa-AXQGIzVtg7aZivKmv-v5LxWRVi44_IacgRFs1tRRPy_s_c0LOcv7BGHBg_Dk5gVYy2UJ9Sv7ejhhmZ53Rs4uB6jDS3rtQYk-_um14SAWDNFr6MQ7Ouz840uswxnmH3hXqc4pbDG6OifbofaYu0PtlKuF3nc3i1yxml9cON7jXczQFW7wuvE7GhTjpF-SZ1T7jy-N9Tr69v77vb6q7Tx9u-3d3lWlamCthy2e0lJZbwQQbGgMwcFEPhnMjBuy6mmuOUFJa8lFCY-UoRSe0EIAta87JxaHvPsWfC-ZZTS6v6-iAccmqZVIyztoCigNoUsw5oVX75CadfitgajVAreKqVVxVDFBMqtWAUvf6OGAZJhwfq46KF-DNESjiaG9TEdflR27T1WUDWbjLA7dz290vl1A92JASZiyq7RQ062k2wJt_0PqeRg</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Yu, Decai</creator><creator>Sun, Xitai</creator><creator>Qiu, Yudong</creator><creator>Zhou, Jianxing</creator><creator>Wu, Yafu</creator><creator>Zhuang, Lingyuan</creator><creator>Chen, Jun</creator><creator>Ding, Yitao</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070701</creationdate><title>Identification and Clinical Significance of Mobilized Endothelial Progenitor Cells in Tumor Vasculogenesis of Hepatocellular Carcinoma</title><author>Yu, Decai ; Sun, Xitai ; Qiu, Yudong ; Zhou, Jianxing ; Wu, Yafu ; Zhuang, Lingyuan ; Chen, Jun ; Ding, Yitao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-5f432a66f4f5050b3c11b452bc44c5be9924a4e150ba64d613f6d6595a551e703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>AC133</topic><topic>AC133 Antigen</topic><topic>Adult</topic><topic>Antigens, CD - biosynthesis</topic><topic>Antigens, CD34 - biosynthesis</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Endothelial Cells - cytology</topic><topic>Endothelial progenitor cells</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Glycoproteins - biosynthesis</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neovascularization</topic><topic>Neovascularization, Pathologic</topic><topic>Peptides</topic><topic>Pharmacology. Drug treatments</topic><topic>Platelet-Derived Growth Factor - biosynthesis</topic><topic>Postal vasculogenesis</topic><topic>Proto-Oncogene Proteins c-sis</topic><topic>Stem Cells - cytology</topic><topic>Tumors</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Decai</creatorcontrib><creatorcontrib>Sun, Xitai</creatorcontrib><creatorcontrib>Qiu, Yudong</creatorcontrib><creatorcontrib>Zhou, Jianxing</creatorcontrib><creatorcontrib>Wu, Yafu</creatorcontrib><creatorcontrib>Zhuang, Lingyuan</creatorcontrib><creatorcontrib>Chen, Jun</creatorcontrib><creatorcontrib>Ding, Yitao</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Decai</au><au>Sun, Xitai</au><au>Qiu, Yudong</au><au>Zhou, Jianxing</au><au>Wu, Yafu</au><au>Zhuang, Lingyuan</au><au>Chen, Jun</au><au>Ding, Yitao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification and Clinical Significance of Mobilized Endothelial Progenitor Cells in Tumor Vasculogenesis of Hepatocellular Carcinoma</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>13</volume><issue>13</issue><spage>3814</spage><epage>3824</epage><pages>3814-3824</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Purpose: To investigate the distribution, frequency, and clinical significance of mobilized endothelial progenitor cells (EPC) in
hepatocellular carcinoma (HCC).
Experimental Design: In healthy controls and patients with HCC, the frequency of circulating EPCs was determined by colony-forming assays, fluorescence-activated
cell sorting, and real-time PCR. One hundred sixty-five–amino acid form of vascular endothelial growth factor and platelet-derived
growth factor-BB in plasma and tissue were quantified by ELISA. The distribution and frequency of EPCs were evaluated by immunofluorescence,
immunohistochemistry, and real-time PCR in normal liver ( n = 8), and tumor tissue (TT), adjacent nonmalignant liver tissue (AT), and tumor-free tissue 5 cm from the tumor edge (TF)
from 64 patients with HCC. Clinicopathologic data for these patients were evaluated.
Results: Compared with values for healthy controls, colony-forming unit scores were higher in the peripheral blood of patients with
HCC. Plasma 165-amino acid form of vascular endothelial growth factor and platelet-derived growth factor-BB correlated with
the expression level of the AC133 gene, which was also higher in the peripheral blood of patients with HCC. Immunohistochemical analysis showed that EPCs were
incorporated into the microvessels in cirrhotic and tumor tissue. Compared with normal liver (9.00), increased AC133 + microvessel density (microvessels/0.74 mm 2 ) was found in TT (53.56), AT (84.76), and TF (48.33). The levels of AC133 gene expression and AC133-microvessel density in AT, which were the highest among four groups, correlated with clinicopathologic
variables (the absence of tumor capsule, venous invasion, proliferating cell nuclear antigen intensity, and early recurrence).
Conclusions: Mobilized EPCs participate in tumor vasculogenesis of HCC. AC133 gene or antigen in peripheral blood and liver tissue could be used as a biomarker for predicting the progression of HCC.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>17606712</pmid><doi>10.1158/1078-0432.CCR-06-2594</doi><tpages>11</tpages></addata></record> |
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| ispartof | Clinical cancer research, 2007-07, Vol.13 (13), p.3814-3824 |
| issn | 1078-0432 1557-3265 |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | AC133 AC133 Antigen Adult Antigens, CD - biosynthesis Antigens, CD34 - biosynthesis Antineoplastic agents Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Endothelial Cells - cytology Endothelial progenitor cells Female Gastroenterology. Liver. Pancreas. Abdomen Glycoproteins - biosynthesis Hepatocellular carcinoma Humans Liver Neoplasms - diagnosis Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Neovascularization Neovascularization, Pathologic Peptides Pharmacology. Drug treatments Platelet-Derived Growth Factor - biosynthesis Postal vasculogenesis Proto-Oncogene Proteins c-sis Stem Cells - cytology Tumors Vascular Endothelial Growth Factor A - blood |
| title | Identification and Clinical Significance of Mobilized Endothelial Progenitor Cells in Tumor Vasculogenesis of Hepatocellular Carcinoma |
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