Lymphocyte predominance Hodgkin disease is characterized by recurrent genomic imbalances

Single-cell polymerase chain reaction (PCR) has been used as a tool to demonstrate clonality and B-cell origin of Reed-Sternberg (RS) cells in Hodgkin disease (HD). An analogous approach was used to investigate genomic imbalances in a (cyto)genetically poorly characterized subentity: lymphocyte pred...

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Veröffentlicht in:	Blood 2001-03, Vol.97 (6), p.1845-1853
Hauptverfasser:	Franke, Sabine, Wlodarska, Iwona, Maes, Brigitte, Vandenberghe, Peter, Delabie, Jan, Hagemeijer, Anne, De Wolf-Peeters, Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, CD20 B-Lymphocytes - immunology B-Lymphocytes - pathology Biological and medical sciences Cell Culture Techniques Child Chromosome Aberrations - diagnosis Chromosome Aberrations - genetics Chromosome Disorders Cytogenetic Analysis DNA-Binding Proteins - genetics Female Frozen Sections Hematologic and hematopoietic diseases Hodgkin Disease - etiology Hodgkin Disease - genetics Hodgkin Disease - pathology Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - pathology Lymphocytes Male Medical sciences Middle Aged Nucleic Acid Hybridization Polymerase Chain Reaction - methods Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-6 Reed-Sternberg Cells - immunology Reed-Sternberg Cells - pathology Transcription Factors - genetics
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