Fructose and the Metabolic Syndrome: Pathophysiology and Molecular Mechanisms
Emerging evidence suggests that increased dietary consumption of fructose in Western society may be a potentially important factor in the growing rates of obesity and the metabolic syndrome. This review will discuss fructose-induced perturbations in cell signaling and inflammatory cascades in insuli...
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| Veröffentlicht in: | Nutrition reviews 2007-06, Vol.65 (6), p.S13-S23 |
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| creator | Rutledge, A.C Adeli, K |
| description | Emerging evidence suggests that increased dietary consumption of fructose in Western society may be a potentially important factor in the growing rates of obesity and the metabolic syndrome. This review will discuss fructose-induced perturbations in cell signaling and inflammatory cascades in insulin-sensitive tissues. In particular, the roles of cellular signaling molecules including nuclear factor kappa B (NFkB), tumor necrosis factor alpha (TNF-α), c-Jun amino terminal kinase 1 (JNK-1), protein tyrosine phosphatase 1B (PTP-1B), phosphatase and tensin homolog deleted on chromosome ten (PTEN), liver X receptor (LXR), farnesoid X receptor (FXR), and sterol regulatory element-binding protein-1c (SREBP-1c) will be addressed. Considering the prevalence and seriousness of the metabolic syndrome, further research on the underlying molecular mechanisms and preventative and curative strategies is warranted. |
| doi_str_mv | 10.1111/j.1753-4887.2007.tb00322.x |
| format | Article |
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This review will discuss fructose-induced perturbations in cell signaling and inflammatory cascades in insulin-sensitive tissues. In particular, the roles of cellular signaling molecules including nuclear factor kappa B (NFkB), tumor necrosis factor alpha (TNF-α), c-Jun amino terminal kinase 1 (JNK-1), protein tyrosine phosphatase 1B (PTP-1B), phosphatase and tensin homolog deleted on chromosome ten (PTEN), liver X receptor (LXR), farnesoid X receptor (FXR), and sterol regulatory element-binding protein-1c (SREBP-1c) will be addressed. Considering the prevalence and seriousness of the metabolic syndrome, further research on the underlying molecular mechanisms and preventative and curative strategies is warranted.</description><identifier>ISSN: 0029-6643</identifier><identifier>EISSN: 1753-4887</identifier><identifier>DOI: 10.1111/j.1753-4887.2007.tb00322.x</identifier><identifier>PMID: 17605309</identifier><identifier>CODEN: NUREA8</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>adipose tissue ; animal disease models ; Animals ; Biological and medical sciences ; cell communication ; Diabetes ; Disease Models, Animal ; experimental diets ; fructose ; Fructose - administration & dosage ; gene expression regulation ; hepatic lipogenesis ; human nutrition ; Humans ; hyperlipidemia ; inflammation ; Insulin ; insulin resistance ; JNK ; lipogenesis ; literature reviews ; Medical sciences ; Metabolic diseases ; metabolic studies ; metabolic syndrome ; Metabolic Syndrome - etiology ; Metabolic Syndrome - metabolism ; Metabolism ; Miscellaneous ; molecular epidemiology ; NFkB ; Nutrition ; nutrition research ; obesity ; Obesity - etiology ; Obesity - metabolism ; Other metabolic disorders ; pathophysiology ; Rodents ; Signal Transduction - drug effects ; Sweetening Agents - administration & dosage ; TNF-α ; transcription factors</subject><ispartof>Nutrition reviews, 2007-06, Vol.65 (6), p.S13-S23</ispartof><rights>2007 INIST-CNRS</rights><rights>Copyright National Library of Medicine - MEDLINE Abstracts Jun 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5253-a2ac25399a16efa181cbcef5555c9d33722ec3c7bc0ce3588efb4e898e6fa34b3</citedby><cites>FETCH-LOGICAL-c5253-a2ac25399a16efa181cbcef5555c9d33722ec3c7bc0ce3588efb4e898e6fa34b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1753-4887.2007.tb00322.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1753-4887.2007.tb00322.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,1411,23909,23910,25118,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18910748$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17605309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rutledge, A.C</creatorcontrib><creatorcontrib>Adeli, K</creatorcontrib><title>Fructose and the Metabolic Syndrome: Pathophysiology and Molecular Mechanisms</title><title>Nutrition reviews</title><addtitle>Nutr Rev</addtitle><description>Emerging evidence suggests that increased dietary consumption of fructose in Western society may be a potentially important factor in the growing rates of obesity and the metabolic syndrome. This review will discuss fructose-induced perturbations in cell signaling and inflammatory cascades in insulin-sensitive tissues. In particular, the roles of cellular signaling molecules including nuclear factor kappa B (NFkB), tumor necrosis factor alpha (TNF-α), c-Jun amino terminal kinase 1 (JNK-1), protein tyrosine phosphatase 1B (PTP-1B), phosphatase and tensin homolog deleted on chromosome ten (PTEN), liver X receptor (LXR), farnesoid X receptor (FXR), and sterol regulatory element-binding protein-1c (SREBP-1c) will be addressed. Considering the prevalence and seriousness of the metabolic syndrome, further research on the underlying molecular mechanisms and preventative and curative strategies is warranted.</description><subject>adipose tissue</subject><subject>animal disease models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>cell communication</subject><subject>Diabetes</subject><subject>Disease Models, Animal</subject><subject>experimental diets</subject><subject>fructose</subject><subject>Fructose - administration & dosage</subject><subject>gene expression regulation</subject><subject>hepatic lipogenesis</subject><subject>human nutrition</subject><subject>Humans</subject><subject>hyperlipidemia</subject><subject>inflammation</subject><subject>Insulin</subject><subject>insulin resistance</subject><subject>JNK</subject><subject>lipogenesis</subject><subject>literature reviews</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>metabolic studies</subject><subject>metabolic syndrome</subject><subject>Metabolic Syndrome - etiology</subject><subject>Metabolic Syndrome - metabolism</subject><subject>Metabolism</subject><subject>Miscellaneous</subject><subject>molecular epidemiology</subject><subject>NFkB</subject><subject>Nutrition</subject><subject>nutrition research</subject><subject>obesity</subject><subject>Obesity - etiology</subject><subject>Obesity - metabolism</subject><subject>Other metabolic disorders</subject><subject>pathophysiology</subject><subject>Rodents</subject><subject>Signal Transduction - drug effects</subject><subject>Sweetening Agents - administration & dosage</subject><subject>TNF-α</subject><subject>transcription factors</subject><issn>0029-6643</issn><issn>1753-4887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqVkF9v0zAUxS0EYqXwFaCaBG8J_pPE9l4mVK0DaR2IUvXRctybNSWJi52I5tvjkGiTeOO-3Af_zvG5B6FLgmMS5uMxJjxlUSIEjynGPG5zjBml8fkZmj0-PUczjKmMsixhF-iV90eMMaGSvUQXhGc4ZVjO0HrlOtNaDwvd7BftARZraHVuq9IsNn2zd7aGq8U33R7s6dD70lb2of_Lrm0Fpqu0Cwpz0E3pa_8avSh05eHNtOdou7r5sfwc3X29_bL8dBeZlIZ4mmoTtpSaZFBoIojJDRRpGCP3jHFKwTDDc4MNsFQIKPIEhBSQFZolOZujD6PvydlfHfhW1aU3UFW6Adt5xXGWJizMHF3-Ax5t55qQTVFCGc0SjgN0NULGWe8dFOrkylq7XhGshsbVUQ21qqFWNTSupsbVOYjfTj90eQ37J-lUcQDeT4D2RleF040p_RMnJME8EYG7HrnfZQX9f0RQ99vvNxsyHBuNDqVv4fzooN1PlXHGU7W7v1W7jIvVbrdUw93vRr7QVukHF1JtNxQTFuwlT2TC_gCzvLZR</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>Rutledge, A.C</creator><creator>Adeli, K</creator><general>Blackwell Publishing Ltd</general><general>International Life Sciences Institute</general><general>Oxford University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>200706</creationdate><title>Fructose and the Metabolic Syndrome: Pathophysiology and Molecular Mechanisms</title><author>Rutledge, A.C ; Adeli, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5253-a2ac25399a16efa181cbcef5555c9d33722ec3c7bc0ce3588efb4e898e6fa34b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>adipose tissue</topic><topic>animal disease models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>cell communication</topic><topic>Diabetes</topic><topic>Disease Models, Animal</topic><topic>experimental diets</topic><topic>fructose</topic><topic>Fructose - administration & dosage</topic><topic>gene expression regulation</topic><topic>hepatic lipogenesis</topic><topic>human nutrition</topic><topic>Humans</topic><topic>hyperlipidemia</topic><topic>inflammation</topic><topic>Insulin</topic><topic>insulin resistance</topic><topic>JNK</topic><topic>lipogenesis</topic><topic>literature reviews</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>metabolic studies</topic><topic>metabolic syndrome</topic><topic>Metabolic Syndrome - etiology</topic><topic>Metabolic Syndrome - metabolism</topic><topic>Metabolism</topic><topic>Miscellaneous</topic><topic>molecular epidemiology</topic><topic>NFkB</topic><topic>Nutrition</topic><topic>nutrition research</topic><topic>obesity</topic><topic>Obesity - etiology</topic><topic>Obesity - metabolism</topic><topic>Other metabolic disorders</topic><topic>pathophysiology</topic><topic>Rodents</topic><topic>Signal Transduction - drug effects</topic><topic>Sweetening Agents - administration & dosage</topic><topic>TNF-α</topic><topic>transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rutledge, A.C</creatorcontrib><creatorcontrib>Adeli, K</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - 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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | adipose tissue animal disease models Animals Biological and medical sciences cell communication Diabetes Disease Models, Animal experimental diets fructose Fructose - administration & dosage gene expression regulation hepatic lipogenesis human nutrition Humans hyperlipidemia inflammation Insulin insulin resistance JNK lipogenesis literature reviews Medical sciences Metabolic diseases metabolic studies metabolic syndrome Metabolic Syndrome - etiology Metabolic Syndrome - metabolism Metabolism Miscellaneous molecular epidemiology NFkB Nutrition nutrition research obesity Obesity - etiology Obesity - metabolism Other metabolic disorders pathophysiology Rodents Signal Transduction - drug effects Sweetening Agents - administration & dosage TNF-α transcription factors |
| title | Fructose and the Metabolic Syndrome: Pathophysiology and Molecular Mechanisms |
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