Malic enzyme: the controlling activity for lipid production? Overexpression of malic enzyme in Mucor circinelloides leads to a 2.5-fold increase in lipid accumulation

Department of Biological Sciences, University of Hull, Hull HU6 7RX, UK Correspondence Colin Ratledge c.ratledge{at}hull.ac.uk Malic enzyme (ME; NADP + -dependent; EC 1 . 1 . 1 . 40) has been postulated to be the rate-limiting step for fatty acid biosynthesis in oleaginous fungi in which the extent...

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Veröffentlicht in:	Microbiology (Society for General Microbiology) 2007-07, Vol.153 (7), p.2013-2025
Hauptverfasser:	Zhang, Ying, Adams, Ian P, Ratledge, Colin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Fungal Lipid Metabolism Lipids Malate Dehydrogenase - genetics Malate Dehydrogenase - metabolism Malates - metabolism Microbiology Molecular Sequence Data Mortierella alpina Mucor - enzymology Mucor - growth & development Mucor - metabolism Mucor circinelloides
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