CD154 Variant Lacking Tumor Necrosis Factor Homologous Domain Inhibits Cell Surface Expression of Wild-type Protein

X-linked hyper-IgM (XHIM) syndrome is an immunological disorder resulting from mutations in the CD154 gene. Some mutations occur in splicing sites and result in transcripts encoding wild-type and mutant proteins. These mutants lack the tumor necrosis factor homologous (TNFH) domain and consequently...

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Veröffentlicht in:	The Journal of biological chemistry 2001-01, Vol.276 (3), p.1673-1676
Hauptverfasser:	Su, Lihe, Garber, Ellen A., Hsu, Yen-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	CD154 antigen CD40 Ligand - genetics CD40 Ligand - metabolism Cell Line Cell Membrane - metabolism Humans hyperimmunoglobulinemia Mutation Tumor Necrosis Factor-alpha - genetics X-linked hyper-IgM syndrome
Online-Zugang:	Volltext
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