MDM2 and MDMX can interact differently with ARF and members of the p53 family

Members of the p53 family of transcription factors have essential roles in tumor suppression and in development. MDM2 is an essential regulator of p53 that can inhibit the transcriptional activity of p53, shuttle p53 out of the nucleus, and target p53 for ubiquitination-mediated degradation. Little...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	FEBS letters 2001-02, Vol.490 (3), p.202-208
Hauptverfasser:	Wang, XiaoQi, Arooz, Talha, Siu, Wai Yi, Chiu, Clarissa H.S, Lau, Anita, Yamashita, Katsumi, Poon, Randy Y.C
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-Ribosylation Factors - metabolism ARF DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fluorescent Antibody Technique Gene Expression Regulation Genes, Tumor Suppressor Humans MDM2 MDMX Membrane Proteins Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - metabolism p53 p63 p73 Phosphoproteins - genetics Phosphoproteins - metabolism Protein Binding Protein Transport Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-mdm2 Recombinant Fusion Proteins Substrate Specificity Trans-Activators Transcription Factors Transcription, Genetic Transfection Tumor Cells, Cultured Tumor Protein p73 Tumor suppressor Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!