Stress-induced hyperthermia: Effects of acute and repeated dosing of MPEP
The mGlu5 receptor antagonist 2-methyl-6-(phenylethylnyl)-pyridine (MPEP) is highly anxiolytic in rodent models of anxiety. Recent studies showed that MPEP remains effective in some models of anxiety after repeated treatment, but tolerance may develop in other models. To further evaluate anxiolytic...
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| Veröffentlicht in: | European journal of pharmacology 2007-07, Vol.568 (1), p.199-202 |
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| container_title | European journal of pharmacology |
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| creator | Nordquist, Rebecca E. Durkin, Sean Jaeschke, Georg Spooren, Will |
| description | The mGlu5 receptor antagonist 2-methyl-6-(phenylethylnyl)-pyridine (MPEP) is highly anxiolytic in rodent models of anxiety. Recent studies showed that MPEP remains effective in some models of anxiety after repeated treatment, but tolerance may develop in other models. To further evaluate anxiolytic properties of repeated MPEP, a single administration of 3, 10, or 30 mg/kg p.o. and repeated administration of 30 mg/kg p.o. was tested in the stress-induced hyperthermia model in mice. MPEP dose-dependently inhibited stress-induced hyperthermia when given acutely. MPEP remained equally active in reducing stress-induced hyperthermia after five daily treatments with 30 mg/kg, further validating MPEP as a potential anxiolytic for chronic use. |
| doi_str_mv | 10.1016/j.ejphar.2007.04.034 |
| format | Article |
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Recent studies showed that MPEP remains effective in some models of anxiety after repeated treatment, but tolerance may develop in other models. To further evaluate anxiolytic properties of repeated MPEP, a single administration of 3, 10, or 30 mg/kg p.o. and repeated administration of 30 mg/kg p.o. was tested in the stress-induced hyperthermia model in mice. MPEP dose-dependently inhibited stress-induced hyperthermia when given acutely. 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Drug treatments</subject><subject>Pyridines - administration & dosage</subject><subject>Receptor, Metabotropic Glutamate 5</subject><subject>Receptors, Metabotropic Glutamate - antagonists & inhibitors</subject><subject>Stress, Psychological - complications</subject><subject>Stress-induced hyperthermia</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJaLbb_oNSfEludkYftqweCiFsm8CGBNKehSyNulp2bVeyA_n30bILuXUuc5jnfRkeQr5SqCjQ5npb4XbcmFgxAFmBqICLD2RBW6lKkJSdkQUAFSVTSl2QTyltAaBWrP5ILqisuRScLcj98xQxpTL0brbois3riHHaYNwH871YeY92SsXgC2PnCQvTuyLiiGbKrBtS6P8ejg9Pq6fP5NybXcIvp70kf36uft_elevHX_e3N-vScgVTaamrZWcbiUyiR4mKgu3AS-E631JmpBF5WuuE8Nx3hqq2UYyZBjpOOedLcnXsHePwb8Y06X1IFnc70-MwJy2hqWUNIoPiCNo4pBTR6zGGvYmvmoI-KNRbfVSoDwo1CJ0V5ti3U__c7dG9h07OMnB5AkyyZuej6W1I71zbyka2TeZ-HDnMNl4CRp1swD5bDjFb1W4I___kDfPckFs</recordid><startdate>20070730</startdate><enddate>20070730</enddate><creator>Nordquist, Rebecca E.</creator><creator>Durkin, Sean</creator><creator>Jaeschke, Georg</creator><creator>Spooren, Will</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070730</creationdate><title>Stress-induced hyperthermia: Effects of acute and repeated dosing of MPEP</title><author>Nordquist, Rebecca E. ; Durkin, Sean ; Jaeschke, Georg ; Spooren, Will</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-c1d57bc67e27efe7e910cb0f74dbf812a7a44448cd44f3fba1986922a60b31333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Anti-Anxiety Agents - administration & dosage</topic><topic>Anxiety - drug therapy</topic><topic>Anxiety - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Chronic</topic><topic>Excitatory Amino Acid Antagonists - administration & dosage</topic><topic>Fever - drug therapy</topic><topic>Fever - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabotropic glutamate receptor</topic><topic>mGlu5</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyridines - administration & dosage</topic><topic>Receptor, Metabotropic Glutamate 5</topic><topic>Receptors, Metabotropic Glutamate - antagonists & inhibitors</topic><topic>Stress, Psychological - complications</topic><topic>Stress-induced hyperthermia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nordquist, Rebecca E.</creatorcontrib><creatorcontrib>Durkin, Sean</creatorcontrib><creatorcontrib>Jaeschke, Georg</creatorcontrib><creatorcontrib>Spooren, Will</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nordquist, Rebecca E.</au><au>Durkin, Sean</au><au>Jaeschke, Georg</au><au>Spooren, Will</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stress-induced hyperthermia: Effects of acute and repeated dosing of MPEP</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2007-07-30</date><risdate>2007</risdate><volume>568</volume><issue>1</issue><spage>199</spage><epage>202</epage><pages>199-202</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The mGlu5 receptor antagonist 2-methyl-6-(phenylethylnyl)-pyridine (MPEP) is highly anxiolytic in rodent models of anxiety. 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| subjects | Animals Anti-Anxiety Agents - administration & dosage Anxiety - drug therapy Anxiety - physiopathology Biological and medical sciences Chronic Excitatory Amino Acid Antagonists - administration & dosage Fever - drug therapy Fever - physiopathology Male Medical sciences Metabotropic glutamate receptor mGlu5 Mice Mice, Inbred Strains Pharmacology. Drug treatments Pyridines - administration & dosage Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate - antagonists & inhibitors Stress, Psychological - complications Stress-induced hyperthermia |
| title | Stress-induced hyperthermia: Effects of acute and repeated dosing of MPEP |
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