Volume expansion potentiates cardiac sympathetic afferent reflex in dogs
Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, Nebraska 68198-4575 Our previous study (27) showed that the cardiac sympathetic afferent reflex (CSAR) was enhanced in dogs with congestive heart failure. The aim of this study was to test whether blood volum...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2001-02, Vol.280 (2), p.H576-H581 |
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| container_title | American journal of physiology. Heart and circulatory physiology |
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| creator | Wang, Wei Schultz, Harold D Ma, Rong |
| description | Department of Physiology and Biophysics, University of Nebraska
College of Medicine, Omaha, Nebraska 68198-4575
Our previous study (27) showed that the
cardiac sympathetic afferent reflex (CSAR) was enhanced in dogs with
congestive heart failure. The aim of this study was to test whether
blood volume expansion, which is one characteristic of congestive heart
failure, potentiates the CSAR in normal dogs. Ten dogs were studied
with sino-aortic denervation and bilateral cervical vagotomy. Arterial pressure, left ventricular pressure, left ventricular epicardial diameter, heart rate, and renal sympathetic nerve activity were measured. Coronary blood flow was also measured and, depending on the
experimental procedure, controlled. Blood volume expansion was carried
out by infusion of isosmotic dextran into a femoral vein at 40 ml/kg at
a rate of 50 ml/min. CSAR was elicited by application of bradykinin (5 and 50 µg) and capsaicin (10 and 100 µg) to the epicardial surface
of the left ventricle. Volume expansion increased arterial pressure,
left ventricular pressure, left ventricular diameter, and coronary
blood flow. Volume expansion without controlled coronary blood flow
only enhanced the RSNA response to the high dose (50 µg) of
epicardial bradykinin (17. 3 ± 1.9 vs. 10.6 ± 4.8%,
P |
| doi_str_mv | 10.1152/ajpheart.2001.280.2.h576 |
| format | Article |
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College of Medicine, Omaha, Nebraska 68198-4575
Our previous study (27) showed that the
cardiac sympathetic afferent reflex (CSAR) was enhanced in dogs with
congestive heart failure. The aim of this study was to test whether
blood volume expansion, which is one characteristic of congestive heart
failure, potentiates the CSAR in normal dogs. Ten dogs were studied
with sino-aortic denervation and bilateral cervical vagotomy. Arterial pressure, left ventricular pressure, left ventricular epicardial diameter, heart rate, and renal sympathetic nerve activity were measured. Coronary blood flow was also measured and, depending on the
experimental procedure, controlled. Blood volume expansion was carried
out by infusion of isosmotic dextran into a femoral vein at 40 ml/kg at
a rate of 50 ml/min. CSAR was elicited by application of bradykinin (5 and 50 µg) and capsaicin (10 and 100 µg) to the epicardial surface
of the left ventricle. Volume expansion increased arterial pressure,
left ventricular pressure, left ventricular diameter, and coronary
blood flow. Volume expansion without controlled coronary blood flow
only enhanced the RSNA response to the high dose (50 µg) of
epicardial bradykinin (17. 3 ± 1.9 vs. 10.6 ± 4.8%,
P < 0.05). However, volume expansion significantly
enhanced the RSNA responses to all doses of bradykinin and capsaicin
when coronary blood flow was held at the prevolume expansion level. The
RSNA responses to bradykinin (16. 9 ± 4.1 vs. 5.0 ± 1.3% for 5 µg, P < 0.05, and 28.9 ± 3.7 vs.
10.6 ± 4.8% for 50 µg, P < 0.05) and
capsaicin (29.8 ± 6.0 vs. 9.3 ± 3.1% for 10 µg,
P < 0.05, and 34.2 ± 2.7 vs. 15.1 ± 2.7%
for 100 µg, P < 0.05) were significantly augmented.
These results indicate that acute volume expansion potentiated the
CSAR. These data suggest that enhancement of the CSAR in congestive
heart failure may be mediated by the concomitant cardiac dilation,
which accompanies this disease state.
oxygen consumption; renal sympathetic nerve activity; bradykinin; capsaicin; dog; coronary blood flow</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.2001.280.2.h576</identifier><identifier>PMID: 11158954</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Bradykinin - pharmacology ; Capsaicin - pharmacology ; Cardiac Volume - physiology ; Coronary Circulation - drug effects ; Coronary Circulation - physiology ; Dogs ; Female ; Heart Failure - physiopathology ; Kidney - innervation ; Male ; Neurons, Afferent - physiology ; Oxygen Consumption - physiology ; Plasma Substitutes - pharmacology ; Plasma Volume - physiology ; Reflex - drug effects ; Reflex - physiology ; Sympathetic Nervous System - cytology ; Sympathetic Nervous System - physiology ; Ventricular Pressure - drug effects ; Ventricular Pressure - physiology</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2001-02, Vol.280 (2), p.H576-H581</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-fc9ee97f74fd75cb45ae4df9c7a35066d0119b45ac604608e6b582a2a0a3b6393</citedby><cites>FETCH-LOGICAL-c493t-fc9ee97f74fd75cb45ae4df9c7a35066d0119b45ac604608e6b582a2a0a3b6393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3026,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11158954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Schultz, Harold D</creatorcontrib><creatorcontrib>Ma, Rong</creatorcontrib><title>Volume expansion potentiates cardiac sympathetic afferent reflex in dogs</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description>Department of Physiology and Biophysics, University of Nebraska
College of Medicine, Omaha, Nebraska 68198-4575
Our previous study (27) showed that the
cardiac sympathetic afferent reflex (CSAR) was enhanced in dogs with
congestive heart failure. The aim of this study was to test whether
blood volume expansion, which is one characteristic of congestive heart
failure, potentiates the CSAR in normal dogs. Ten dogs were studied
with sino-aortic denervation and bilateral cervical vagotomy. Arterial pressure, left ventricular pressure, left ventricular epicardial diameter, heart rate, and renal sympathetic nerve activity were measured. Coronary blood flow was also measured and, depending on the
experimental procedure, controlled. Blood volume expansion was carried
out by infusion of isosmotic dextran into a femoral vein at 40 ml/kg at
a rate of 50 ml/min. CSAR was elicited by application of bradykinin (5 and 50 µg) and capsaicin (10 and 100 µg) to the epicardial surface
of the left ventricle. Volume expansion increased arterial pressure,
left ventricular pressure, left ventricular diameter, and coronary
blood flow. Volume expansion without controlled coronary blood flow
only enhanced the RSNA response to the high dose (50 µg) of
epicardial bradykinin (17. 3 ± 1.9 vs. 10.6 ± 4.8%,
P < 0.05). However, volume expansion significantly
enhanced the RSNA responses to all doses of bradykinin and capsaicin
when coronary blood flow was held at the prevolume expansion level. The
RSNA responses to bradykinin (16. 9 ± 4.1 vs. 5.0 ± 1.3% for 5 µg, P < 0.05, and 28.9 ± 3.7 vs.
10.6 ± 4.8% for 50 µg, P < 0.05) and
capsaicin (29.8 ± 6.0 vs. 9.3 ± 3.1% for 10 µg,
P < 0.05, and 34.2 ± 2.7 vs. 15.1 ± 2.7%
for 100 µg, P < 0.05) were significantly augmented.
These results indicate that acute volume expansion potentiated the
CSAR. These data suggest that enhancement of the CSAR in congestive
heart failure may be mediated by the concomitant cardiac dilation,
which accompanies this disease state.
oxygen consumption; renal sympathetic nerve activity; bradykinin; capsaicin; dog; coronary blood flow</description><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Bradykinin - pharmacology</subject><subject>Capsaicin - pharmacology</subject><subject>Cardiac Volume - physiology</subject><subject>Coronary Circulation - drug effects</subject><subject>Coronary Circulation - physiology</subject><subject>Dogs</subject><subject>Female</subject><subject>Heart Failure - physiopathology</subject><subject>Kidney - innervation</subject><subject>Male</subject><subject>Neurons, Afferent - physiology</subject><subject>Oxygen Consumption - physiology</subject><subject>Plasma Substitutes - pharmacology</subject><subject>Plasma Volume - physiology</subject><subject>Reflex - drug effects</subject><subject>Reflex - physiology</subject><subject>Sympathetic Nervous System - cytology</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Ventricular Pressure - drug effects</subject><subject>Ventricular Pressure - physiology</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE9PwyAchonR6Jx-BcPJWyuUQltvxqgzMfGiXgmjP1ZM_wk0bt9elk138kQCz_vy5kEIU5JSyrMb9Tk2oFxIM0JompUkzdKGF-IIzeJzllDOqmM0I0ywRFDGz9C595-EkMiwU3RGY0tZ8XyGFh9DO3WAYT2q3tuhx-MQoA9WBfBYK1dbpbHfdKMKDQSrsTIGXCSwA9PCGtse18PKX6ATo1oPl_tzjt4fH97uF8nL69Pz_d1LovOKhcToCqAqTJGbuuB6mXMFeW0qXSjGiRA1obTa3mpBckFKEEteZipTRLGlYBWbo-td7-iGrwl8kJ31GtpW9TBMXhZE5GVOaATLHajd4H0cK0dnO-U2khK5tSh_LcqtRRktykwutobm6Gr_x7TsoD4E99oicLsDGrtqvq0DOTabaK8dVhv5OLXtG6zDX_-hWY61ieH0__Bh02HOD3wrl-s</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Wang, Wei</creator><creator>Schultz, Harold D</creator><creator>Ma, Rong</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010201</creationdate><title>Volume expansion potentiates cardiac sympathetic afferent reflex in dogs</title><author>Wang, Wei ; Schultz, Harold D ; Ma, Rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-fc9ee97f74fd75cb45ae4df9c7a35066d0119b45ac604608e6b582a2a0a3b6393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Bradykinin - pharmacology</topic><topic>Capsaicin - pharmacology</topic><topic>Cardiac Volume - physiology</topic><topic>Coronary Circulation - drug effects</topic><topic>Coronary Circulation - physiology</topic><topic>Dogs</topic><topic>Female</topic><topic>Heart Failure - physiopathology</topic><topic>Kidney - innervation</topic><topic>Male</topic><topic>Neurons, Afferent - physiology</topic><topic>Oxygen Consumption - physiology</topic><topic>Plasma Substitutes - pharmacology</topic><topic>Plasma Volume - physiology</topic><topic>Reflex - drug effects</topic><topic>Reflex - physiology</topic><topic>Sympathetic Nervous System - cytology</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Ventricular Pressure - drug effects</topic><topic>Ventricular Pressure - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Schultz, Harold D</creatorcontrib><creatorcontrib>Ma, Rong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Wei</au><au>Schultz, Harold D</au><au>Ma, Rong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Volume expansion potentiates cardiac sympathetic afferent reflex in dogs</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>280</volume><issue>2</issue><spage>H576</spage><epage>H581</epage><pages>H576-H581</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><abstract>Department of Physiology and Biophysics, University of Nebraska
College of Medicine, Omaha, Nebraska 68198-4575
Our previous study (27) showed that the
cardiac sympathetic afferent reflex (CSAR) was enhanced in dogs with
congestive heart failure. The aim of this study was to test whether
blood volume expansion, which is one characteristic of congestive heart
failure, potentiates the CSAR in normal dogs. Ten dogs were studied
with sino-aortic denervation and bilateral cervical vagotomy. Arterial pressure, left ventricular pressure, left ventricular epicardial diameter, heart rate, and renal sympathetic nerve activity were measured. Coronary blood flow was also measured and, depending on the
experimental procedure, controlled. Blood volume expansion was carried
out by infusion of isosmotic dextran into a femoral vein at 40 ml/kg at
a rate of 50 ml/min. CSAR was elicited by application of bradykinin (5 and 50 µg) and capsaicin (10 and 100 µg) to the epicardial surface
of the left ventricle. Volume expansion increased arterial pressure,
left ventricular pressure, left ventricular diameter, and coronary
blood flow. Volume expansion without controlled coronary blood flow
only enhanced the RSNA response to the high dose (50 µg) of
epicardial bradykinin (17. 3 ± 1.9 vs. 10.6 ± 4.8%,
P < 0.05). However, volume expansion significantly
enhanced the RSNA responses to all doses of bradykinin and capsaicin
when coronary blood flow was held at the prevolume expansion level. The
RSNA responses to bradykinin (16. 9 ± 4.1 vs. 5.0 ± 1.3% for 5 µg, P < 0.05, and 28.9 ± 3.7 vs.
10.6 ± 4.8% for 50 µg, P < 0.05) and
capsaicin (29.8 ± 6.0 vs. 9.3 ± 3.1% for 10 µg,
P < 0.05, and 34.2 ± 2.7 vs. 15.1 ± 2.7%
for 100 µg, P < 0.05) were significantly augmented.
These results indicate that acute volume expansion potentiated the
CSAR. These data suggest that enhancement of the CSAR in congestive
heart failure may be mediated by the concomitant cardiac dilation,
which accompanies this disease state.
oxygen consumption; renal sympathetic nerve activity; bradykinin; capsaicin; dog; coronary blood flow</abstract><cop>United States</cop><pmid>11158954</pmid><doi>10.1152/ajpheart.2001.280.2.h576</doi></addata></record> |
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| ispartof | American journal of physiology. Heart and circulatory physiology, 2001-02, Vol.280 (2), p.H576-H581 |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Blood Pressure - drug effects Blood Pressure - physiology Bradykinin - pharmacology Capsaicin - pharmacology Cardiac Volume - physiology Coronary Circulation - drug effects Coronary Circulation - physiology Dogs Female Heart Failure - physiopathology Kidney - innervation Male Neurons, Afferent - physiology Oxygen Consumption - physiology Plasma Substitutes - pharmacology Plasma Volume - physiology Reflex - drug effects Reflex - physiology Sympathetic Nervous System - cytology Sympathetic Nervous System - physiology Ventricular Pressure - drug effects Ventricular Pressure - physiology |
| title | Volume expansion potentiates cardiac sympathetic afferent reflex in dogs |
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