An oral adsorbent ameliorates renal overload of indoxyl sulfate and progression of renal failure in diabetic rats

Otsuka Long-Evans Tokushima Fatty (OLETF) rats were established as a new model of non–insulin-dependent diabetes mellitus. An oral adsorbent, AST-120, is effective in removing such uremic toxins as indoxyl sulfate and delays the progression of chronic renal failure (CRF). This study was designed to...

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Veröffentlicht in:	American journal of kidney diseases 2001-01, Vol.37 (1), p.S7-S12
Hauptverfasser:	Aoyama, Isao, Niwa, Toshimitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Associated diseases and complications Biological and medical sciences Blood Urea Nitrogen Carbon - pharmacology Cholesterol - blood Creatinine - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Diabetic Nephropathies - etiology Diabetic Nephropathies - metabolism Diabetic Nephropathies - prevention & control diabetic nephropathy Disease Progression Endocrine pancreas. Apud cells (diseases) Endocrinopathies Immunohistochemistry Indican - metabolism indoxyl sulfate Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - prevention & control Kidney Glomerulus - drug effects Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Kidneys Male Medical sciences Nephrology. Urinary tract diseases Oral adsorbent, AST-120 Otsuka Long-Evans Tokushima Fatty (OLETF) rats Oxides - pharmacology Rats Rats, Inbred OLETF Rats, Long-Evans Treatment Outcome Triglycerides - blood Urinary system involvement in other diseases. Miscellaneous
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