Expression of the RAI gene is conducive to apoptosis: Studies of induction and interference

The RAI gene is also known as iASPP and PPP1R13L. Recent investigations have shown that the region encompassing RAI is important for the development of cancer in young and middle-aged persons. It has been speculated that the RAI product induces apoptosis by blocking NF-κB or inhibits apoptosis by bl...

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Veröffentlicht in:	Experimental cell research 2007-07, Vol.313 (12), p.2611-2621
Hauptverfasser:	Laska, Magdalena J., Strandbygård, Dorthe, Kjeldgaard, Anette, Mains, Mette, Corydon, Thomas J., Memon, Ashfaque A., Sørensen, Boe S., Vogel, Ulla, Jensen, Uffe B., Nexø, Bjørn A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Cell Line Cellular biology Etoposide - pharmacology Etoposide VP-16 Flow Cytometry Gene expression Gene Expression Regulation - drug effects Gene RAI Herpes Simplex Virus Protein Vmw65 - pharmacology Humans Inhibitor drugs Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Lymphocytes Lymphocytes - drug effects Lymphocytes - metabolism Molecular biology NF-κB Repressor Proteins RNA Interference RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - metabolism Sulfasalazine - pharmacology Time Factors Transfection
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