Interpretation of the detection of Sarcocystis neurona antibodies in the serum of young horses
Horses that are exposed to Sarcocystis neurona, a causative agent of equine protozoal myeloencephalitis, produce antibodies that are detectable in serum by western blot (WB). A positive test is indicative of exposure to the organism. Positive tests in young horses can be complicated by the presence...
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| Veröffentlicht in: | Veterinary parasitology 2001-02, Vol.95 (2), p.187-195 |
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| container_title | Veterinary parasitology |
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| creator | Cook, A.Grimsley Buechner-Maxwell, V. Morrow, J.K. Ward, D.L. Parker, N.A. Dascanio, J.J. Ley, W.B. Cooper, W. |
| description | Horses that are exposed to
Sarcocystis neurona, a causative agent of equine protozoal myeloencephalitis, produce antibodies that are detectable in serum by western blot (WB). A positive test is indicative of exposure to the organism. Positive tests in young horses can be complicated by the presence of maternal antibodies. Passive transfer of maternal antibodies to
S. neurona from seropositive mares to their foals was evaluated. Foals were sampled at birth (presuckle), at 24
h of age (postsuckle), and at monthly intervals. All foals sampled before suckling were seronegative. Thirty-three foals from 33 seropositive mares became seropositive with colostrum ingestion at 24
h of age, confirming that passive transfer of
S. neurona maternal antibodies occurs. Thirty-one of the 33 foals became seronegative by 9 months of age, with a mean seronegative conversion time of 4.2 months. These results indicate that evaluation of exposure to
S. neurona by WB analysis of serum may be misleading in young horses. |
| doi_str_mv | 10.1016/S0304-4017(00)00390-3 |
| format | Article |
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Sarcocystis neurona, a causative agent of equine protozoal myeloencephalitis, produce antibodies that are detectable in serum by western blot (WB). A positive test is indicative of exposure to the organism. Positive tests in young horses can be complicated by the presence of maternal antibodies. Passive transfer of maternal antibodies to
S. neurona from seropositive mares to their foals was evaluated. Foals were sampled at birth (presuckle), at 24
h of age (postsuckle), and at monthly intervals. All foals sampled before suckling were seronegative. Thirty-three foals from 33 seropositive mares became seropositive with colostrum ingestion at 24
h of age, confirming that passive transfer of
S. neurona maternal antibodies occurs. Thirty-one of the 33 foals became seronegative by 9 months of age, with a mean seronegative conversion time of 4.2 months. These results indicate that evaluation of exposure to
S. neurona by WB analysis of serum may be misleading in young horses.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/S0304-4017(00)00390-3</identifier><identifier>PMID: 11223199</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Age Factors ; Animals ; Antibodies, Protozoan - analysis ; Blotting, Western - veterinary ; Colostrum - immunology ; Equine protozoal myeloencephalitis ; Female ; Foals ; Horse Diseases - diagnosis ; Horse Diseases - parasitology ; Horses ; Immunity, Maternally-Acquired ; Immunoglobulin G - analysis ; Immunoglobulins ; Male ; Maternal antibodies ; Passive transfer ; Sarcocystis - immunology ; Sarcocystis - isolation & purification ; Sarcocystis neurona ; Sarcocystosis - diagnosis ; Sarcocystosis - veterinary ; Time Factors ; Western blot</subject><ispartof>Veterinary parasitology, 2001-02, Vol.95 (2), p.187-195</ispartof><rights>2001 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-3f745991bb3d3dc62a5adedab92499e175a3dc5abb57907ca35b16898ec6b6563</citedby><cites>FETCH-LOGICAL-c392t-3f745991bb3d3dc62a5adedab92499e175a3dc5abb57907ca35b16898ec6b6563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-4017(00)00390-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11223199$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cook, A.Grimsley</creatorcontrib><creatorcontrib>Buechner-Maxwell, V.</creatorcontrib><creatorcontrib>Morrow, J.K.</creatorcontrib><creatorcontrib>Ward, D.L.</creatorcontrib><creatorcontrib>Parker, N.A.</creatorcontrib><creatorcontrib>Dascanio, J.J.</creatorcontrib><creatorcontrib>Ley, W.B.</creatorcontrib><creatorcontrib>Cooper, W.</creatorcontrib><title>Interpretation of the detection of Sarcocystis neurona antibodies in the serum of young horses</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>Horses that are exposed to
Sarcocystis neurona, a causative agent of equine protozoal myeloencephalitis, produce antibodies that are detectable in serum by western blot (WB). A positive test is indicative of exposure to the organism. Positive tests in young horses can be complicated by the presence of maternal antibodies. Passive transfer of maternal antibodies to
S. neurona from seropositive mares to their foals was evaluated. Foals were sampled at birth (presuckle), at 24
h of age (postsuckle), and at monthly intervals. All foals sampled before suckling were seronegative. Thirty-three foals from 33 seropositive mares became seropositive with colostrum ingestion at 24
h of age, confirming that passive transfer of
S. neurona maternal antibodies occurs. Thirty-one of the 33 foals became seronegative by 9 months of age, with a mean seronegative conversion time of 4.2 months. These results indicate that evaluation of exposure to
S. neurona by WB analysis of serum may be misleading in young horses.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Antibodies, Protozoan - analysis</subject><subject>Blotting, Western - veterinary</subject><subject>Colostrum - immunology</subject><subject>Equine protozoal myeloencephalitis</subject><subject>Female</subject><subject>Foals</subject><subject>Horse Diseases - diagnosis</subject><subject>Horse Diseases - parasitology</subject><subject>Horses</subject><subject>Immunity, Maternally-Acquired</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulins</subject><subject>Male</subject><subject>Maternal antibodies</subject><subject>Passive transfer</subject><subject>Sarcocystis - immunology</subject><subject>Sarcocystis - isolation & purification</subject><subject>Sarcocystis neurona</subject><subject>Sarcocystosis - diagnosis</subject><subject>Sarcocystosis - veterinary</subject><subject>Time Factors</subject><subject>Western blot</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtrGzEUhUVpqB2nP6FlViVZTHs1GmlGqxBMXhDoIu02Qo_rRsWWHEkT8L_P-NF06dWFw3fugXMI-ULhOwUqfjwCg7ZugXbnABcATELNPpAp7TtWN5zDRzJ9RybkNOe_ANCC6D6RCaVNw6iUU_J0HwqmdcKii4-hiouqPGPlsKD9JzzqZKPd5OJzFXBIMehKh-JNdB5z5cPOkjENqy2-iUP4Uz3HlDGfkZOFXmb8fLgz8vvm-tf8rn74eXs_v3qoLZNNqdmia7mU1BjmmLOi0Vw7dNrIppUSacf1KHNtDO8kdFYzbqjoZY9WGMEFm5Fv-7_rFF8GzEWtfLa4XOqAcciqA8Fl3zdHQdpTKUC2I8j3oE0x54QLtU5-pdNGUVDbBdRuAbWtVwGo3QKKjb6vh4DBrND9dx0qH4HLPYBjH68ek8rWY7DofBo7Vy76IxFv9TeWlA</recordid><startdate>20010226</startdate><enddate>20010226</enddate><creator>Cook, A.Grimsley</creator><creator>Buechner-Maxwell, V.</creator><creator>Morrow, J.K.</creator><creator>Ward, D.L.</creator><creator>Parker, N.A.</creator><creator>Dascanio, J.J.</creator><creator>Ley, W.B.</creator><creator>Cooper, W.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20010226</creationdate><title>Interpretation of the detection of Sarcocystis neurona antibodies in the serum of young horses</title><author>Cook, A.Grimsley ; Buechner-Maxwell, V. ; Morrow, J.K. ; Ward, D.L. ; Parker, N.A. ; Dascanio, J.J. ; Ley, W.B. ; Cooper, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-3f745991bb3d3dc62a5adedab92499e175a3dc5abb57907ca35b16898ec6b6563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Antibodies, Protozoan - analysis</topic><topic>Blotting, Western - veterinary</topic><topic>Colostrum - immunology</topic><topic>Equine protozoal myeloencephalitis</topic><topic>Female</topic><topic>Foals</topic><topic>Horse Diseases - diagnosis</topic><topic>Horse Diseases - parasitology</topic><topic>Horses</topic><topic>Immunity, Maternally-Acquired</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulins</topic><topic>Male</topic><topic>Maternal antibodies</topic><topic>Passive transfer</topic><topic>Sarcocystis - immunology</topic><topic>Sarcocystis - isolation & purification</topic><topic>Sarcocystis neurona</topic><topic>Sarcocystosis - diagnosis</topic><topic>Sarcocystosis - veterinary</topic><topic>Time Factors</topic><topic>Western blot</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cook, A.Grimsley</creatorcontrib><creatorcontrib>Buechner-Maxwell, V.</creatorcontrib><creatorcontrib>Morrow, J.K.</creatorcontrib><creatorcontrib>Ward, D.L.</creatorcontrib><creatorcontrib>Parker, N.A.</creatorcontrib><creatorcontrib>Dascanio, J.J.</creatorcontrib><creatorcontrib>Ley, W.B.</creatorcontrib><creatorcontrib>Cooper, W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cook, A.Grimsley</au><au>Buechner-Maxwell, V.</au><au>Morrow, J.K.</au><au>Ward, D.L.</au><au>Parker, N.A.</au><au>Dascanio, J.J.</au><au>Ley, W.B.</au><au>Cooper, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interpretation of the detection of Sarcocystis neurona antibodies in the serum of young horses</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>2001-02-26</date><risdate>2001</risdate><volume>95</volume><issue>2</issue><spage>187</spage><epage>195</epage><pages>187-195</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>Horses that are exposed to
Sarcocystis neurona, a causative agent of equine protozoal myeloencephalitis, produce antibodies that are detectable in serum by western blot (WB). A positive test is indicative of exposure to the organism. Positive tests in young horses can be complicated by the presence of maternal antibodies. Passive transfer of maternal antibodies to
S. neurona from seropositive mares to their foals was evaluated. Foals were sampled at birth (presuckle), at 24
h of age (postsuckle), and at monthly intervals. All foals sampled before suckling were seronegative. Thirty-three foals from 33 seropositive mares became seropositive with colostrum ingestion at 24
h of age, confirming that passive transfer of
S. neurona maternal antibodies occurs. Thirty-one of the 33 foals became seronegative by 9 months of age, with a mean seronegative conversion time of 4.2 months. These results indicate that evaluation of exposure to
S. neurona by WB analysis of serum may be misleading in young horses.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>11223199</pmid><doi>10.1016/S0304-4017(00)00390-3</doi><tpages>9</tpages></addata></record> |
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| ispartof | Veterinary parasitology, 2001-02, Vol.95 (2), p.187-195 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Age Factors Animals Antibodies, Protozoan - analysis Blotting, Western - veterinary Colostrum - immunology Equine protozoal myeloencephalitis Female Foals Horse Diseases - diagnosis Horse Diseases - parasitology Horses Immunity, Maternally-Acquired Immunoglobulin G - analysis Immunoglobulins Male Maternal antibodies Passive transfer Sarcocystis - immunology Sarcocystis - isolation & purification Sarcocystis neurona Sarcocystosis - diagnosis Sarcocystosis - veterinary Time Factors Western blot |
| title | Interpretation of the detection of Sarcocystis neurona antibodies in the serum of young horses |
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