Aminosuberoyl hydroxamic acids (ASHAs): A potent new class of HDAC inhibitors

Exploring branched substrate-like HDAC inhibitors, mimicking the peptide substrate, lead to a series of aminosuberoyl hydroxamic acids (ASHAs) with remarkable HDAC inhibitory activity. Histone deacetylase (HDAC) inhibitors that target Class I and Class II HDACs are currently in advanced clinical tri...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-07, Vol.17 (14), p.3969-3971
Hauptverfasser:	Belvedere, Sandro, Witter, David J., Yan, Jiaming, Secrist, J. Paul, Richon, Victoria, Miller, Thomas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer drug Antineoplastic agents Biological and medical sciences Enzyme Inhibitors - pharmacology General aspects HDAC HDAC inhibitor Histone deacetylase inhibitor Histone Deacetylase Inhibitors Hydroxamic acids Hydroxamic Acids - pharmacology Medical sciences Mice Mice, Nude Pharmacology. Drug treatments SAHA
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