Activation of antigen-specific T cells by artificial cell constructs having immobilized multimeric peptide–class I complexes and recombinant B7–Fc proteins

T cell activation results from the engagement of multiple receptors on T cells by their respective ligands on antigen presenting cells. Studies using artificial cell surface constructs have demonstrated that effective T cell response requires that antigen be presented on a solid surface with dimensi...

Ausführliche Beschreibung