Cannabinoid CB receptor activation decreases cerebral infarction in a mouse focal ischemia reperfusion model

Cannabinoid CB(2) Receptor (CB(2)) activation has been shown to have immunomodulatory properties without psychotropic effects. The hypothesis of this study is that selective CB(2) agonist treatment can attenuate cerebral ischemia/reperfusion injury. Selective CB(2) agonists (O-3853, O-1966) were adm...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2007-07, Vol.27 (7), p.1387-1396
Hauptverfasser:	Zhang, Ming, Martin, Billy R, Adler, Martin W, Razdan, Raj K, Jallo, Jack I, Tuma, Ronald F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - blood supply Brain - metabolism Brain - physiopathology Cell Adhesion - immunology Cerebral Infarction - immunology Cerebral Infarction - metabolism Cerebral Infarction - physiopathology Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Leukocyte Rolling - immunology Male Mice Mice, Inbred C57BL Neuroprotective Agents - pharmacology Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - metabolism Reperfusion Injury - immunology Reperfusion Injury - metabolism Reperfusion Injury - physiopathology
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