The hypocholesterolaemic effects of sitostanol in the guinea pig are in part related to changes in hepatic lipids and lipoprotein composition
To evaluate some of the mechanisms involved in the plasma cholesterol lowering of sitostanol (SI), male Hartley guinea pigs were fed diets containing cholesterol (0.25 g/100 g) and four doses of SI: either 0 (control), 0.75, 1.5 or 2.25 g/100 g. In addition a negative control (-C) group with dietary...
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| Veröffentlicht in: | British journal of nutrition 2001-02, Vol.85 (2), p.165-172 |
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| description | To evaluate some of the mechanisms involved in the plasma cholesterol lowering of sitostanol (SI), male Hartley guinea pigs were fed diets containing cholesterol (0.25 g/100 g) and four doses of SI: either 0 (control), 0.75, 1.5 or 2.25 g/100 g. In addition a negative control (-C) group with dietary cholesterol (0.04 g/100 g) was included. Corn oil was used as the source of fat and the contribution of fat energy was 35 %. Plasma total cholesterol was 43, 49 and 53 % (P |
| doi_str_mv | 10.1079/BJN2000246 |
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In addition a negative control (-C) group with dietary cholesterol (0.04 g/100 g) was included. Corn oil was used as the source of fat and the contribution of fat energy was 35 %. Plasma total cholesterol was 43, 49 and 53 % (P<0.0001) lower after SI intake compared to the control. Plasma LDL concentrations were 47, 53 and 61 % lower with increasing doses of SI. In addition, intake of SI resulted in 26–42 % lower hepatic total cholesterol. Hepatic esterified cholesterol and triacylglycerols were 32–60 % and 55–61 % lower after SI intake. SI intake resulted in favourable plasma and hepatic cholesterol concentrations similar to those in guinea pigs fed low levels of dietary cholesterol (-C). The LDL obtained from the control group had a higher number of molecules of free and esterified cholesterol than the SI groups. SI intake resulted in 69–71 % higher cholesterol excretion compared to the control. SI treatment enhanced the total faecal neutral sterol excretion by 54–58 % compared to control and by 70–76 % compared to the (-C) group. These results suggest that SI might have its hypocholesterolaemic effect by reducing cholesterol absorption, which results in lower concentration of cholesterol in liver. This reduction in hepatic cholesterol might possibly alter hepatic cholesterol metabolism and affect lipoprotein concentration and composition.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN2000246</identifier><identifier>PMID: 11242484</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Analysis of Variance ; Animals ; Biological and medical sciences ; Cholesterol ; Cholesterol - analysis ; Cholesterol Esters - analysis ; Cholesterol, LDL - blood ; Cholesterol, LDL - chemistry ; Dietary Fats - administration & dosage ; Dose-Response Relationship, Drug ; Excretion ; Feces - chemistry ; Fundamental and applied biological sciences. Psychology ; Guinea Pigs ; Hepatic lipids ; Hypolipidemic Agents - metabolism ; Hypolipidemic Agents - pharmacology ; Lipids ; Liver - chemistry ; Liver - drug effects ; Liver - metabolism ; Liver. Bile. Biliary tracts ; Male ; Neutral sterols ; Oils & fats ; Sitostanol ; Sitosterols - metabolism ; Sitosterols - pharmacology ; Swine ; Triglycerides - analysis ; Vertebrates: digestive system</subject><ispartof>British journal of nutrition, 2001-02, Vol.85 (2), p.165-172</ispartof><rights>Copyright © The Nutrition Society 2001</rights><rights>2001 INIST-CNRS</rights><rights>The Nutrition Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-8d52c1a1f70fe4cb684d339f2f2016deb6f1461cefd4a7006c6798ae198cd4cb3</citedby><cites>FETCH-LOGICAL-c449t-8d52c1a1f70fe4cb684d339f2f2016deb6f1461cefd4a7006c6798ae198cd4cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=907463$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11242484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramjiganesh, Tripurasundari</creatorcontrib><creatorcontrib>Roy, Suheeta</creatorcontrib><creatorcontrib>McIntyre, Jonathan C.</creatorcontrib><creatorcontrib>Luz Fernandez, Maria</creatorcontrib><title>The hypocholesterolaemic effects of sitostanol in the guinea pig are in part related to changes in hepatic lipids and lipoprotein composition</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>To evaluate some of the mechanisms involved in the plasma cholesterol lowering of sitostanol (SI), male Hartley guinea pigs were fed diets containing cholesterol (0.25 g/100 g) and four doses of SI: either 0 (control), 0.75, 1.5 or 2.25 g/100 g. In addition a negative control (-C) group with dietary cholesterol (0.04 g/100 g) was included. Corn oil was used as the source of fat and the contribution of fat energy was 35 %. Plasma total cholesterol was 43, 49 and 53 % (P<0.0001) lower after SI intake compared to the control. Plasma LDL concentrations were 47, 53 and 61 % lower with increasing doses of SI. In addition, intake of SI resulted in 26–42 % lower hepatic total cholesterol. Hepatic esterified cholesterol and triacylglycerols were 32–60 % and 55–61 % lower after SI intake. SI intake resulted in favourable plasma and hepatic cholesterol concentrations similar to those in guinea pigs fed low levels of dietary cholesterol (-C). The LDL obtained from the control group had a higher number of molecules of free and esterified cholesterol than the SI groups. SI intake resulted in 69–71 % higher cholesterol excretion compared to the control. SI treatment enhanced the total faecal neutral sterol excretion by 54–58 % compared to control and by 70–76 % compared to the (-C) group. These results suggest that SI might have its hypocholesterolaemic effect by reducing cholesterol absorption, which results in lower concentration of cholesterol in liver. This reduction in hepatic cholesterol might possibly alter hepatic cholesterol metabolism and affect lipoprotein concentration and composition.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cholesterol</subject><subject>Cholesterol - analysis</subject><subject>Cholesterol Esters - analysis</subject><subject>Cholesterol, LDL - blood</subject><subject>Cholesterol, LDL - chemistry</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Excretion</subject><subject>Feces - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guinea Pigs</subject><subject>Hepatic lipids</subject><subject>Hypolipidemic Agents - metabolism</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>Lipids</subject><subject>Liver - chemistry</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver. Bile. Biliary tracts</subject><subject>Male</subject><subject>Neutral sterols</subject><subject>Oils & fats</subject><subject>Sitostanol</subject><subject>Sitosterols - metabolism</subject><subject>Sitosterols - pharmacology</subject><subject>Swine</subject><subject>Triglycerides - analysis</subject><subject>Vertebrates: digestive system</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkcFu1DAQhiMEokvhwgMgCyQOiIDtOLZzpFW7gKoi1HK2vM5445LEwXYk-hC8M4426kqIk-2Zz__8o78oXhL8gWDRfDz7ek0xxpTxR8WGMFGXlHP6uNjkoigJYfVJ8SzGu_yUBDdPixNCKKNMsk3x57YD1N1P3nS-h5gg-F7D4AwCa8GkiLxF0SUfkx59j9yIUv6xn90IGk1uj3SApTrpkFCAXidoUfLIdHrcQ1xaHUw6ZcXeTa6NSI_tcvVT8Aly2_hh8nmE8-Pz4onVfYQX63la_Li8uD3_XF592345_3RVGsaaVMq2poZoYgW2wMyOS9ZWVWOppZjwFnbcEsaJAdsyLTDmhotGaiCNNG3mq9Pi7UE3e_g157XV4KKBvtcj-DkqgXktGy4z-Pof8M7PYczeFCWVrASnPEPvDpAJPsYAVk3BDTrcK4LVkpA6JpThV6vivBugPaJrJBl4swI6Gt3boEfj4gPXYJFVMlUeKJcz-_3Q1eGn4qISteLb7-pM3rAbur1Wi-r71aMedsG1ezhu8h-XfwGKcLbs</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Ramjiganesh, Tripurasundari</creator><creator>Roy, Suheeta</creator><creator>McIntyre, Jonathan C.</creator><creator>Luz Fernandez, Maria</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20010201</creationdate><title>The hypocholesterolaemic effects of sitostanol in the guinea pig are in part related to changes in hepatic lipids and lipoprotein composition</title><author>Ramjiganesh, Tripurasundari ; Roy, Suheeta ; McIntyre, Jonathan C. ; Luz Fernandez, Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-8d52c1a1f70fe4cb684d339f2f2016deb6f1461cefd4a7006c6798ae198cd4cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cholesterol</topic><topic>Cholesterol - analysis</topic><topic>Cholesterol Esters - analysis</topic><topic>Cholesterol, LDL - blood</topic><topic>Cholesterol, LDL - chemistry</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Excretion</topic><topic>Feces - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guinea Pigs</topic><topic>Hepatic lipids</topic><topic>Hypolipidemic Agents - metabolism</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>Lipids</topic><topic>Liver - chemistry</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver. Bile. Biliary tracts</topic><topic>Male</topic><topic>Neutral sterols</topic><topic>Oils & fats</topic><topic>Sitostanol</topic><topic>Sitosterols - metabolism</topic><topic>Sitosterols - pharmacology</topic><topic>Swine</topic><topic>Triglycerides - analysis</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramjiganesh, Tripurasundari</creatorcontrib><creatorcontrib>Roy, Suheeta</creatorcontrib><creatorcontrib>McIntyre, Jonathan C.</creatorcontrib><creatorcontrib>Luz Fernandez, Maria</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramjiganesh, Tripurasundari</au><au>Roy, Suheeta</au><au>McIntyre, Jonathan C.</au><au>Luz Fernandez, Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The hypocholesterolaemic effects of sitostanol in the guinea pig are in part related to changes in hepatic lipids and lipoprotein composition</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>85</volume><issue>2</issue><spage>165</spage><epage>172</epage><pages>165-172</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>To evaluate some of the mechanisms involved in the plasma cholesterol lowering of sitostanol (SI), male Hartley guinea pigs were fed diets containing cholesterol (0.25 g/100 g) and four doses of SI: either 0 (control), 0.75, 1.5 or 2.25 g/100 g. In addition a negative control (-C) group with dietary cholesterol (0.04 g/100 g) was included. Corn oil was used as the source of fat and the contribution of fat energy was 35 %. Plasma total cholesterol was 43, 49 and 53 % (P<0.0001) lower after SI intake compared to the control. Plasma LDL concentrations were 47, 53 and 61 % lower with increasing doses of SI. In addition, intake of SI resulted in 26–42 % lower hepatic total cholesterol. Hepatic esterified cholesterol and triacylglycerols were 32–60 % and 55–61 % lower after SI intake. SI intake resulted in favourable plasma and hepatic cholesterol concentrations similar to those in guinea pigs fed low levels of dietary cholesterol (-C). The LDL obtained from the control group had a higher number of molecules of free and esterified cholesterol than the SI groups. SI intake resulted in 69–71 % higher cholesterol excretion compared to the control. SI treatment enhanced the total faecal neutral sterol excretion by 54–58 % compared to control and by 70–76 % compared to the (-C) group. These results suggest that SI might have its hypocholesterolaemic effect by reducing cholesterol absorption, which results in lower concentration of cholesterol in liver. This reduction in hepatic cholesterol might possibly alter hepatic cholesterol metabolism and affect lipoprotein concentration and composition.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>11242484</pmid><doi>10.1079/BJN2000246</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis of Variance Animals Biological and medical sciences Cholesterol Cholesterol - analysis Cholesterol Esters - analysis Cholesterol, LDL - blood Cholesterol, LDL - chemistry Dietary Fats - administration & dosage Dose-Response Relationship, Drug Excretion Feces - chemistry Fundamental and applied biological sciences. Psychology Guinea Pigs Hepatic lipids Hypolipidemic Agents - metabolism Hypolipidemic Agents - pharmacology Lipids Liver - chemistry Liver - drug effects Liver - metabolism Liver. Bile. Biliary tracts Male Neutral sterols Oils & fats Sitostanol Sitosterols - metabolism Sitosterols - pharmacology Swine Triglycerides - analysis Vertebrates: digestive system |
| title | The hypocholesterolaemic effects of sitostanol in the guinea pig are in part related to changes in hepatic lipids and lipoprotein composition |
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