Bowline mediates association of the transcriptional corepressor XGrg-4 with Tbx6 during somitogenesis in Xenopus
Prior to the somite segmentation, the cells in the anterior presomitic mesoderm (PSM) express a set of genes that is required for defining the segmental border and polarity of the prospective somite. However, little is known how the expression of these genes is repressed upon segmentation. Here we r...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2007-08, Vol.359 (4), p.959-964 |
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| creator | Kondow, Akiko Hitachi, Keisuke Okabayashi, Koji Hayashi, Nobuhiro Asashima, Makoto |
| description | Prior to the somite segmentation, the cells in the anterior presomitic mesoderm (PSM) express a set of genes that is required for defining the segmental border and polarity of the prospective somite. However, little is known how the expression of these genes is repressed upon segmentation. Here we report that Bowline, an associate protein of the transcriptional corepressor XGrg-4, repressed Tbx6 dependent transcription of
Thylacine1 by mediating interaction of Tbx6 with XGrg-4 in
Xenopus laevis. In
bowline-deficient embryos, segmental border formation was disturbed, and expression of
Thylacine1,
X-Delta-2, and
bowline expanded anteriorly. Tbx6-dependent transcription of
Thylacine1 was suppressed by Bowline, together with XGrg-4. We also found that Bowline mediated the interaction of Tbx6 and XGrg-4. Based on our findings, we conclude that a part of the transcriptional repression at the anterior end of the PSM is caused by Bowline mediated transcriptional repression of Tbx6-dependent gene expression in
X. laevis. |
| doi_str_mv | 10.1016/j.bbrc.2007.05.211 |
| format | Article |
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Thylacine1 by mediating interaction of Tbx6 with XGrg-4 in
Xenopus laevis. In
bowline-deficient embryos, segmental border formation was disturbed, and expression of
Thylacine1,
X-Delta-2, and
bowline expanded anteriorly. Tbx6-dependent transcription of
Thylacine1 was suppressed by Bowline, together with XGrg-4. We also found that Bowline mediated the interaction of Tbx6 and XGrg-4. Based on our findings, we conclude that a part of the transcriptional repression at the anterior end of the PSM is caused by Bowline mediated transcriptional repression of Tbx6-dependent gene expression in
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Thylacine1 by mediating interaction of Tbx6 with XGrg-4 in
Xenopus laevis. In
bowline-deficient embryos, segmental border formation was disturbed, and expression of
Thylacine1,
X-Delta-2, and
bowline expanded anteriorly. Tbx6-dependent transcription of
Thylacine1 was suppressed by Bowline, together with XGrg-4. We also found that Bowline mediated the interaction of Tbx6 and XGrg-4. Based on our findings, we conclude that a part of the transcriptional repression at the anterior end of the PSM is caused by Bowline mediated transcriptional repression of Tbx6-dependent gene expression in
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However, little is known how the expression of these genes is repressed upon segmentation. Here we report that Bowline, an associate protein of the transcriptional corepressor XGrg-4, repressed Tbx6 dependent transcription of
Thylacine1 by mediating interaction of Tbx6 with XGrg-4 in
Xenopus laevis. In
bowline-deficient embryos, segmental border formation was disturbed, and expression of
Thylacine1,
X-Delta-2, and
bowline expanded anteriorly. Tbx6-dependent transcription of
Thylacine1 was suppressed by Bowline, together with XGrg-4. We also found that Bowline mediated the interaction of Tbx6 and XGrg-4. Based on our findings, we conclude that a part of the transcriptional repression at the anterior end of the PSM is caused by Bowline mediated transcriptional repression of Tbx6-dependent gene expression in
X. laevis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17577580</pmid><doi>10.1016/j.bbrc.2007.05.211</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Body Patterning - physiology Co-Repressor Proteins DNA-Binding Proteins - metabolism Gene Expression Regulation, Developmental - physiology Groucho/TLE Presomitic mesoderm Repressor Proteins - metabolism Ripply1 Somites - physiology T-Box Domain Proteins - metabolism Tbx6 Thylacine1 Transcriptional Activation - physiology Xenopus laevis Xenopus laevis - embryology Xenopus laevis - physiology Xenopus Proteins - metabolism XGrg-4 |
| title | Bowline mediates association of the transcriptional corepressor XGrg-4 with Tbx6 during somitogenesis in Xenopus |
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