Expression of estrogen receptor-alpha protein in the rat digestive tract
The current study evaluates the expression of estrogen receptor-alpha (ER-alpha) protein in the digestive tract and other organs using immunohistochemistry in male and female intact rats. As a result, the expression of ER-alpha protein was intensively immunoreactive in the nuclei of squamous epithel...
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| Veröffentlicht in: | In vivo (Athens) 2007-05, Vol.21 (3), p.487-492 |
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| container_title | In vivo (Athens) |
| container_volume | 21 |
| creator | Gejima, Kentaro Kawaguchi, Hiroaki Souda, Masakazu Kawashima, Hideo Komokata, Teruo Hamada, Nobuo Umekita, Yoshihisa Sakata, Ryuzo Yoshida, Hiroki |
| description | The current study evaluates the expression of estrogen receptor-alpha (ER-alpha) protein in the digestive tract and other organs using immunohistochemistry in male and female intact rats. As a result, the expression of ER-alpha protein was intensively immunoreactive in the nuclei of squamous epithelium of the forestomach connected to the limiting ridge and the anus connected to the anorectal junction. Rat ER-alpha mRNA signals were also detected in the epithelium of the limiting ridge using in situ hybridization. The incidence of ER-alpha protein in the limiting ridge decreased with age in both males and females. The incidence of ER-alpha protein in the anorectal junction strongly decreased with age in males, although the incidence did not decrease with age in females. In conclusion, it was suggested that estrogen may be involved in the proliferation and differentiation of these cells in the limiting ridge of the stomach and anorectal junction of rats. |
| format | Article |
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As a result, the expression of ER-alpha protein was intensively immunoreactive in the nuclei of squamous epithelium of the forestomach connected to the limiting ridge and the anus connected to the anorectal junction. Rat ER-alpha mRNA signals were also detected in the epithelium of the limiting ridge using in situ hybridization. The incidence of ER-alpha protein in the limiting ridge decreased with age in both males and females. The incidence of ER-alpha protein in the anorectal junction strongly decreased with age in males, although the incidence did not decrease with age in females. In conclusion, it was suggested that estrogen may be involved in the proliferation and differentiation of these cells in the limiting ridge of the stomach and anorectal junction of rats.</description><identifier>ISSN: 0258-851X</identifier><identifier>PMID: 17591358</identifier><language>eng</language><publisher>Greece</publisher><subject>Age Factors ; Anal Canal - cytology ; Anal Canal - metabolism ; Animals ; Cardia - cytology ; Cardia - metabolism ; Cell Nucleus - metabolism ; Epithelial Cells - metabolism ; ERRalpha Estrogen-Related Receptor ; Female ; Gastrointestinal Tract - metabolism ; Gene Expression Regulation ; Immunoenzyme Techniques ; In Situ Hybridization ; Male ; Rats ; Rats, Sprague-Dawley ; Receptors, Estrogen - genetics ; Receptors, Estrogen - metabolism ; RNA, Messenger - metabolism ; Tissue Array Analysis</subject><ispartof>In vivo (Athens), 2007-05, Vol.21 (3), p.487-492</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17591358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gejima, Kentaro</creatorcontrib><creatorcontrib>Kawaguchi, Hiroaki</creatorcontrib><creatorcontrib>Souda, Masakazu</creatorcontrib><creatorcontrib>Kawashima, Hideo</creatorcontrib><creatorcontrib>Komokata, Teruo</creatorcontrib><creatorcontrib>Hamada, Nobuo</creatorcontrib><creatorcontrib>Umekita, Yoshihisa</creatorcontrib><creatorcontrib>Sakata, Ryuzo</creatorcontrib><creatorcontrib>Yoshida, Hiroki</creatorcontrib><title>Expression of estrogen receptor-alpha protein in the rat digestive tract</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>The current study evaluates the expression of estrogen receptor-alpha (ER-alpha) protein in the digestive tract and other organs using immunohistochemistry in male and female intact rats. As a result, the expression of ER-alpha protein was intensively immunoreactive in the nuclei of squamous epithelium of the forestomach connected to the limiting ridge and the anus connected to the anorectal junction. Rat ER-alpha mRNA signals were also detected in the epithelium of the limiting ridge using in situ hybridization. The incidence of ER-alpha protein in the limiting ridge decreased with age in both males and females. The incidence of ER-alpha protein in the anorectal junction strongly decreased with age in males, although the incidence did not decrease with age in females. In conclusion, it was suggested that estrogen may be involved in the proliferation and differentiation of these cells in the limiting ridge of the stomach and anorectal junction of rats.</description><subject>Age Factors</subject><subject>Anal Canal - cytology</subject><subject>Anal Canal - metabolism</subject><subject>Animals</subject><subject>Cardia - cytology</subject><subject>Cardia - metabolism</subject><subject>Cell Nucleus - metabolism</subject><subject>Epithelial Cells - metabolism</subject><subject>ERRalpha Estrogen-Related Receptor</subject><subject>Female</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Immunoenzyme Techniques</subject><subject>In Situ Hybridization</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Estrogen - genetics</subject><subject>Receptors, Estrogen - metabolism</subject><subject>RNA, Messenger - metabolism</subject><subject>Tissue Array Analysis</subject><issn>0258-851X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j81KxDAYRbNQnHH0FSQrd4UkTdpkKcPoCANuFNyV_HydibRNTFLRt7fgCBfu5nA59wKtCROykoK-r9B1zh-ENC0h7AqtaCsUrYVco_3uOybI2YcJhx5DLikcYcIJLMQSUqWHeNI4plDAT3hJOQFOumDnjwvtvwCXpG25QZe9HjLcnnuD3h53r9t9dXh5et4-HKrIiCrVIuBUzwWRzBjRA2ecgBaOE8pao21DeUM4NL2kwvDWklpZJyhQ6pi0ytQbdP-3uyh9zotBN_psYRj0BGHOXUsaLrniC3h3Bmczguti8qNOP93_9_oX-RdUpQ</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Gejima, Kentaro</creator><creator>Kawaguchi, Hiroaki</creator><creator>Souda, Masakazu</creator><creator>Kawashima, Hideo</creator><creator>Komokata, Teruo</creator><creator>Hamada, Nobuo</creator><creator>Umekita, Yoshihisa</creator><creator>Sakata, Ryuzo</creator><creator>Yoshida, Hiroki</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Expression of estrogen receptor-alpha protein in the rat digestive tract</title><author>Gejima, Kentaro ; Kawaguchi, Hiroaki ; Souda, Masakazu ; Kawashima, Hideo ; Komokata, Teruo ; Hamada, Nobuo ; Umekita, Yoshihisa ; Sakata, Ryuzo ; Yoshida, Hiroki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-700d9f45082bb5fe4240ea5d40127bac614604e6f815b47c039cd51e11d28c9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Age Factors</topic><topic>Anal Canal - cytology</topic><topic>Anal Canal - metabolism</topic><topic>Animals</topic><topic>Cardia - cytology</topic><topic>Cardia - metabolism</topic><topic>Cell Nucleus - metabolism</topic><topic>Epithelial Cells - metabolism</topic><topic>ERRalpha Estrogen-Related Receptor</topic><topic>Female</topic><topic>Gastrointestinal Tract - metabolism</topic><topic>Gene Expression Regulation</topic><topic>Immunoenzyme Techniques</topic><topic>In Situ Hybridization</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Estrogen - genetics</topic><topic>Receptors, Estrogen - metabolism</topic><topic>RNA, Messenger - metabolism</topic><topic>Tissue Array Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gejima, Kentaro</creatorcontrib><creatorcontrib>Kawaguchi, Hiroaki</creatorcontrib><creatorcontrib>Souda, Masakazu</creatorcontrib><creatorcontrib>Kawashima, Hideo</creatorcontrib><creatorcontrib>Komokata, Teruo</creatorcontrib><creatorcontrib>Hamada, Nobuo</creatorcontrib><creatorcontrib>Umekita, Yoshihisa</creatorcontrib><creatorcontrib>Sakata, Ryuzo</creatorcontrib><creatorcontrib>Yoshida, Hiroki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gejima, Kentaro</au><au>Kawaguchi, Hiroaki</au><au>Souda, Masakazu</au><au>Kawashima, Hideo</au><au>Komokata, Teruo</au><au>Hamada, Nobuo</au><au>Umekita, Yoshihisa</au><au>Sakata, Ryuzo</au><au>Yoshida, Hiroki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of estrogen receptor-alpha protein in the rat digestive tract</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>21</volume><issue>3</issue><spage>487</spage><epage>492</epage><pages>487-492</pages><issn>0258-851X</issn><abstract>The current study evaluates the expression of estrogen receptor-alpha (ER-alpha) protein in the digestive tract and other organs using immunohistochemistry in male and female intact rats. As a result, the expression of ER-alpha protein was intensively immunoreactive in the nuclei of squamous epithelium of the forestomach connected to the limiting ridge and the anus connected to the anorectal junction. Rat ER-alpha mRNA signals were also detected in the epithelium of the limiting ridge using in situ hybridization. The incidence of ER-alpha protein in the limiting ridge decreased with age in both males and females. The incidence of ER-alpha protein in the anorectal junction strongly decreased with age in males, although the incidence did not decrease with age in females. In conclusion, it was suggested that estrogen may be involved in the proliferation and differentiation of these cells in the limiting ridge of the stomach and anorectal junction of rats.</abstract><cop>Greece</cop><pmid>17591358</pmid><tpages>6</tpages></addata></record> |
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| ispartof | In vivo (Athens), 2007-05, Vol.21 (3), p.487-492 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Age Factors Anal Canal - cytology Anal Canal - metabolism Animals Cardia - cytology Cardia - metabolism Cell Nucleus - metabolism Epithelial Cells - metabolism ERRalpha Estrogen-Related Receptor Female Gastrointestinal Tract - metabolism Gene Expression Regulation Immunoenzyme Techniques In Situ Hybridization Male Rats Rats, Sprague-Dawley Receptors, Estrogen - genetics Receptors, Estrogen - metabolism RNA, Messenger - metabolism Tissue Array Analysis |
| title | Expression of estrogen receptor-alpha protein in the rat digestive tract |
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