A Transcriptional Regulator of a Pristinamycin Resistance Gene in Streptomyces coelicolor

Pip is apristinamycin-induced transcriptional regulatorprotein detected in many Streptomyces species by its ability to specifically bind sequence motifs within the promoter of a Streptomyces pristinaespiralis multidrug resistance gene (ptr). To investigate the possible role of Pip in regulating mult...

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Veröffentlicht in:	The Journal of biological chemistry 2001-01, Vol.276 (2), p.1479-1485
Hauptverfasser:	Folcher, Marc, Morris, Rowan P., Dale, Glenn, Salah-Bey-Hocini, Khadidja, Viollier, Patrick H., Thompson, Charles J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Bacterial Proteins Base Sequence Drug Resistance, Microbial - genetics Drug Resistance, Multiple - genetics Gene Expression Regulation, Bacterial Membrane Proteins - genetics Molecular Sequence Data pep gene Peptide Synthases - genetics Pip protein Pristinamycin Promoter Regions, Genetic ptr gene Repressor Proteins - genetics Sequence Alignment Sequence Homology, Nucleic Acid streptogramin B Streptomyces - drug effects Streptomyces - genetics Streptomyces coelicolor Synercid TetR protein Transcription, Genetic virginiamycin Virginiamycin - pharmacology
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