Cardiac complications of a dengue fever outbreak in Sri Lanka, 2005
A high incidence of cardiac complications was observed in an outbreak of dengue fever at General Hospital, Peradeniya, Sri Lanka, in 2005. This report describes 120 serologically confirmed dengue fever patients who presented during the outbreak. Seventy-five (62.5%) of these patients had electrocard...
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| Veröffentlicht in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 2007-08, Vol.101 (8), p.804-808 |
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| container_title | Transactions of the Royal Society of Tropical Medicine and Hygiene |
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| creator | Kularatne, S.A.M. Pathirage, M.M.K. Kumarasiri, P.V.R. Gunasena, S. Mahindawanse, S.I. |
| description | A high incidence of cardiac complications was observed in an outbreak of dengue fever at General Hospital, Peradeniya, Sri Lanka, in 2005. This report describes 120 serologically confirmed dengue fever patients who presented during the outbreak. Seventy-five (62.5%) of these patients had electrocardiogram changes (T inversion, ST depression, bundle branch blocks) and were assigned to the ‘cardiac group’ (50 females, 25 males; median age 34 years, range 13–76). These patients were more susceptible to fatigue, dyspnoea, low peripheral oxygen saturation in room air (
P
=
0.001), chest pain (
P
=
0.001) and flushing of skin (
P
=
0.05) than 45 (37.5%) patients who had normal electrocardiograms and made up the ‘non-cardiac group’. In the cardiac group there were 31 primary and 44 secondary dengue patients. In the cardiac group, 17 (23%) patients had hypotension and 58 (77%) developed tachycardia and bradycardia (
P
<
0.001) compared to four (9%) in the non-cardiac group, suggestive of significant cardiac dysfunction. There was no correlation between pulse rate and body temperature: cardiac group (
r
=
0.05;
P
=
0.63); non-cardiac group (
r
=
0.11,
P
=
0.46). RT-PCR detected DEN-3 in three cardiac patients. |
| doi_str_mv | 10.1016/j.trstmh.2007.02.021 |
| format | Article |
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P
=
0.001), chest pain (
P
=
0.001) and flushing of skin (
P
=
0.05) than 45 (37.5%) patients who had normal electrocardiograms and made up the ‘non-cardiac group’. In the cardiac group there were 31 primary and 44 secondary dengue patients. In the cardiac group, 17 (23%) patients had hypotension and 58 (77%) developed tachycardia and bradycardia (
P
<
0.001) compared to four (9%) in the non-cardiac group, suggestive of significant cardiac dysfunction. There was no correlation between pulse rate and body temperature: cardiac group (
r
=
0.05;
P
=
0.63); non-cardiac group (
r
=
0.11,
P
=
0.46). RT-PCR detected DEN-3 in three cardiac patients.</description><identifier>ISSN: 0035-9203</identifier><identifier>EISSN: 1878-3503</identifier><identifier>DOI: 10.1016/j.trstmh.2007.02.021</identifier><identifier>PMID: 17428513</identifier><identifier>CODEN: TRSTAZ</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Arboviroses ; Biological and medical sciences ; Bradycardia ; Cardiology. Vascular system ; Cardiomyopathies - diagnostic imaging ; Cardiomyopathies - virology ; DEN-3 ; Dengue - complications ; Dengue - epidemiology ; Dengue fever ; Dengue fevers ; Disease Outbreaks ; Electrocardiography ; Female ; Heart ; Heart Diseases - epidemiology ; Heart Diseases - virology ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Myocarditis ; Myocarditis. Cardiomyopathies ; Radiography ; Sri Lanka ; Sri Lanka - epidemiology ; Tachycardia ; Tropical viral diseases ; Viral diseases</subject><ispartof>Transactions of the Royal Society of Tropical Medicine and Hygiene, 2007-08, Vol.101 (8), p.804-808</ispartof><rights>2007 Royal Society of Tropical Medicine and Hygiene</rights><rights>Royal Society of Tropical Medicine and Hygiene 2007</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-791170f12cd74983962d4308ffbc05d11a5c5f43198a3608dd00ea430a87a5723</citedby><cites>FETCH-LOGICAL-c468t-791170f12cd74983962d4308ffbc05d11a5c5f43198a3608dd00ea430a87a5723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18890134$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17428513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kularatne, S.A.M.</creatorcontrib><creatorcontrib>Pathirage, M.M.K.</creatorcontrib><creatorcontrib>Kumarasiri, P.V.R.</creatorcontrib><creatorcontrib>Gunasena, S.</creatorcontrib><creatorcontrib>Mahindawanse, S.I.</creatorcontrib><title>Cardiac complications of a dengue fever outbreak in Sri Lanka, 2005</title><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><addtitle>Trans R Soc Trop Med Hyg</addtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><description>A high incidence of cardiac complications was observed in an outbreak of dengue fever at General Hospital, Peradeniya, Sri Lanka, in 2005. This report describes 120 serologically confirmed dengue fever patients who presented during the outbreak. Seventy-five (62.5%) of these patients had electrocardiogram changes (T inversion, ST depression, bundle branch blocks) and were assigned to the ‘cardiac group’ (50 females, 25 males; median age 34 years, range 13–76). These patients were more susceptible to fatigue, dyspnoea, low peripheral oxygen saturation in room air (
P
=
0.001), chest pain (
P
=
0.001) and flushing of skin (
P
=
0.05) than 45 (37.5%) patients who had normal electrocardiograms and made up the ‘non-cardiac group’. In the cardiac group there were 31 primary and 44 secondary dengue patients. In the cardiac group, 17 (23%) patients had hypotension and 58 (77%) developed tachycardia and bradycardia (
P
<
0.001) compared to four (9%) in the non-cardiac group, suggestive of significant cardiac dysfunction. There was no correlation between pulse rate and body temperature: cardiac group (
r
=
0.05;
P
=
0.63); non-cardiac group (
r
=
0.11,
P
=
0.46). RT-PCR detected DEN-3 in three cardiac patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Arboviroses</subject><subject>Biological and medical sciences</subject><subject>Bradycardia</subject><subject>Cardiology. Vascular system</subject><subject>Cardiomyopathies - diagnostic imaging</subject><subject>Cardiomyopathies - virology</subject><subject>DEN-3</subject><subject>Dengue - complications</subject><subject>Dengue - epidemiology</subject><subject>Dengue fever</subject><subject>Dengue fevers</subject><subject>Disease Outbreaks</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart</subject><subject>Heart Diseases - epidemiology</subject><subject>Heart Diseases - virology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocarditis</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Radiography</subject><subject>Sri Lanka</subject><subject>Sri Lanka - epidemiology</subject><subject>Tachycardia</subject><subject>Tropical viral diseases</subject><subject>Viral diseases</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1rFDEUhoModlv9ByK50Stne5JMJpkbQUZrhYVetIJ4E84mGc3ufKzJTKn_vimz2LsiHDg3z_u-8BDyhsGaAavOd-sppqn_veYAag08H3tGVkwrXQgJ4jlZAQhZ1BzECTlNaQfAJZP1S3LCVMm1ZGJFmgajC2ipHftDFyxOYRwSHVuK1Pnh1-xp6299pOM8baPHPQ0DvY6BbnDY4weax-Ur8qLFLvnXx39Gvl98uWkui83V12_Np01hy0pPhaoZU9Aybp0qay3qirtSgG7brQXpGENpZVsKVmsUFWjnADxmArVCqbg4I--X3kMc_8w-TaYPyfquw8GPczIKKim1lhksF9DGMaXoW3OIocf41zAwD_LMzizyzIM8Azwfy7G3x_5523v3GDraysC7I4DJYtdGHGxIj5zWNTBRZu584cb58L_TxZIIafJ3_zIY96ZSQklz-eOnueDqBj43YFTmPy68z75vg48m2eAH612I3k7GjeHpwXuDM6pW</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Kularatne, S.A.M.</creator><creator>Pathirage, M.M.K.</creator><creator>Kumarasiri, P.V.R.</creator><creator>Gunasena, S.</creator><creator>Mahindawanse, S.I.</creator><general>Elsevier Ltd</general><general>Royal Society of Tropical Medicine and Hygiene</general><general>Elsevier</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Cardiac complications of a dengue fever outbreak in Sri Lanka, 2005</title><author>Kularatne, S.A.M. ; Pathirage, M.M.K. ; Kumarasiri, P.V.R. ; Gunasena, S. ; Mahindawanse, S.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-791170f12cd74983962d4308ffbc05d11a5c5f43198a3608dd00ea430a87a5723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Arboviroses</topic><topic>Biological and medical sciences</topic><topic>Bradycardia</topic><topic>Cardiology. Vascular system</topic><topic>Cardiomyopathies - diagnostic imaging</topic><topic>Cardiomyopathies - virology</topic><topic>DEN-3</topic><topic>Dengue - complications</topic><topic>Dengue - epidemiology</topic><topic>Dengue fever</topic><topic>Dengue fevers</topic><topic>Disease Outbreaks</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart</topic><topic>Heart Diseases - epidemiology</topic><topic>Heart Diseases - virology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocarditis</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Radiography</topic><topic>Sri Lanka</topic><topic>Sri Lanka - epidemiology</topic><topic>Tachycardia</topic><topic>Tropical viral diseases</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kularatne, S.A.M.</creatorcontrib><creatorcontrib>Pathirage, M.M.K.</creatorcontrib><creatorcontrib>Kumarasiri, P.V.R.</creatorcontrib><creatorcontrib>Gunasena, S.</creatorcontrib><creatorcontrib>Mahindawanse, S.I.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kularatne, S.A.M.</au><au>Pathirage, M.M.K.</au><au>Kumarasiri, P.V.R.</au><au>Gunasena, S.</au><au>Mahindawanse, S.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac complications of a dengue fever outbreak in Sri Lanka, 2005</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><stitle>Trans R Soc Trop Med Hyg</stitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>101</volume><issue>8</issue><spage>804</spage><epage>808</epage><pages>804-808</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><coden>TRSTAZ</coden><abstract>A high incidence of cardiac complications was observed in an outbreak of dengue fever at General Hospital, Peradeniya, Sri Lanka, in 2005. This report describes 120 serologically confirmed dengue fever patients who presented during the outbreak. Seventy-five (62.5%) of these patients had electrocardiogram changes (T inversion, ST depression, bundle branch blocks) and were assigned to the ‘cardiac group’ (50 females, 25 males; median age 34 years, range 13–76). These patients were more susceptible to fatigue, dyspnoea, low peripheral oxygen saturation in room air (
P
=
0.001), chest pain (
P
=
0.001) and flushing of skin (
P
=
0.05) than 45 (37.5%) patients who had normal electrocardiograms and made up the ‘non-cardiac group’. In the cardiac group there were 31 primary and 44 secondary dengue patients. In the cardiac group, 17 (23%) patients had hypotension and 58 (77%) developed tachycardia and bradycardia (
P
<
0.001) compared to four (9%) in the non-cardiac group, suggestive of significant cardiac dysfunction. There was no correlation between pulse rate and body temperature: cardiac group (
r
=
0.05;
P
=
0.63); non-cardiac group (
r
=
0.11,
P
=
0.46). RT-PCR detected DEN-3 in three cardiac patients.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17428513</pmid><doi>10.1016/j.trstmh.2007.02.021</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene, 2007-08, Vol.101 (8), p.804-808 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adolescent Adult Aged Arboviroses Biological and medical sciences Bradycardia Cardiology. Vascular system Cardiomyopathies - diagnostic imaging Cardiomyopathies - virology DEN-3 Dengue - complications Dengue - epidemiology Dengue fever Dengue fevers Disease Outbreaks Electrocardiography Female Heart Heart Diseases - epidemiology Heart Diseases - virology Human viral diseases Humans Infectious diseases Male Medical sciences Middle Aged Myocarditis Myocarditis. Cardiomyopathies Radiography Sri Lanka Sri Lanka - epidemiology Tachycardia Tropical viral diseases Viral diseases |
| title | Cardiac complications of a dengue fever outbreak in Sri Lanka, 2005 |
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