Transport of new non-cross-resistant antitumor compounds of the benzoperimidine family in multidrug resistant cells

Multidrug resistance (MDR) phenotype in mammalian cells is often correlated with overexpression of P-glycoprotein or multidrug resistance-associated protein (MRP1). Both proteins are energy-dependent drug efflux pumps that efficiently reduce the intracellular accumulation and hence the cytotoxicity...

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Veröffentlicht in:	European journal of pharmacology 2001-02, Vol.413 (2), p.131-141
Hauptverfasser:	Tkaczyk-Gobis, Katarzyna, Tarasiuk, Jolanta, Seksek, Olivier, Stefanska, Barbara, Borowski, Edward, Garnier-Suillerot, Arlette
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells - drug effects 3T3 Cells - metabolism Animals Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology ATP Binding Cassette Transporter, Subfamily B, Member 1 - drug effects ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Benzoperimidine Biological and medical sciences Cell Nucleus - metabolism Chemotherapy DNA - metabolism Doxorubicin - analogs & derivatives Doxorubicin - pharmacology Drug Resistance, Multiple - physiology Drug Screening Assays, Antitumor - methods Genes, MDR - drug effects Genes, MDR - physiology Humans K562 Cells - drug effects K562 Cells - metabolism Lysosomes - metabolism Medical sciences Mice MRP1 (multidrug resistance-associated protein) Multidrug resistance P-glycoprotein Pharmacology. Drug treatments Quinazolines - chemistry Quinazolines - metabolism
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