Clinical characteristics and course of spinal cord involvement in Behçet's disease
Parenchymal neurological involvement in Behçet's disease (p‐NBD) usually presents with a brainstem syndrome; occasionally spinal cord may also be involved. Files of patients with Behçet's disease and spinal cord involvement were reviewed retrospectively, in comparison with other types of p...
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| Veröffentlicht in: | European journal of neurology 2007-07, Vol.14 (7), p.729-737 |
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| creator | Yesilot, N. Mutlu, M. Gungor, O. Baykal, B. Serdaroglu, P. Akman-Demir, G. |
| description | Parenchymal neurological involvement in Behçet's disease (p‐NBD) usually presents with a brainstem syndrome; occasionally spinal cord may also be involved. Files of patients with Behçet's disease and spinal cord involvement were reviewed retrospectively, in comparison with other types of p‐NBD. Amongst 216 patients with p‐NBD, 24 had spinal cord involvement (11%). Most commonly patients presented with sensory‐motor symptoms, sphincter and/or sexual dysfunction evolving over days. Four of 10 patients showed single or multiple cervical and/or dorsal lesions on spinal MRI's and one showed dorsal atrophy. Although the clinical picture was variable, it tended to be severe; seven cases had primary progressive course, 11 cases had a secondary progressive course after initial attack(s), four had attacks with severe residual sequela and two had improvement after attacks. After a median follow‐up period of 67 months, eight were independent and 14 were dead or dependent, whereas amongst the remaining patients with p‐NBD, 113 patients were independent and 56 patients were dead or dependent (P |
| doi_str_mv | 10.1111/j.1468-1331.2007.01754.x |
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Files of patients with Behçet's disease and spinal cord involvement were reviewed retrospectively, in comparison with other types of p‐NBD. Amongst 216 patients with p‐NBD, 24 had spinal cord involvement (11%). Most commonly patients presented with sensory‐motor symptoms, sphincter and/or sexual dysfunction evolving over days. Four of 10 patients showed single or multiple cervical and/or dorsal lesions on spinal MRI's and one showed dorsal atrophy. Although the clinical picture was variable, it tended to be severe; seven cases had primary progressive course, 11 cases had a secondary progressive course after initial attack(s), four had attacks with severe residual sequela and two had improvement after attacks. After a median follow‐up period of 67 months, eight were independent and 14 were dead or dependent, whereas amongst the remaining patients with p‐NBD, 113 patients were independent and 56 patients were dead or dependent (P < 0.05). Our study suggests that spinal cord involvement has even worse prognosis compared with other types of p‐NBD. Therefore, recognition of spinal cord involvement in Behçet's patients should prompt early vigorous treatment.</description><identifier>ISSN: 1351-5101</identifier><identifier>EISSN: 1468-1331</identifier><identifier>EISSN: 1471-0552</identifier><identifier>DOI: 10.1111/j.1468-1331.2007.01754.x</identifier><identifier>PMID: 17594327</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Atrophy ; Behcet Syndrome - complications ; Behcet Syndrome - drug therapy ; Behcet Syndrome - pathology ; Behçet's disease ; Child ; Cognition Disorders - etiology ; Cohort Studies ; Disease Progression ; Evoked Potentials, Somatosensory ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; paraparesis ; Paraparesis - etiology ; Sensation Disorders - etiology ; Sexual Dysfunction, Physiological - etiology ; Spinal Cord - pathology ; spinal cord involvement ; Urination Disorders - etiology</subject><ispartof>European journal of neurology, 2007-07, Vol.14 (7), p.729-737</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5024-ded1216727265699f049c109c735e8fabeaa4498da5e1c49f168638d8d1d41f43</citedby><cites>FETCH-LOGICAL-c5024-ded1216727265699f049c109c735e8fabeaa4498da5e1c49f168638d8d1d41f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1468-1331.2007.01754.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1468-1331.2007.01754.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17594327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yesilot, N.</creatorcontrib><creatorcontrib>Mutlu, M.</creatorcontrib><creatorcontrib>Gungor, O.</creatorcontrib><creatorcontrib>Baykal, B.</creatorcontrib><creatorcontrib>Serdaroglu, P.</creatorcontrib><creatorcontrib>Akman-Demir, G.</creatorcontrib><title>Clinical characteristics and course of spinal cord involvement in Behçet's disease</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Parenchymal neurological involvement in Behçet's disease (p‐NBD) usually presents with a brainstem syndrome; occasionally spinal cord may also be involved. Files of patients with Behçet's disease and spinal cord involvement were reviewed retrospectively, in comparison with other types of p‐NBD. Amongst 216 patients with p‐NBD, 24 had spinal cord involvement (11%). Most commonly patients presented with sensory‐motor symptoms, sphincter and/or sexual dysfunction evolving over days. Four of 10 patients showed single or multiple cervical and/or dorsal lesions on spinal MRI's and one showed dorsal atrophy. Although the clinical picture was variable, it tended to be severe; seven cases had primary progressive course, 11 cases had a secondary progressive course after initial attack(s), four had attacks with severe residual sequela and two had improvement after attacks. After a median follow‐up period of 67 months, eight were independent and 14 were dead or dependent, whereas amongst the remaining patients with p‐NBD, 113 patients were independent and 56 patients were dead or dependent (P < 0.05). Our study suggests that spinal cord involvement has even worse prognosis compared with other types of p‐NBD. Therefore, recognition of spinal cord involvement in Behçet's patients should prompt early vigorous treatment.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Atrophy</subject><subject>Behcet Syndrome - complications</subject><subject>Behcet Syndrome - drug therapy</subject><subject>Behcet Syndrome - pathology</subject><subject>Behçet's disease</subject><subject>Child</subject><subject>Cognition Disorders - etiology</subject><subject>Cohort Studies</subject><subject>Disease Progression</subject><subject>Evoked Potentials, Somatosensory</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>paraparesis</subject><subject>Paraparesis - etiology</subject><subject>Sensation Disorders - etiology</subject><subject>Sexual Dysfunction, Physiological - etiology</subject><subject>Spinal Cord - pathology</subject><subject>spinal cord involvement</subject><subject>Urination Disorders - etiology</subject><issn>1351-5101</issn><issn>1468-1331</issn><issn>1471-0552</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFO3DAURa2qVaHAL1RewSqpX2zHyYJFGQ1QiZlKhZalZewX4WkmGewMDF_UD-mP4XRGdNl64yf53GvrmBAKLIe0Pi1yEGWVAeeQF4ypnIGSIt-8IfuvB2_TzCVkEhjskQ8xLhhjhSrYe7KX6FrwQu2T60nrO29NS-29CcYOGHwcvI3UdI7afh0i0r6hceW7EeqDo7577NtHXGI3pJme4f3vXzicROp8RBPxkLxrTBvxaLcfkO_n05vJZXb19eLL5PNVZiUrRObQQQGlSm8qZVnXDRO1BVZbxSVWjblDY4SoK2ckghV1A2VV8spVDpyARvADcrztXYX-YY1x0EsfLbat6bBfR61Y6uWM_ROEWpSM87Gx2oI29DEGbPQq-KUJzxqYHs3rhR4F61GwHs3rP-b1JkU_7u5Y3y3R_Q3uVCfgdAs8-Raf_7tYT-fTcUr5bJtP_4Ob17wJP3WpuJL6dn6hL2cz-UN8m-sZfwGXQqEC</recordid><startdate>200707</startdate><enddate>200707</enddate><creator>Yesilot, N.</creator><creator>Mutlu, M.</creator><creator>Gungor, O.</creator><creator>Baykal, B.</creator><creator>Serdaroglu, P.</creator><creator>Akman-Demir, G.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200707</creationdate><title>Clinical characteristics and course of spinal cord involvement in Behçet's disease</title><author>Yesilot, N. ; Mutlu, M. ; Gungor, O. ; Baykal, B. ; Serdaroglu, P. ; Akman-Demir, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5024-ded1216727265699f049c109c735e8fabeaa4498da5e1c49f168638d8d1d41f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Atrophy</topic><topic>Behcet Syndrome - complications</topic><topic>Behcet Syndrome - drug therapy</topic><topic>Behcet Syndrome - pathology</topic><topic>Behçet's disease</topic><topic>Child</topic><topic>Cognition Disorders - etiology</topic><topic>Cohort Studies</topic><topic>Disease Progression</topic><topic>Evoked Potentials, Somatosensory</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>paraparesis</topic><topic>Paraparesis - etiology</topic><topic>Sensation Disorders - etiology</topic><topic>Sexual Dysfunction, Physiological - etiology</topic><topic>Spinal Cord - pathology</topic><topic>spinal cord involvement</topic><topic>Urination Disorders - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yesilot, N.</creatorcontrib><creatorcontrib>Mutlu, M.</creatorcontrib><creatorcontrib>Gungor, O.</creatorcontrib><creatorcontrib>Baykal, B.</creatorcontrib><creatorcontrib>Serdaroglu, P.</creatorcontrib><creatorcontrib>Akman-Demir, G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yesilot, N.</au><au>Mutlu, M.</au><au>Gungor, O.</au><au>Baykal, B.</au><au>Serdaroglu, P.</au><au>Akman-Demir, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics and course of spinal cord involvement in Behçet's disease</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2007-07</date><risdate>2007</risdate><volume>14</volume><issue>7</issue><spage>729</spage><epage>737</epage><pages>729-737</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><eissn>1471-0552</eissn><abstract>Parenchymal neurological involvement in Behçet's disease (p‐NBD) usually presents with a brainstem syndrome; occasionally spinal cord may also be involved. Files of patients with Behçet's disease and spinal cord involvement were reviewed retrospectively, in comparison with other types of p‐NBD. Amongst 216 patients with p‐NBD, 24 had spinal cord involvement (11%). Most commonly patients presented with sensory‐motor symptoms, sphincter and/or sexual dysfunction evolving over days. Four of 10 patients showed single or multiple cervical and/or dorsal lesions on spinal MRI's and one showed dorsal atrophy. Although the clinical picture was variable, it tended to be severe; seven cases had primary progressive course, 11 cases had a secondary progressive course after initial attack(s), four had attacks with severe residual sequela and two had improvement after attacks. After a median follow‐up period of 67 months, eight were independent and 14 were dead or dependent, whereas amongst the remaining patients with p‐NBD, 113 patients were independent and 56 patients were dead or dependent (P < 0.05). Our study suggests that spinal cord involvement has even worse prognosis compared with other types of p‐NBD. Therefore, recognition of spinal cord involvement in Behçet's patients should prompt early vigorous treatment.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17594327</pmid><doi>10.1111/j.1468-1331.2007.01754.x</doi><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Adult Atrophy Behcet Syndrome - complications Behcet Syndrome - drug therapy Behcet Syndrome - pathology Behçet's disease Child Cognition Disorders - etiology Cohort Studies Disease Progression Evoked Potentials, Somatosensory Female Humans Magnetic Resonance Imaging Male paraparesis Paraparesis - etiology Sensation Disorders - etiology Sexual Dysfunction, Physiological - etiology Spinal Cord - pathology spinal cord involvement Urination Disorders - etiology |
| title | Clinical characteristics and course of spinal cord involvement in Behçet's disease |
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